Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 31 for “"CYP450"”.
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The significance of OATP and CYP450 in statin-flavonoid interactions
… and the possible significance of OATP transport, CYP450 metabolism and mevalonate synthesis” reviews what is currently know about how flavonoids may interact with statin hepatic transport and metabolism, identifies what flavonoids are inhibitors of these pathways, how this compares to known …
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Stereoselective metabolism of verapamil and four other chiral drugs by cDNA expressed CYP450's.
… and four other chiral drugs by cDNA expressed CYP450's.
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Investigating the chemical space and metabolic bioactivation of natural products and cross-reactivity of chemical inhibitors in CYP450 phenotyping
Natural products have been exploited by humans as the most consistently reliable source of medicines for hundreds of years. Owing to the great diversity in chemical scaffolds they encompass, these compounds provide an almost limitless starting point for the discovery and development of novel …
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COMPUTATIONAL ENZYME ENGINEERING: FROM MOLECULAR MODELING TO MACHINE LEARNING
… this work is the prediction of cytochrome P450 (CYP450)-mediated metabolism and inhibition, which play critical roles in drug efficacy and toxicity. A systematic benchmarking study of machine learning models for CYP450 substrate and inhibitor prediction was conducted, followed by the development …
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Paracetamol metabolism in postoperative patients
… medicines to indicate the activity of their CYP450 enzymes that are involved in paracetamol metabolism. Urine and blood samples were collected to determine paracetamol pharmacokinetics, CYP450 activity, inflammatory cytokine concentration and for evidence of hepatotoxicity. Results: There …
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The effects of extended-release eprinomectin on heifer performance and fescue toxicity and an evaluation of parasite resistance
… after three years of use and to explore CYP450 activity and liver function as potential mechanism for extended-release eprinomectin to mitigate fescue toxicity in fall-born beef heifers grazing endophyte-infected tall fescue. Only one extended-release anthelmintic is currently on the …
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HEPATIC DIFFERENTIATION OF HUMAN AMNIOTIC EPITHELIAL CELLS AND IN VIVO THERAPEUTIC EFFECT ON ANIMAL MODEL OF CIRRHOSIS
… REGULATION IN GENES INVOLVED IN LIVER FUNCTION, CYP450 ACTIVITIES AND LIVER TRANSCRIPTION FACTORS. IMMUNOFLUORESCENCE STAINING SHOWED POSITIVITY FOR LIVER SPECIFIC MARKERS. FUNCTIONALLY, THESE CELLS SECRETED ALBUMIN, EXHIBITED INDUCIBLE CYP2C9 AND CYP3A4 ENZYMATIC ACTIVITIES, WERE ABLE TO UPTAKE …
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The bioactive role of omega-3 endocannabinoid epoxide regioisomers
… lipoxygenase and cytochrome P450 (CYP450) to generate novel oxygenated lipid mediators. Recently, CYP450 2J2 (CYP2J2) was found to metabolize EPEA to epoxyeicosatetraenoic-ethanolamide (EEQ-EAs) and DHEA to epoxydocosapentaenoic-ethanolamide (EDP-EAs) that are known as omega-3 eCB …
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Patient Characteristics and Outcomes of Gastrointestinal Stromal Tumor Patients Undergoing Imatinib Plasma Level Testing
… older, or were being treated concomitantly with CYP450 substrate drugs. As expected, CYP450 inducers correlated with a lower plasma imatinib levels in GIST patients. Renal metabolism of imatinib accounts for <10%, so it was not included in the analysis but may affect covariates. Interestingly, …
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Translational high-dimesional drug interaction discovery and validation using health record databases and pharmacokinetics models
… for quantifying fraction of metabolism (fm) of CYP450 isozymes for FDA approved drugs. A reproducible data collection protocol was developed to extract key information from publicly available in vitro selective CYP enzyme inhibition studies. The fm was then estimated from the curated data. Then, …
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Micro and Nano patterns for Biosensing: from enzymatic assays to single cells interaction arrays
… this methodology has been extended to CYP450 enzymes like CYP3A4, one of the main targets for the phase I drug metabolism via a droplet microreactors arrays containing CYP3A4 enzyme mixed with model inhibitors (erythromycin) and enzymatic chemiluminescent substrates …
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Toward improved in vitro models for human health risk assessment : mechanisms of short-chain per- and polyfluoroalkyl substances (PFAS) toxicity.
… of short-chain PFAS on human cytochrome P450 (CYP450) enzymes; and (5) evaluate the influence of short-chain PFAS on gene expression profiles relevant to toxicity using a liver-on-a-chip model. The findings of this research have the potential to impact decision-making processes related to PFAS, …
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Characterization of the Hepatotoxicity of Rifampicin and Isoniazid
… of <em>hPXR </em>mice (7) rifampicin may induce CYP450 changes associated with increased hydrazine reactivity with cellular proteins, (8) multiple [2Fe-2S]-containing proteins and (9) [Fe-S] assembly machinery proteins may be down-regulated in mice due to isoniazid. Together these data …
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Fluctuations and Instantons in Complex Landscapes: From Ligand Unbinding to Proton Transfer
… application of AIMD, are the cytochromes P450 (CYP450s). Most AIMD calculations are performed using plane-wave (PW) density functional theory as an electronic structure method; conversely, computational enzymology is generally performed using calculations with Gaussian basis sets. In this …
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Safety Assessment and Chemical Fingerprint Analysis of Medicinal Plants Commonly Consumed As Herbal Teas; Rooibos (<em>Aspalathus Linearis</em>) and Moringa (<em>Moringa Oleifera</em>)
… of rooibos tea to alter the activity of CYP450 isozymes. In chapter two, the phytochemical investigation of <em>A. linearis</em> resulted in the isolation and characterization of 14 phenolic compounds. Safety assessment of the phytochemicals through interaction with CYP, PXR, and P gp was …
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Metabolism and gene expression during diapause in athropods
… diapause entry in A. socius. Reptin, TFDp2, CYP450, AKR are significantly upregulated in pre-diapause embryos, and ACLY and Capthesin B-like protease are downregulated compared to non-diapause embryos. The need for genes upregulated in pre-diapause embryos appears to be transient as these …
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Human Genetics, Psychotropic Drugs, and Acts of Violence
… is discussed. Genetic testing of certain CYP450s could be helpful in preventing the emergence of acts of violence. Genotyping is a powerful tool in determining metabolic rates, but there are complicating issues, e.g., substrate specificity, enzyme promiscuity, unreliability of the probe …
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Καπνιστικές συνήθειες γονέων παιδιών με συγγενείς καρδιοπάθειες στην περιγεννητική περίοδο
… με γενετικούς πολυμορφισμούς των CYP450 και MTHFD1 να τροποποιούν την επίδραση του καπνίσματος. Τέλος, τα αποτελέσματα από αναλύσεις Mendelian randomisation δεν υποστήριξαν ισχυρή αιτιώδη σχέση. Συμπεράσματα: Η παρούσα συστηματική ανασκόπηση υποστηρίζει ότι η έκθεση στον καπνό του …
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Quantitative pharmacoproteomics investigation of anti-cancer drugs in mouse. Development and optimisation of proteomics workflows for evaluating the effect of anti-cancer drugs on mouse liver
… metabolites by drug metabolizing enzymes (e.g. CYP450 enzymes) that cause cellular, tissue or organ damage. Pharmacoproteomics is beginning to take a central role in studying changes in protein expression corresponding to drug administration, the results of which, inform about the mode of …
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Potamanautes warreni biomarker assays to monitor silver nanomaterial contaminants in aquatic environments
… mortality and biomarkers of oxidative stress (CYP450, SOD, CAT, GST) evaluated in crab tissues. The overall results demonstrated that: (1) AgNPs may be transformed in both size and state under variable environmental conditions. The formation of smaller aggregates at higher temperatures suggests …
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