Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 707 for “"CD8"”.
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Mitochondrial regulation of CD8+ T cell cytotoxicity
… killing activity of differentiated, cytotoxic CD8+ T cells (CTLs) remains unanswered. In this work I analyse CTLs derived from USP30-deficient mice, which have been previously characterised as part of the Infection, Immunity and Immunophenotype Consortium and shown to display altered CTL …
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Hedgehog signalling in CD8+ T cell memory
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CD8⁺ T Cell Response to Influenza Virus
… step in clearing the infection. Antigen specific CD8+ T lymphocytes are selected and activated in the mediastinal lymph node, proliferate and gain effector function, then migrate to the lungs, where they selectively destroy infected cells. The CD8+ effector population pool undergoes a phase of …
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The regulation of CD8+ T cells by nutrient availability
… was to explore how nutrient availability control CD8+ T lymphocytes. The focus was the regulation and function of autophagy as CD8 T cells encounter amino acid deprived conditions. The study also examined the role of the AMP dependent kinase in CD8+ T cell responses to metabolic stress. To study …
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Cytokine signaling control of naïve CD8⁺ T-cell homeostasis
… a wide diversity of target specificity. Naive CD8⁺ T-cells depend on T-Cell Receptor (TCR) and ye cytokine signals for their homeostatic survival and proliferation, but differences in sensitivity to these homeostatic signals among T-cell clones have been generally attributed to differences in …
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Supramolecular Peptide Nanofiber Vaccines for Eliciting CD8+ T-cell Responses
CD8+ T cells play a central role in immunity against intracellular pathogens and cancer.Vaccines that elicit robust CD8+ T cell responses are desirable for protection against such infectious diseases and cancers. Subunit vaccines using whole protein or peptide epitopes are becoming increasingly …
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Characterization of CD8 T cell responses in Mycobacterium Tuberculosis infection
… and magnitude of CFP10 and ESAT6-specific CD8 T cell responses in individuals with latent Mycobacterium tuberculosis (MTB) infection (LTBI) and active TB disease, and further define MTB-specific CD8 T cell phenotypes associated with latent infection and active disease. Ex vivo IFN? Elispots …
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Streptococcus pneumoniae mediated negative regulation of CD8+ T cell effector function
… pathogen can modulate the ongoing adaptive CD8+ T cell response to IAV.
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Modulation of CD8+ T Cell Function by Beta2-Adrenergic Receptor Signaling
… work has demonstrated that various subsets of CD8+ T cells have differential expression of the ADRB2 transcript. The role of ADRB2 signaling on the differentiation and acute effector functions of CD8+ T cells remains poorly understood. More importantly, its effect on CD8+ T cell memory …
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Constraints on the CD8 T cell response in chronic HBV infection
… by a large influx of non-virus specific CD8 T cells, which we hypothesize could provide insights into mechanisms of failure of viral control and liver damage in this setting. We compared the effector function of total circulating and intrahepatic CD8 T cells in CHB patients and healthy …
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Continuous expression of TOX safeguards exhausted CD8 T cell epigenetic fate
CD8 T cell exhaustion is a major barrier limiting anti-tumor therapy. Though checkpoint blockade temporarily improves exhausted CD8 T cell (Tex) function, the underlying epigenetic landscape of Tex remains largely unchanged, preventing their durable “reinvigoration.” Whereas the transcription …
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In vitro generation and programming of human CD8+ memory T cells
… generation of persistent and functional memory CD8+ T cells. The integration of a multitude of signals during naïve cell activation plays an important role in the programming of CD8+ T cells responses. However, knowledge of the regulation of naïve cell programming in humans is limited. …
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Immunization with synthetic nanoparticles to generate mucosal CD8 T Cell responses
… vaccine to stimulate mucosal and systemic CD8 immunity. We first assessed the ability of ICMVs to elicit mucosal CD8 response, against the model antigen ovalbumin (OVA), by administration of the nanoparticles through the lungs. We explored the use of 2 different Toll-like receptor agonists …
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A Microfluidics-Based Approach For Isolation of Antigen-Specific Cd8+ T Cells
… <p> Immunotherapies that leverage tumor-specific CD8<sup>+ </sup>cytotoxic T cells have shown great promise for the treatment of NSCLC. However, although highly promising, the success of these therapies has largely been hampered by the challenge of isolating tumor-specific CD8<sup>+</sup> T cells …
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The Role of TCR Engagement Strength in Antitumor CD8 T Cell Exhaustion
… part by the persistence of progenitor exhausted CD8 T cells (Tpex). Tpex serve as a source for the pool of effector T cells that tend to have a short lifespan or eventually become dysfunctional in uncleared tumors. In contrast to the short-lived feature of their daughter cells, Tpex are able to …
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