Global ETD Search
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Showing 1 to 17 of 17 for “"CD39"”.
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Novel Modulators of CD39 and CD73
CD39 and CD73 are crucial in purinergic signalling, converting triphosphate and diphosphate nucleotides such as ATP and ADP into AMP, which CD73 further degrades into adenosine. CD39 and CD73 dysregulation is linked to various diseases. In cancer, their upregulation is associated with immune …
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Tumour infiltrating T cells in non-small cell lung cancer and their interactions with cancer-associated fibroblasts
… (CTL) response in other solid tumours. Recently, CD39 has emerged as a marker to identify tumour relevant T cells and CD39 expression on CTL is correlated with T cell exhaustion. CD39+CD8+T cells often co-express the tissue resident memory marker CD103 and display an exhausted tissue resident …
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Immunotolerance regeneration by T regulatory cells in autologous haematopoietic stem cell transplantation for multiple sclerosis
… Tregs expressing the ectonucleotidase enzyme CD39 exert immunoregulatory function by suppressing T helper (Th)17-related immune responses, which has been significantly associated with MS pathogenesis. However, this immunoregulatory function was reported to be decreased in MS patients. CD39 …
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Purinergic angiogenesis : an investigation of the role of extracellular nucleotide mediated signaling in angiogenesis
… into anti-angiogenesis based cancer therapies. CD39/NTPDasel is an ectoenzyme expressed by vascular endothelium that hydrolyses extracellular nucleoside di- and triphosphates to the monophosphate derivatives. As such, this enzyme has a role in modulating endothelial responses to mucleotides that …
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Targeting the adenosine pathway reshapes a myeloid-dependent tumour microenvironment in pancreatic ductal adenocarcinoma. An opportunity for therapeutic intervention
… of a molecule of ATP by enzymes called CD39 and CD73. The stimulation of the adenosine receptors by extracellular adenosine on the immune cells has been shown to favour a pro-tumorigenic and tolerogenic microenvironment. Results: Using syngeneic, *in vivo* murine models of PDAC with …
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ADP regulation of insulin secretion and beta-cell apoptosis
… rat aortic VSMCs revealed the expression of CD39, CD39L1 and CD73. 48 hours treatment of high glucose significantly decreased CD39 gene expression and increased CD39L1 expression. Bioluminescence assays also revealed that high glucose caused VSMCs released of ATP and the ectonucleotidase …
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Molecular epidemiology of haemoglobin in the population of Libya and the molecular biology of normal and abnormal globin gene expression
… β-thalassaemia mutations found in Libya were βo CD39 (C -> T) N = 14, β+ IVS-I,6 (T -> C) N = 8 and β+ IVS-I, 110 (G -> A) N = 6 and these mutations accounted for more than 90% of all β-thalassaemia alleles studied. The two rare mutations found were ~o IVS-I,I(G ->A) N = 1 and IVS-I,-1 (CD30) (G …
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The Expression Of Connexin-43 By CD11c+ Dendritic Cells Is Required to Maintain CD4+ Foxp3+ Regulatory T Cell Population in Peripheral Lymphoid Organs
… these cells, demonstrated by lower expression of CD39 and higher expression of CD73, ectonucleotidases mediating T<sub>R</sub> cell immunosuppressive function. We propose that the presence of Cx43 on the surface of dendritic cells is required for effective communication between T<sub>R</sub> cells …
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Regulation of blood platelet function by the AGC family of protein kinases
… (PGI₂ ); and (3) the ectonucleotidase CD39. NO and PGI2 stimulate signalling cascades that result in the activation of the AGC family of Ser/Thr protein kinases (PKA, PKG and PKC). Once activated these kinase blunt platelet function through the phosphorylation of signalling proteins …
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Gestörte Expression von CD70 und CD86 auf naiven CD27-B-Lymphozyten von Patienten mit Variablem Immundefektsyndrom (CVID)
… von Oberflächenmarkern der Aktivierung (CD39, CD69), Differenzierung (CD24, CD27, CD38) oder der T- B- Zellwechselwirkung (CD25, CD70, CD86) aufwiesen. Wir stimulierten durch Zellsortierung gereinigte naive B- Zellen (CD19+CD27-IgM+IgDhighIgG-IgA-) von 10 CVID- Patienten und 10 gesunden …
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… exhaustion markers such as PD-1, TIM-3 and CD39. Notably, Single-cell RNA sequencing of HIV-specific CD8⁺ T cells identified a distinct BCL6^high PD1⁻ progenitor population that gives rise to two distinct subsets via divergent differentiation trajectories: one branch generates effector-like …
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Efeitos de crises crônicas e agudas induzidas por pentilenotetrazol sobre a hidrólise de nucleotídeos púricos em soro de ratos adultos
… ATP envolvendo as enzimas ATP difosfoidrolase (CD39) e 5’-nucleotidase (CD73). Embora esta associação enzimática já esteja bem descrita, o envolvimento da enzima fosfodiesterase não pode ser descartado, uma vez que esta hidrolisa nucleotídeos como ATP e ADP, além de outros substratos. …
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Activation of T regulatory cells in Type II Immune Responses
… activation and suppression-related molecules (CD39, Class II MHC, and PD-1) within each subpopulation. We further examined for changes in B cell subsets. We found RT had lower lymphocyte counts, Treg, and B cells compared to HV. RT had fewer Treg subpopulations expressing CXCR3 or CCR6, and a …
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Pre-operative ablative radiotherapy in combination with immunotherapy and novel agents in pancreatic cancer
… following radiotherapy and the expression of CD39 and CD73, key ectoenzymes involved in the conversion of ATP to immunosuppressive adenosine, was increased on Tregs and myeloid cells respectively. However, combining ablative radiotherapy with dual PD-L1 and CTLA-4 blockade or CD73 inhibition …
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The immunomodulatory properties of Vitamin D in vitro and in vivo
… by 1,25(OH)2D3 may be partially due to a CD39-dependent mechanism. <br/>In vivo evidence for a positive association between serum 25(OH)D and Foxp3+Treg numbers was further investigated in vitro. High concentrations of 1,25(OH)2D3 (10-6M) increased the frequency of Foxp3+ T cells in …
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DISSECTING IMMUNE DYSREGULATION IN PATIENTS WITHTHYMIC EPITHELIAL TUMORS BY AUTOANTIBODY ANDSINGLE-CELL PROFILING
… inhibitory receptors such as PD1, TIM3, CD38 and CD39, supporting the investigation of PD1 and TIM3 blockade as strategies to reinvigorate resident effectors. Paired scTCR analyses revealed clonal bridges between tumor and blood in all groups. In AB, B1 and B2 thymoma patients, shared clones were …
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Promoting Conceptual Development through Mediation: An Investigation of Gal’perin’s Concept-Based Instruction of Genre in Chinese EFL Writing Classrooms
In sociocultural research on second language (L2) learning, there has been a growing interest in concretising Vygotskian principles in the language classroom. Gal’perin’s model for Concept-Based Instruction (CBI) has been seen as a promising framework that unifies the theoretical principles and …