Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 116 for “"CREB"”.
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CREB transcription factors and long-term memory in Drosophila
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1995.
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The Role of CREB in Social Isolation and Natural Reward Behavior
The role of CREB (cyclic AMP Response Element Binding protein) has been known to play a role in complex behaviors such as learning and memory, drug reward and depression. The work presented in this dissertation examines the role of CREB in an inactive stress paradigm, social isolation. Social …
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An investigation of the role of CreB deubiquitinating enzyme in the regulation of carbon metabolism in Aspergillus nidulans
… mediated by the deubiquitinating enzyme CreB, are involved in the regulatory pathway in A. nidulans. However, the molecular mechanisms are still unknown. Previously, partial loss-of-function alleles of creA and creB indicated genetic interaction, and this was extended to analysis of …
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Non-canonical Activation of CREB/crh-1 Mediates Neuroprotection in a <i>Caenorhabditis elegans</i> Model of Excitotoxic Necrosis
… the activation of the transcription factor CREB by its phosphorylation, but on its own this mode of CREB activation is promiscuous. We aim to elucidate the specific mechanism of CREB activation in excitotoxicity-induced neuroprotection, focusing on three suggested models: CREB …
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Untersuchungen zur Funktion von cAMP Response Element Binding Protein (CREB) und Activating Transcription Factor 1 (ATF1) während der Embryonalentwicklung der Maus
… cAMP Response Element Binding Protein (CREB), cAMP Response Modulatory Protein (CREM) und Activating Transcription Factor 1 (ATF1) werden innerhalb der Leucinzipperproteine in der CREB/ATF-Unterfamilie zusammengefaßt. Verschiedene Hormone, Wachstumsfaktoren und Neurotransmitter …
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Phosphorylation of Glucocorticoid Receptor tau1c Transactivation Domain Enhances Binding to CREB Binding Protein (CBP) TAZ2 and a Microfluidic, High Throughput Protein Crystal Growth Method for Microgravity
… cysteine rich fragment (CH3) of the co-activator CREB binding protein (CBP). Because CH3 overlaps the CBP transcriptional adaptor zinc binding (TAZ) 2 domain, implicated in phosphorylation dependent binding to other unstructured transcription factor domains, we investigated if GR interacts with …
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An Investigation of the Role of Insulin Deficiency and Loss of PI3K-Akt Signaling Downstream Regulators GSK3β -CREB Signaling in the Pathogenesis of the Diabetic Brain
… impaired insulin-mediated phosphorylation of CREB/GSK3β, critical neuronal signals downstream of PI3K-Akt pathway and direct support of these proteins will prevent these neurodegenerative changes. A transgenic murine model with downregulation of CREB in the forebrain was used to complement …
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Distribution of proteins involved in carbon catabolite repression in Aspergillus nidulans.
… of proteins involved in CCR including CreA, CreB, CreC and CreD in A. nidulans in repressing and derepressing conditions. The major regulatory protein involved in CCR in A. nidulans is CreA. It is a DNA-binding repressor, but very little is known about the molecular events that allow CreA …
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Interferon-gamma suppresses melanogenesis in B16 melanoma cells and primary human melanocytes
… by IFN-γ occured through the disturbance of CREB binding ability on MITF promoter by reducing the binding of CBP and CREB. These results suggest that IFN-γ decreases melanogenesis through inhibiting the binding of CBP and CREB and block the MITF and tyrosinase expression. Inflammatory …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… of cAMP response element-binding protein (CREB). Downstream targets of CREB activation in neuroendocrine differentiation as well as in neoangiogenesis are largely unknown, indicating that the underlying mechanisms of β-adrenergic signaling in prostate cancer progression are far from …
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Photo Control of Protein Activity Using Genetically Encoded Photoswitches
… negative inhibitor to the transcription factor CREB (opto-DN-CREB). opto-DN-CREB was designed by fusing a transcription factor inhibitor (A-CREB) to PYP and making complementary mutations to PYP using the software suite ROSETTA. We demonstrate that opto-DN-CREB binds selectively to CREB in the …
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Signaltransduktion im Gehirn SIV-infizierter Rhesusaffen
… Konzentration des cAMP und die Expression des CREB Proteins erwiesen sich als geeignete Untersuchungsparameter. cAMP dient unter anderem dem Neurotransmitter Dopamin in der postsynaptischen Zelle als sogenannter „second messenger“. CREB ist in der darauffolgenden Transduktionskaskade ein …
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The Role of MicroRNA-378a-5p and its Target Genes in Differentiation and Fusion of BeWo Cells
… assays, we showed that miR-378a-5p targets CREB. Transfection of miR-378a-5p decreased, while antimiR-378a-5p increased CREB protein and mRNA levels. We found that a miR-378a-5p target gene, Nodal, induced STB differentiation by activating CREB. Nodal is downregulated by miR-378a-5p but …
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Molecular mechanisms responsible for the dynamic modulation of macrophage responses to varying dosages of lipopolysaccharide
… activity of the transcription factors FoxO1 and CREB, respectively. Super-low-dose LPS mildly activated FoxO1 and pro-inflammatory gene transcription without inducing anti-inflammatory genes or activating CREB, and this pro-inflammatory skewing could be abolished by inhibition of GSK3 or direct …
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Cγ- and Cα-Subunits Provide the Specificity for cAMP/PKA Function
… and Cα migrated to the nucleus, phosphorylated CREB (cAMP responsive element binding protein) and increased the levels of immunoreactive CREB. Phosphorylated CREB in the nuclear extracts of Cγ and Cα clones bound to a CRE element in super gel mobility shift assay. Surprisingly, Cα, but not Cγ …
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Identification and Targeting of Downstream Ar-Camkk2-Mediated Mechanisms For The Treatment of Advanced Prostate Cancer
… cyclic-AMP response element-binding protein (CREB). Cancer cell-intrinsic CAMKK2 signaling promoted CRPC in part through increasing the activity of CREB. Molecularly, this was shown to occur through the calcium/calmodulin-dependent protein kinase I-mediated phosphorylation of CREB on its …
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Role of an Adenylyl Cyclase Isoform in Alcohol's Effect on Cyclic AMP Regulated Gene Expression in Mammalian Cells
… cyclic AMP (cAMP) signaling pathway including CREB-CRE regulated expression of various genes is implicated in the predisposition to and development of alcoholism in humans. Alcohol also induces changes in inflammatory and immune responses; these changes increase the incidence of pneumonias and …
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The Novel Role of Interleukin-1 Receptor-Associated Kinase 1 in the Signaling Process Controlling Innate Immunity and Inflammation
… in the activation of transcription factors CREB and ATF-1 by stimulating CREB-Ser133 and ATF-1 phosphorylation. CREB transcription factor family induces genes involved in cellular metabolism, gene transcription, cell cycle regulation, cell survival, as well as growth factor and cytokine …
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Investigation of the Role of Histone Acetylation in Hippocampus-Dependent Memory Formation
… proteins. Mutating the histone acetyltransferase CREB-binding protein (CBP) impairs long-term memory formation, and pharmacologically blocking histone deacetylases (HDAC) enhances long-term memory formation. Memory enhancement by HDAC inhibitors requires the interaction between the transcription …
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Role of Dopamine D3 receptor in the regulation of memory related genes
… of signaling molecules MAPKs, Akt and CREB to assess whether their phosphorylation levels were affected by PA in wild-type (WT) and D3-/- mice hippocampi. Increased phosphorylation levels of CREB and ERK were detected in D3-/- mice performing PA task, while Akt activation was observed …
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