Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 35 for “"CD133"”.
-
The role of CD133 in mouse incisor tooth epithelium
Since its discovery, CD133 has been used to identify, isolate and characterise many different stem cell types across a wide variety of tissues. Nonetheless, to date not much has been elucidated about its function in these cells. The continuously growing mouse incisor contains a large population of …
-
EXAMINATION OF CD133 AND CD147 AS CANCER STEM CELL MARKERS
… thus paramount. The cell surface glycoproteins CD133 and CD147 were examined as potential markers of cancer stem cells found in glioblastoma. Here we found evidence which shows that formation of neurospheres with U87MG glioblastoma cells may be driven by increased expression of CD147, correlated …
-
Biology of adult human normal and leukaemia CD133+ stem cells
Recently, CD133 has been used extensively as a marker for identification of stem cells from human normal and malignant tissues. Human normal CD 133+ stem cells are capable of multilineage in vitro and in vivo differentiation providing a novel source of stem cells for regenerative therapy, whereas, …
-
Involvement of CD133+ stem cells in the chemoresistance of glioma
… multipotency. The novel cell-membrane protein CD133 has been identified as a marker of stem-like cells in glioma. Interestingly, the CDI 33+ population of GBM has been found to be selectively resistant to radiation and chemotherapy relative to the CD133- bulk tumour mass, revealing a potential …
-
Regenerationspotenzial CD133+-hämatopoetischer Progenitorzellen der humanen Nabelschnur beim Nierendefekt im Mausmodell
… ein Reservoir an Progenitorzellen des Phänotyps CD133 in der humanen Niere. Mehrere Forschungsgruppen arbeiteten ebenfalls mit murinen Transplantationsmodellen, doch bisher gibt es kaum Publikationen zur Transplantation - von mittels MACS hoch aufgereinigten - humanen Stammzellen in murine …
-
CD133 Antibody Conjugation to Decellularized Human Heart Valves For Circulating Endothelial Progenitor Cell Capture
… aim of this study is to examine the capacity of CD133 antibody-conjugated valve tissue to capture circulating endothelial progenitor cells (EPCs). Decellularized human pulmonary valve tissue was conjugated with CD133 antibody at varying concentrations and exposed to CD133 expressing NTERA-2 cl.D1 …
-
Signaling pathways regulating self-renewal, differentiation, and multipotency of CD133+ umbilical cord blood stem cells
… lab adapted a culture technique to grow immature CD133+ UCBSCs (CD133+ cells). Although CD133+ cells proliferate rapidly in culture, a minority self-renew and remain CD133+, while a majority differentiate and become CD133-. Therefore, new strategies to identify and grow immature UCBSCs are …
-
Investigation of Cancer Stem Cells (CSCs)-derived exosomes and their influence on the tumor microenvironment
… and CD81, LCSC-derived exosomes are enriched in CD133 protein. Immunoprecipitation (IP) experiments revealed that by immunoprecipitating the culture SN of CD133 expressing cells with an antibody against CD133 protein, typical exosomal markers, such as Tsg101 and Rab5b, are contained in the …
-
Expression profile of multidrug resistance genes and proteins in cancerous and stem cells
… may be the major obstacle in treating gliomas. CD133 and nestin have been suggested as the markers of CSCs and natural stem cells. The primary focus of this study was to identify CD133+/nestin+ stem-like cells and discover their association with multidrug resistance (MDR) related genes, i.e. …
-
The Role of Glutamine and Mevalonate Pathway In Affecting The Stemness and Viability of Glioblastoma Stem Cells
… neurospheres, express the neural stem marker CD133, and are highly tumorigenic. On the other hand, in the presence of fetal bovine serum (FBS), the glioblastoma stem cells undergo differentiation.</p> <p>In this study we used glioblastoma stem cells, GSC11 and GSC23, previously isolated from …
-
The role of stem cells and WNT signalling pathway in renal cell carcinoma
… carcinoma using immunohistochemical markers (CD133 and CD105). To review the WNT signalling pathway in renal cell carcinomas using selected protein expression by immunohistochemistry (β-Catenin).Materials and methods: Ten-year retrospective study in which sixty-four cases of renal cell …
-
Haematopoietic progenitor cells in carotid disease
… HPC numbers were measured by flow cytometry (CD133+ve/CD34+ve) and early colony forming unit assay (eCFU). HPC function was measured by migration assay and by staining for senescence associated B-galactosidase (SA-Bgal). HPC number and function was then measured in 62 patients undergoing CEA …
-
Stemness status in differentiated and undifferentiated glioma cells
… The three stem cell-related protein (CD133, Oct4-A and BMP3) expressions were investigated in control, hypoxic and serum-deprived U87-MG cells in order to shed light on the influence the micro-environment has in generating stem cells. Hypoxia offered a rapid state of undifferentiation …
-
Connecting brain tumor stem cells with their primary tumor and exploring glycogen synthase kinase -3ß regulation of cell fate
… and differentiation, preferentially in the CD133-expressing tumor-initiating fraction. In addition, GSC frequency was significantly reduced. Our data suggest that targeting GSK3 presents a viable treatment strategy in eradicating self-renewing GSCs.
-
Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… was found to be expressed at low levels in CD133+/ α2β1hi stem cell fraction and upregulated in CD133-= α2β1lo differentiated prostate cancer cells. In summary, the results in this thesis demonstrate the complexity and tumour type specificity of ALDH expression. This creates challenges for …
-
Towards the development of fluorescent probes targeting aldehyde dehydrogenase (ALDH) in cancer. Expression and epigenetic modulation of ALDH1A1, ALDH2 and ALDH3A1 in selected in vitro models.
… was found to be expressed at low levels in CD133+/ α2β1hi stem cell fraction and upregulated in CD133-= α2β1lo differentiated prostate cancer cells. In summary, the results in this thesis demonstrate the complexity and tumour type specificity of ALDH expression. This creates challenges for …
-
Novel Regulation of the Cell Cycle During Cell Fate Decisions in the Central Nervous System
… that Spy1 is an important driver of the CD133+ brain tumour initiating cell (BTIC) population. Spy1 controls the ability of BTICs to symmetrically divide and the amplification of the SPDYA gene loci correlates with poor patient prognosis. We show that Spy1 is expressed at high levels in …
-
The Development of Novel Radioimmunoconjugates for the PET Imaging and Radioimmunotherapy of Cancer
… are dedicated to discussing the development of a CD133- targeting monoclonal antibody — [<sup>89</sup>Zr]Zr-DFO-aCD133 — majorly focusing on immunoPET imaging of small cell lung cancer in traditional and advanced tumor murine models. We have recently begun to explore the therapeutic efficacy of …
-
pH Regulatory Molecules In The Tumour Microenvironment: Modulators Of Aggressiveness And Immune Profile Of Human Hepatocellular Carcinoma
… markers (<i>CD13, CD24, CD44, CD90, EpCAM, CD133, KRT19, OCT4, NANOG</i> and <i>SOX2</i>). Selected HCC, non-tumour and normal liver tissue samples were evaluated by immunohistochemistry (IHC) to detect the presence and localization of CAIX, CAXII and VATPase and to assess the distribution …
-
Synovial sarcoma : translating gene expression into patient care
… sarcoma cells, typified by expression of CD133, which exhibit stem-like properties and are relatively resistant to doxorubicin but susceptible to 17-AAG at clinically relevant concentrations.
Page 1 of 2