Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 23 for “"COL1A1"”.
-
Role of Prostaglandin E2 In The Regulation of Pancreatic Stellate Cells Hyper Activity Associated With Pancreatic Cancer
… at the molecular level, with a focus on COL1A1. Collagen I deposition by PSC is one of the most important events in pancreatic cancer. I found that PGE2 regulates PSC through activation of COL1A1 expression and transcriptional activity. Downstream of PGE2, silencing of EP4 receptor caused …
-
The role of DNA methylation in transcriptional regulation of the human type 1 alpha 2 collagen (COL1A2) gene
… it consists of a heterotrimer of two alpha 1 (COL1A1) and one alpha 2 (COL1A2) chains. Reduced collagen gene expression is almost always correlated with pathological conditions and cellular transformation. Numerous studies have suggested that methylation of the cytosines in CpG dinucleotides is …
-
Μελέτη συχνότητας γενετικών πολυμορφισμών της παθοφυσιολογικής οδού του κολλαγόνου στην γήρανση του δέρματος
… με το μονοπάτι του κολλαγόνου, των rs1800012 του COL1A1, rs12722 του COL5A1 και rs1799750 του MMP1, στον ελληνικό και ευρωπαϊκό πληθυσμό, με στόχο την αξιολόγηση του τρόπου με τον οποίο ο γονότυπος μπορεί να συμβάλει στη διαμόρφωση εξατομικευμένων προσεγγίσεων πρόληψης και φροντίδας του δέρματος. …
-
Genetic risk factors for anterior cruciate ligament ruptures
… individuals to ACL ruptures. Candidate genes (COL1A1, COL5A1 and COL12A1) were selected based on the biological function of their encoded proteins (type I, type V and type XII collagen respectively) within the basic structural and functional unit of ligaments, namely the collagen microfibril.
-
Whole exome sequencing: a customised approach to exploring the genetic basis of musculoskeletal soft tissue injuries
… 11) and the α1 chain of type I collagen (COL1A1, chromosome 17) were previously associated with the risk of injury and were therefore prioritised for further interrogation. Variants within these regions, which had either been previously associated with injury risk or prioritised from the …
-
Synovial Fibrosis in Osteoarthritis of the Knee: Mechanism of Development and Potential Therapeutic Targets
… cAMP levels and reduced TGF-β 1-stimulated COL1A1, a-SMA, and TIMP-1 expression in OA synoviocytes. Forskolin treatment increased HA secretion and PRG4 expression and production. Moreover, HA and PRG4 reduced a-SMA expression and content, and PRG4 reduced COL1A1 expression and procollagen I …
-
Genetic risk factors for overuse and acute musculoskeletal injuries
… the association several collagen gene (COL1A1, COL5A1, COL6A1, COL11A1, COL11A2 and COL12A1) variants with chronic lower limb tendinopathies, such as Achilles tendinopathy, and other exercise-associated phenotypes involving the musculoskeletal system. These genes encode for important …
-
Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… the presence of translational changes in Col1a1, Col1a2, and Spp1 highlighted effects of SMN deficiency on translational regulation, in the absence of transcriptional alterations. Validation studies in both mice and SMA patient-derived fibroblasts further underscored the potential of …
-
Whole exome sequencing: a customised approach to exploring the genetic basis of musculoskeletal soft tissue injuries
… 11q22) and the α1 chain of type I collagen (COL1A1, 17q21.33), have previously been associated with the risk of injury and were therefore prioritised for further interrogation. Previously associated variants within these regions and/or new candidate variants identified by whole exome …
-
Biochemical Analysis of Evolutionary Divergent Vertebrate Larp6 Proteins
… binding activity of all LARP6 proteins for the COL1A1 stem loop RNA from the appropriate species was measured by electrophoretic mobility shift assays (EMSAs).
-
Modulation of microRNA Functions by the 3’ Untranslated Regions of CD44 and Tumour Suppressor Candidate 2
… the CD44 3’UTR, downstream target mRNAs, CDC42, Col1a1 and FN1 had an increased expression along with CD44. When the 3’UTR of TUSC2 was over-expressed, there was an increased translation of TUSC2 and the downstream targets, tissue inhibitor of metalloproteinases (TIMP) -2 and -3.The 3’UTRs of …
-
Snail1-mediated Gene Repression Links EMT to Enhanced Biliary Epithelial Cell Survival and Lung Epithelial Cancer Cell Migration
… TGF-β1 transiently increased Collagen 1 alpha 1(Col1A1) production in 603B cells. Up-regulation of Snail1 following TGF-1 stimulation was required for EMT-associated changes in 603B cells. Interestingly, Snail1 induction was dispensable for TGF-β1 to enhance Col1A1 expression, arguing against the …
-
Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… inhibitor array) and gene expression of COL1A1, COL3A1, MMP1, MMP2, TIMP1 and PPAR-γ mRNA (qPCR). Cells from the stromal vascular fraction (SVF) were cultured and characterised by immunocytochemistry and compared to human preadipocytes sourced commercially. The secretion of FGF, …
-
Anti-inflammatory and joint-protective effects of blueberries in a monosodium iodoacetate (MIA) induced rat model of osteoarthritis
… samples. The gene expression of MMP3 and Col1a1 were significantly upregulated in the MIA group compared to the control group. A non-significant decrease was observed with blueberry treatment in MMP2, MMP3, Sufl 1 and NFĸB expression. These results suggest that whole blueberries with its …
-
Novel Network-Based Models for High-dimensional Data
… novel breast cancer risk genes, including ADCY4, COL1A1, and FGF4, and resulted in improved prediction accuracy, offering new oppor tunities for early diagnosis and personalized treatment strategies in oncology. In addition to cancer genomics, we extended this approach to survival analysis for …
-
Overcoming wound healing complications following radiotherapy in human breast dermal fibroblasts, through the influence of preadipocytes from the stromal vascular fraction
… inhibitor array) and gene expression of COL1A1, COL3A1, MMP1, MMP2, TIMP1 and PPAR-γ mRNA (qPCR). Cells from the stromal vascular fraction (SVF) were cultured and characterised by immunocytochemistry and compared to human preadipocytes sourced commercially. The secretion of FGF, …
-
Studies on Genomic G-Quadruplexes
… formation are investigated, including the COL1A1 osteoporosis gene. A number of quadruplex sequences are found to be conserved between human and mice, in similar positions. This is investigated further, and used to provide further evidence that there is some significance to these sequences. …
-
Investigating the role of a FAM111B mutation in hereditary fibrosing poikiloderma (POIKTMP) using induced pluripotent stem cell (iPSC) model
… RNA expression of pro-fibrotic markers (COL1A1; COL3A1; α-SMA) was similar between patient and control iPSC-MSCs. Collagen staining and quantification also showed no statistical differences between patient and control cells. These results suggest that FAM111B does not directly alter the …
-
Skeletal muscle weakness and mitochondrial dysfunction in the osteogenesis imperfecta murine (oim) model
… of mutations in the type I collagen genes, COL1A1 and COL1A2, approximately 85 % of the time with the remaining 15 % of cases arising from mutations in genes involved in posttranslational modification of type I collagen, osteoblast maturation or mineralization. OI is a heterogeneous disorder …
-
Extracellular-matrix mediated regulation of human uterine leiomyoma smooth muscle cells and potential targeting by the anti-fibrotic drug halofuginone
… (5) transcripts of COL13A1 and TGFβ1, but not COL1A1, TGFβ3, DMT and LOX3, were altered by EOD HF treatment at 0.5 mg/kg body weight. These findings not only further validate the use of the UL-xenografted mouse model as an excellent model system to explore the mechanisms involved in the …
Page 1 of 2