Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Biomembranes"”.
-
Light-induced transformations in biomembranes
Cellular membranes constantly experience remodeling, as exemplified by morphological changes during endo- and exocytosis. Regulation of membrane morphology is essential for these processes. In this work, we attempt to establish a regulation path based on the use of photoswitches exhibiting …
-
Physical biology of biomembranes and biomolecules (PHYBIOM)
To study mechanical properties of red blood cells, the combination of an AC dielectrophoretic apparatus and a single-beam optical tweezers were used. The experiments were performed with high frequency (e.g. 10 MHz) below the second turnover point between positive and negative dielectrophoresis. The …
-
Solid-State NMR Studies of Polymeric and Biomembranes
The objective of this dissertation is to demonstrate different applications of ssNMR, with particular emphasis on uses in polymeric and biosciences. First, dynamics investigations on two polymers will be discussed: (1) disulfonated poly(arylene ether sulfone)s /poly(ethylene glycol) blends …
-
Adaptive Spline-based Finite Element Method with Application to Phase-field Models of Biomembranes
<p>Interfaces play a dominant role in governing the response of many biological systems and they pose many challenges to traditional finite element. For sharp-interface model, traditional finite element methods necessitate the finite element mesh to align with surfaces of discontinuities. …
-
Structure and Dynamics of Biomembranes containing Cholesterol and other Biologically-Important Sterols : a computational perspective
In this thesis, the differential effects of three closely-related sterols: ergosterol, cholesterol and lanosterol on the structural and dynamical properties of a model dipalmitoyl phosphatidylcholine (DPPC) membrane were examined using Molecular Dynamics (MD) simulations and Neutron Scattering (NS) …
-
Blood coagulation reactions on nanoscale membrane surfaces
… of regulatory and catalytic subunits. The biomembranes involved in these reactions not only provide a platform for these procoagulant proteins, but can also affect their function. Increased exposure of acidic phospholipids on the outer leaflet of the plasma membrane can dramatically …
-
Shaping of membranes by arc-like particles
This dissertation analyzes the interaction of biomembranes with arc-like particles, which gives rise to complex morphologies of organelles inside cells. The shaping of membranes is investigated with coarse-grained modeling and Monte Carlo simulations. In the coarse-grained model, the membrane is …
-
Amelioration of oxidative lung injury by antiarrhythmic agents
… are effective antioxidants and can protect biomembranes against lipid peroxidation injury and post-ischemic reperfusion injury of the lung. We have investigated the mechanism(s) of action of these drugs in ameliorating oxidative tissue injury and found that these drugs are not only effective …
-
Turning stealth liposomes into cationic liposomes for anticancer drug delivery
… negatively charged model liposomes mimicking biomembranes at lowered pH was substantiated by 3-4 times increase in average sizes of the mixture of the convertible liposomes and the model liposomes at pH 6.0 compared to pH 7.4. The doxorubicin-loaded convertible liposomes show increased …
-
Biophysical Studies of Cholesterol in Unsaturated Phospholipid Model Membranes
… PUFA-driven alteration of the architecture of biomembranes, a mechanism through which human health may be impacted.</p>
-
Effects of taurine and hypotaurine on oxidative lung injury
… were also ineffective (p > 0.05) in protecting biomembranes against free radical-induced lipid peroxidation. However, taurine (10-300 mM) and hypotaurine (2-30 mM) were found to possess the ability to scavenge hydroxyl radicals. Taurine (148 and 193 mM) and hypotaurine (19 mM) were found to …
-
Age-Associated Expression Patterns of OATP 1B1 and OATP 1B3 and Their Effect on the Disposition of Fexofenadine
… mechanisms to transport them across the biomembranes of the drug removal organs. OATP1B1 and OATP1B3 are transporters on the sinusoidal membrane of the liver which work in concert with the drug metabolizing enzymes as part of the drug removal process. It is known that the development of …
-
Solution and solid-state NMR studies of amphotericin B
Since its discovery in 1955, amphotericin B (AmB) has been a vital clinical agent. It remains the drug of last resort for systemic fungal infections despite its significant toxicity. Despite over 50 years of clinical use, very few cases of AmB resistance have been reported. This lack of resistance …
-
Spatial correlation of lipid phase fluctuations in model membranes studied with two-photon fluorescence microscopy
The temporal dynamics of lipid phase fluctuations and the spatial organization of model lipid membranes was studied using Two-photon excitation fluorescence microscopy. Lipid membranes of different composition were reconstituted in Giant Unilamellar Vesicles (GUVs) and labeled with the environment …
-
ΑΛΛΗΛΕΠΙΔΡΑΣΕΙΣ ΙΟΝΤΩΝ ΚΑΙ ΠΡΟΣΑΝΑΤΟΛΙΣΜΕΝΩΝ ΘΥΛΑΚΟΕΙΔΩΝ ΚΥΑΝΟΒΑΚΤΗΡΙΩΝ
THE REGULATION OF PHOTOELECTRON TRANSPORT ACTIVITY BY INORGANIC IONS WAS STUDIED WITH PERMEABLE ANACYSTIS NIDULANS CELLS, CONTAINING SEALED AND PROPERLY ORIENTED THYLAKOIDS, CAPABLE OF COUPLED ELECTRON TRANSPORT TO POST-PHOTOSYSTEM I, ELECTRON ACCEPTORS. THE IONIC CONTROL OF PHOTOELECTRON TRANSPORT …