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Showing 1 to 20 of 61 for “"C. difficile"”.
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Isolation and Characterization of Anti-SLP Single Domain Antibodies for the Therapy of C. difficile Infection
Clostridium difficile is the leading cause of death from gastrointestinal infections in Canada. Current antiobiotic treatment is non-ideal due to the high incidence of relapse and the rise in hyper-virulent antibiotic-resistant strains. Surface layer proteins (SLPs) cover the entire bacterial …
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Prevalence and control of Clostridium difficile in patients with cystic fibrosis
… investigate the high prevalence of Clostridium difficile in patients with cystic fibrosis (CF), and to control its dissemination. To determine the carriage rate of C. difficile in CF patients, 60 patients were tested for C. difficile and its toxin. In total, 50% of patients were found to be …
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Regulation of to xin Synthesis By Clostridium Difficile
<p><em>Clostridium difficile</em> is the leading definable cause of nosocomial diarrhea worldwide due to its virulence, multi-drug resistance, spore-forming ability, and environmental persistence. The incidence of <em>C. difficile</em> infection (CDI) has been increasing exponentially in the last …
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Mechanistic Insights Into Vancomycin Resistance In Clostridioides Difficile
<p><em>C. difficile </em>is a nosocomial, opportunistic pathogen that has become more hypervirulent over the last decade. Vancomycin is currently a frontline antibiotic for the treatment of <em>C. difficile</em> infections. Yet, strains of <em>C. difficile</em> are becoming non-susceptible to …
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Proteomics as a tool for the characterisation of nosocomial pathogens
… two major nosocomial pathogens, S. aureus and C. difficile and to further investigate the intraspecies diversity of C. difficile using a genotypic approach. The surface-associated proteins of S. aureus and intracellular stable ribosomal proteins of C. difficile were analysed by MALDI-TOF-MS and …
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Hypervirulent Clostridium Difficile Strains: Adherence, Toxin Production and Sporulation
<p><italic>Clostridium difficile</italic> is a leading cause of nosocomial infections, and recently emerged "hypervirulent" <italic> C. difficile </italic>strains have caused epidemics worldwide. We hypothesized that multiple factors were responsible for this phenotype, particularly the interaction …
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Estudio descriptivo de la microbiota intestinal en pacientes con infección por Clostridium difficile y en individuos colonizados por Clostridium difficile.
Clostridium difficile es un bacilo Gram positivo, anaerobio estricto y formador de esporas. Constituye la principal causa de diarrea nosocomial en pacientes hospitalizados. Su patogenicidad se asocia al uso de antibióticos y a una respuesta inmune disminuida, así como a la edad avanzada, …
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Charakterisierung der zellulären Bindung und Aufnahme von clostridialen Toxinen
C. difficile ist der Auslöser der Antibiotika-assoziierten Diarrhoe und der pseudomembranösen Colitis. Die beiden Hauptvirulenzfaktoren des Keims sind Toxin A und Toxin B. Beides sind Mitglieder der Familie der großen clostridialen Zytotoxine, zu denen noch das a-Toxin von C. novyi sowie das …
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Towards Phage Therapy: Characterization of Clostridioides difficile Bacteriophages from a South African Strain Collection
Clostridioides difficile infection is a worldwide public health concern that affects persons with gastrointestinal dysbiosis, notably hospitalised patients on antibiotic therapy and those with other types of gastrointestinal conditions. This opportunistic infection is caused by a Grampositive, …
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Characterization of Metronidazole- and Vancomycin-Resistant Clinical Isolates of Clostridium Difficile
… Clinical Isolates of <em>Clostridium difficile</em></strong></p> <p>Chioma Odo, MS.</p> <p>Supervisory Professor: Charles Darkoh, Ph.D.</p> <p><strong>ABSTRACT</strong></p> <p>The incidence of <em>C. difficile</em> infections (CDI) has been increasing at an alarming rate. This was …
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Régulation du c-di-GMP et rôle de ce messager secondaire dans la formation de pili de type IV chez Clostridium difficile.
… à c-di-GMP dans une bactérie donnée. Clostridium difficile est une bactérie pathogène causant des diarrhées nosocomiales, des colites et pouvant causer des décès chez l’Homme. Les phénotypes impliqués dans la pathogenèse de C. difficile et leur régulation demeurent en grande partie méconnus. Le …
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The eco-evolutionary dynamics of microbial populations
… exceedingly difficult. For instance, Clostridium difficile became widely known for being the world's leading cause of hospital associated diarrhea, but people can also have C. difficile in their gut without developing diarrhea. Although these asymptomatic carriers are now thought to be the largest …
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Clostridium difficile: expression of virulence factors, resistance to disinfectants and interactions with human cells
Clostridium difficile is the most common cause of nosocomial diarrhoea today. Through the changing epidemiology of C. difficile infection, the emergence and decline of different strains of varying virulence and a broad spectrum of disease from asymptomatic carriage and mild infection to severe …
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Gnotobiotic Pig Models for the Study of Enteric Pathogen Replication and Pathogenesis
Clostridioides difficile (C. difficile) and human rotavirus (HRV) are leading causes of bacterial and viral gastroenteritis worldwide. Treatment and vaccination options for both pathogens have significant limitations. C. difficile infections are treated with antibiotics, which is paradoxical as C. …
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Investigating the enzyme activity of a <i>Clostridioides difficile</i> amidase complex
<i>Clostridioides difficile</i> is a highly antibiotic resistant and infectious endospore-forming bacterium, responsible for an estimated 450,000 cases per year. The formation of an endospore is necessary for the survival of the bacterium while in-transit between hosts and while passing through the …
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Identification and characterization of a receptor for Clostridium Difficile enterotoxin
Clostridium difficile and its toxins are implicated as the cause of pseudomembranous colitis in patients undergoing antibiotic therapy. Very little information is known about how these toxins bind to cells and cause disease. In an attempt to understand how these toxins work this dissertation …
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Investigating novel treatment approaches to combat Clostridioides difficile
… treatment approaches to combat Clostridioides difficile Rusha Pal ABSTRACT Clostridioides difficile is the leading cause of antibiotic-induced diarrhea and colitis in hospitals and communities worldwide. The enteric pathogen, classified to be an "urgent threat" by the United States Center for …
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Die Rolle der Stuhldiagnostik bei Patienten mit nosokomialer Diarrhoe
… auf enteropathogene Bakterien (ohne C. difficile) hat eine niedrige <br>Ausbeute an positiven Resultaten, die bei zunehmender Hospitalisationsdauer von <br>initial 3.3 (innerhalb der ersten 72 Stunden) auf 0 (nach mehr als 31 Tagen) <br>abnimmt. Die Untersuchungen auf das Toxin von C. …
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Colonisation with pathogenic drug-resistant bacteria and Clostridioides difficile among residents of residential care facilities in Cape Town, South Africa
… to determine the prevalence of MDROs and C. difficile and risk factors for carriage amongst residents of RCFs in Cape Town, South Africa. Methods We performed a cross-sectional surveillance study at three RCFs. Chromogenic agar was used to screen skin swabs for methicillin-resistant …
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