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Showing 1 to 20 of 62 for “"BrCa"”.
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PARP-estäjät BRCA-positiivisen rintasyövän hoidossa
… Helmi Susanna Karjaluoto Työn nimi: PARP-estäjät BRCA-positiivisen rintasyövän hoidossa Työn laji: Kandidaatintutkielma Kuukausi ja vuosi: huhtikuu 2026 Sivumäärä: 20 Avainsanat: rintasyöpä, BRCA-mutaatio, PARP, PARP-estäjät, talatsoparibi, olaparibi Ohjaaja: Yliopistolehtori Tuuli Karhu, …
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Predictors of Contralateral Breast Cancer In Brca Negative Women
… (HBOC) is caused by mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes. Women carrying a mutation in these genes are at an increased risk to develop a second breast cancer. Contralateral breast cancer is the most common second primary cancer in patients treated for a first breast …
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Η επίδραση της φορείας BRCA στην κύηση και τη γονιμότητα
Τα γονίδια BRCA1 και BRCA2 αποτελούν δύο γονίδια που παίζουν σπουδαίο ρόλο στην επιδιόρθωση μεταλλάξεων της διπλής αλυσίδας του DNA. Μεταλλάξεις σε αυτά τα γονίδια σχετίζονται με την εμφάνιση κακοηθειών με σημαντικότερες τον καρκίνο του μαστού και των ωοθηκών. Οι φορείς των μεταλλάξεων αυτών …
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Knowledge, Attitudes, and Utilization of Brca Testing Among Obstetricians and Gynecologists
… that is associated with mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes. Carriers of <em>BRCA</em> mutations, both men and women, are at an increased risk for developing certain cancers. Carriers are most notably at an increased risk to develop breast and ovarian cancers; however an …
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An Examination of Dimensions of Perceived Behavioral Control Regarding Genetic Counseling and Testing for BRCA 1 and BRCA 2 in African-American Women at Moderate to High-Risk for Breast Cancer
… in genetic counseling and testing for BRCA 1/2. The goals of this mixed methods study were twofold; first, to explore levels of perceived behavioral control and general motivations regarding genetic counseling and testing for BRCA 1/2 in African-American women at moderate to high-risk …
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Combination Chemotherapy and In vivo Modeling of BRCA-deficient, High-grade Serous Ovarian Cancer
… over half of ovarian cancer cases exhibit BRCA-deficiency by either germ line or somatic mutation, or epigenetic silencing. The importance of BRCA-deficiency is highlighted in its association with increased platinum sensitivity. Novel therapeutics such as PARP inhibitors have also been …
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Accuracy of The Brcapro Risk Assessment Model In Males Presenting to Md Anderson For Brca Testing
<p>ACCURACY OF THE BRCAPRO RISK ASSESSMENT MODEL IN MALES PRESENTING TO MD ANDERSON FOR<em> BRCA</em> TESTING</p> <p>Publication No. _______</p> <p>Carolyn A. Garby, B.S.</p> <p>Supervisory Professor: Banu Arun, M.D.</p> <p>Hereditary Breast and Ovarian Cancer (HBOC) syndrome is due to mutations in …
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The Role of Ifitm3 In The Immune Response of Brca-Deficient High Grade Serous Ovarian Carcinoma
… Prior studies showed that BRCA-deficient high grade serous ovarian carcinoma (HGSOC) had increased tumor infiltrating lymphocytes (TILs) compared to BRCA-wildtype (WT). To better understand the underlying immune mechanism in these tumors, a preliminary transcriptome analysis …
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I Cut Off My... Voice: An Autoethnography of an Artist and Art Educator with a BRCA Genetic Mutation
<p>The effects of BRCA genetic mutations on artists and art educators had not been known. Autoethnography is a qualitative method for writing about personal experiences through a cultural lens. I used my personal experiences within a BRCA positive community to understand shared experiences among …
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Cancer Cell Antiviral Signaling Amplifies Transcription Output Through Chromatin Alterations To Drive Therapy Resistance
… are transferred from stromal to breast cancer (BrCa) cells and activate retinoic-acid inducible gene I (RIG-I) and signal transducer and activator of transcription 1 (STAT1) dependent antiviral signaling in BrCa cells. In parallel, stromal cells activate Notch receptor 3 (NOTCH3) on BrCa cells …
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Breast Cancer and Cortisol Secretion in Relation to the Per3 Vntr, Chronotype, and Sleep
… and increased premenopausal breast cancer (BrCA) risk. Methods: Two studies were conducted. One study based in India identified histologically confirmed BrCA cases that were frequency-matched on age (+ 5 years), geographic region, menopausal status, and time of interview (+ 3 months) to …
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MCP-1, Macrophages and Tumorigenesis in the C3(1)/Sv40Tag Mouse Model of Breast Cancer: Benefits of Quercetin
<p>Breast cancer (BrCa) is the second most commonly diagnosed cancer and the leading cause of cancer related death in women in the United States. A substantial proportion of breast cancers are incited, aggravated or caused by lifestyle factors. For example, consumption of high fat diets (HFD), as …
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Cancer Incidence In First and Second Degree Relatives of Brca1 and Brca2 Mutation Carriers
<p>Mutations in the <em>BRCA1</em> or <em>BRCA2</em> genes are associated with increased risks for breast, ovarian, and several other cancers. The purpose of this study was to evaluate the incidence of cancers in first and second degree relatives of <em>BRCA</em> mutation carriers compared to the …
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Tracking Treatment Response and Resistance to Parp Inhibition (Talazoparib) In Hereditary Pancreatic Cancer.
… (HR). In tumors with HR defects (i.e. <em>BRCA</em> mutants), there is a shift to error-prone DNA repair and subsequent genomic instability and cell death.</p> <p>In 2014, Olaparib became the first FDA-approved PARP inhibitor for the treatment of <em>BRCA</em>-mutant ovarian cancer. In the …
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Factors Influencing Uptake of Risk-Reducing Salpingo-Oophorectomy By Brca1 and Brca2 Mutation Carriers
<p>Germline mutations in the <em>BRCA1</em> and <em>BRCA2</em> genes are associated with significantly increased risks for ovarian cancer. The National Comprehensive Cancer Network (NCCN) currently recommends that female BRCA mutation carriers undergo risk-reducing salpingo-oophorectomy (RRSO) …
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NF-YA ISOFORMS ROLES IN CLAUDIN LOW CANCERS
… tumors of epithelial origin, among which BRCA and STAD. In human breast and gastric cancers and cell lines, NF-YAs isoform is highly expressed in all subtypes except in Claudinlow in which NF-YAl isoform is predominant. Recently it has been identified a 158 genes signature defining …
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Assessing risk of familial breast cancer: effectiveness of current UK guidelines
… (3-8%) and high risk (>8%). Those with a BRCA mutation are considered to be very high risk. Women at moderate or high risk are offered screening from age 40. This study aimed to assess the effectiveness of NICE risk categorisation at identifying women at risk of early onset breast …
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Sviperfðabreytingar í Eggjastokkakrabbameinum
… en meðal gena sem stuðla að viðgerðinni eru BRCA1 og 2. Vanvirknin getur stafað af ýmsum orsökum svo sem BRCA-stökkbreytingu í kímlínu, áunni (e. Sporadic) stökkbreytingu og hypermetýleringu á stýrisvæði BRCA1. Æxlisfrumur sem tapað hafa umræddum viðgerðarferli eru taldar viðkvæmari fyrir …
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