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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 39 for “"Camptothecin"”.
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Total synthesis of ḏḻ-camptothecin.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 1975
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Genetic Diversity and Camptothecin Variation in Camptotheca Decaisne
… source of the promising anti-cancer alkaloids camptothecins. The main objectives of this study are (1) to reveal the genetic diversity of Camptotheca and to identify taxa with RAPD markers; (2) to determine the camptothecin (CPT) variations within and among different populations and taxa, with …
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Effects of several abiotic and biotic factors and plant hormones on growth, morophology, and camptothecin accumulation in Camptotheca acuminata seedlings
… on growth, morphology, and secondary metabolite, camptothecin (CPT, an anti-cancer compound) accumulation in Camptotheca acuminata. Five experiments were conducted with C. acuminata seedlings in a hydroponic system with commercial media and fluorescent lights and at 22-26 °C to investigate the …
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Messa a punto di procedure per la semi-sintesi di composti ad attività antitumorale partendo da prodotti naturali. Studi di struttura-attività
Camptothecin, (CPT) is a pentacyclic alkaloid isolated for the first time from the Chinese tree Camptotheca acuminata, and which has soon attracted the attention of medicinal chemists and pharmacologists due to its promising anti-cancer activity against the most aggressive histo-types. So far, most …
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Using a chemical genetics approach to dissect the nitrogen signalling pathway in Arabidopsis
… The screen identified a plant-derived alkaloid, camptothecin, that enhanced pNRT2.1::LUC expression under N-repressive conditions. The positive effect of camptothecin on expression of the endogenous NRT2.1 gene was confirmed using real-time PCR and shown to extend to other N-repressed genes of …
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Development of novel antibody-targeted nanoparticle strategies for treatment of pancreatic cancer
… drugs was attempted including gemcitabine and camptothecin, and an experimental FLIP inhibitor 3642. Given its hydrophilic nature, a derivative of the double emulsion method was employed to entrap gemcitabine. But, while this showed in vitro efficacy, concerns regarding entrapment and ligand …
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The Role of Multi-Drug Resistance Associated Protein 4 and P-glycoprotein in Resistance of Neuroblastoma to Topotecan and Irinotecan
… modalities are under development. The camptothecin analogs topotecan and irinotecan have been identified as successful cytotoxic agents. For topotecan, pharmacokinetically guided dosing to achieve a systemic exposure associated with preclinical anti-tumor activity in neuroblastoma …
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Development of versatile drug delivery strategies using PLGA nanoparticles
… Anti DR5 mAbs conjugated NP loaded with camptothecin demonstrated significant cell toxicity; a result of synergistic efficacy between camptothecin delivery and DR5 triggered apoptosis.<br/><br/>In a third study, PLGA NP were conjugated with sialic acid di(a,2^ 8) N- Acetyl-neuraminic acid …
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Studies on Type I and Type II DNA Topoisomerases From Mammalian Mitochondria
… supercoiled DNA is directly inhibited by camptothecin and indirectly by m- AMSA, a DNA intercalator. The relaxation of positively supercoiled DNA is also inhibited by camptothecin, however, with 10 to 20 fold less efficiency. Like all DNA topoisomerases, the mitochondrial enzyme forms a …
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Characterizing the Role of the E3 Ubiquitin Ligase Subunit MAEA in DNA Repair and Replication
… Cas9 screens using the chemotherapeutic agents camptothecin and etoposide. My subsequent investigations demonstrate that MAEA loss leads to a severe homologous recombination (HR) impairment as exemplified by multiple genotoxic hypersensitivities. This HR deficiency is not the result of an …
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DESIGN, SYNTHESIS, AND BIOLOGICAL EVALUATION OF NOVEL INDENOISOQUINOLINES AS POTENTIAL ANTICANCER AGENTS
… in the treatment of solid tumors, their common camptothecin-based structure is plagued by physicochemical and pharmacological issues. For these reasons, alternative structures with Top1 inhibitory activity are currently needed. The objectives of this research were to: (1) establish new and …
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Exploiting alkaloid biosynthesis in Madagascar periwinkle to obtain natural product derivatives and new biocatalysts
… monoterpene indole alkaloid biosynthesis, and camptothecin derivatives from Ophiorrhiza pumila quinoline alkaloid biosynthesis, are anticancer agents currently used in the clinic. Strictosidine synthase is a key enzyme in the biosynthesis of these medicinal natural products, but its narrow …
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Maleinimid-funktionalisierte wasserlösliche Derivate klinisch etablierter Zytostatika – albuminbindende Prodrugs für eine verbesserte Chemotherapie
… Diese Verbindungen ließen sich mit Derivaten von Camptothecin (CPT), Bendamustin und einem maßgeschneiderten Platin-Liganden zu albuminbindenden CPT-, Bendamustin- und Carboplatin-Derivaten umsetzen. <br>Albuminbindende Prodrugs des Zytostatikums CPT zeigen eine gegenüber CPT bis zu 27fach …
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Factors Influencing Topotecan CNS Penetration in Mouse Models
Camptothecin analogs such as topotecan are currently tested in clinical trials for brain tumors. However the clinical outcome is far below the expectations, which are derived from the promising preclinical studies. This discrepancy could be partially attributed to the presence of two barrier …
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Roles of H2A.z in Fission Yeast Chromatin
… to UV. Deletion strain of h2A.z is sensitive to Camptothecin. Histones H3 and H4 are obtained in Msc1 and H2A.z purifications and we’ve shown that histone H4 from these purifications has low level of Lysine 16 acetylation (H4 K16 Ac). Deletion strains of h2A.z, swr1 and msc1 are shown to be …
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Saccharomyces cerevisiae DNA helicases Mph1, Srs2 and Sgs1 collaborate for the reinitiation of stalled or collapsed replication forks
… die DNA angreifen, wie MMS, 4-NQO und besonders Camptothecin ist höher als diejenige vergleichbarer Einzelmutanten von mph1 und srs2. Überexpression von SGS1 kann die Sensitivität dieser Mutanten gegenüber Schädigung der DNA teilweise unterdrücken.Zwei Modelle werden vorgestellt, die von einem …
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Synthesis and Characterization of Redox-Sensitive Polymer and Prodrug for Targeted Drug Delivery
… nanoparticles. SN-38 (7-ethyl-10-hydroxy-camptothecin), a potent metabolite of irinotecan (CPT-11), has been extensively investigated in the past for direct usage in order to fully exploit its cytotoxic potency. Here, 2,4-dinitrobenzene sulfonyl (DNS) moiety was conjugated to SN-38 to …
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Untersuchungen zur Rolle des <i>MPH1</i>-Gens aus <i>Saccharomyces cerevisiae</i> bei der Reinitiation der Replikation nach schadensinduzierten Arresten
… Raten wie auch die durch die Mutagene 4-NQO und Camptothecin induzierten Frequenzen auftretender Rekombinationsereignisse in mph1-, rad30-, rev3-, sgs1- und srs2-Mutanten sowie der entsprechenden Doppelmutanten mit mph1 ermittelt. Zusätzlich wurden die durch 4-NQO induzierten Mutationsfrequenzen …
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