Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"Bioinformatics analysis"”.
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Bioinformatics analysis of epigenetic variants associated with melanoma
… sequence data sets have been generated, allowing analysis of genome-wide activity in cohorts of different individuals to be increasingly available. Finding associations between epigenetic variation and phenotype is one of the biggest challenges in biomedical research. Laboratories lacking …
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A Bioinformatics Analysis of Bacterial Type-III Secretion System Genes and Proteins
… Proteins conserved amongst T3SSS can be used for analysis of these systems using computational homology searching. By using tools including BLAST and HMMER in conjunction phylogenetic analysis this thesis examines the range of T3SSs, both in terms of the proteins they contain, and also the …
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Domain-based Bioinformatics Analysis and Molecular Insights for the Autoregulatory Mechanism of Phafin2
… and Phafin2- like proteins. Using different bioinformatics tools and resources, it was concluded that the polyD motif only evolved in Phafin2 and PH- or both PH-FYVE-containing proteins of animals, highlighting the association in cellular functions that might have evolved uniquely in animals. …
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Bioinformatics Analysis and Annotation of Microtubule Binding and Associated Proteins (MAPs) - Creating a Database of MAPs
… of each MT system. This research involved the analysis and annotation of four MAPs – Ensconsin in Humans, Hook (homolog 3) in Humans, Protein Regulator of Cytokinesis 1 (PRC1) in Humans and Anaphase Spindle Elongation protein (ASE1) in yeast. A bioinformatics approach was used for the …
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Bioinformatics Analysis of Whole-Exome Sequencing Data for the Identification of Nuclear and Chloroplast Diversity in Barley
… genes in Arabidopsis, for a detailed analysis of molecular diversity. My analysis showed that many contain extensive sequence variation and that patterns of single- and multiple-gene haplotypes exhibit strong geographical structuring. Furthermore, previously identified causal SNPs for …
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In-depth bioinformatics analysis of the phosphoproteome of triple negative breast cancer treated with a tumor selective NQO1 bioactivatable drug
… drug treatment. Computational and bioinformatic analysis of kinases involved through kinase substrate enrichment analysis revealed changes in downstream signaling of cell cycle checkpoint proteins. CDK1 and CDK2 substrate phosphorylation was decreased in response to combination drug therapy. …
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BIOINFORMATICS ANALYSIS OF FULL-LENGTH RNA NANOPORE SEQUENCING AT SINGLE CELL LEVEL TO STUDY TRANSCRIPTIONAL AND MUTATIONAL PATTERNS IN HUMAN LEUKEMIA
Acute myeloid leukemia (AML), an aggressive cancer originating from hematopoietic stem cells, exhibits substantial intra-tumoral heterogeneity impacting disease development, prognosis, and treatment response. However, understanding the interplay between various layers of heterogeneity at the …
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Bioinformatics analysis of liver and adipose tissue microarray data from periparturient dairy cattle and development of a web-based ruminant specific microarray database
… and proteomic levels using several bioinformatics techniques such as gene enrichment analysis or over-represented approach (ORA).The ORA analysis is widely-used in scientific community for functional analysis of high-throughput data such as microarray or RNA-sequencing. It is …
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Integrated data analytics of germline mutation classes in human cancers. An integrated bioinformatics analysis to investigate associations between germline mutation classes and human cancers.
… In summary, this project has approached the analysis of gene involvement in human primary cancers from the starting position of the mutation class that harbours the specific gene mutation. Together with their downstream resultant alterations in the associated proteins, this analysis can …
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THE ROLE OF FAM3C IN LUNG CANCER METASTASIS
… a panel of biomarkers were shortlisted based on bioinformatics analysis. Our in vitro findings on exosomal FAM3C presence in tumour cells have been verified in clinical samples. We demonstrated that cellular FAM3C induced lung cancer invasion and metastasis in vitro and in vivo. Next, we screened …
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Genomic characterization of Six1 function during skeletal muscle differentiation
… MyoD, Myf5, Myogenin and Myf6. Based on previous bioinformatics predictions, it was proposed that Six1 had a genome-wide function and cooperated with MRFs by co-regulating gene expression. A functional genomics approach (ChIP-on-Chip) was used to identify targets directly bound by Six1 in the …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… followed by next generation sequencing and bioinformatics analysis characterized Nmp4 as a negative regulator of synthetic processes and suggested the IGF1/Akt and BMP2/Smad biochemical pathways which are likely targets for Nmp4 regulation. We have experimentally verified these pathways in …
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Tumor-Cell Derived Inhibin, Beta A Is Essential For Adrenergic Effects On Fibroblast Activation
… <p><strong>Methods:</strong> Ingenuity Pathway Analysis and NetWalker were used to assess gene expression data from patients with known CESD (Center for Epidemiological Studies-Depression)-score alongside microdissected CAFs from primary ovarian cancer. Tumor samples from mice exposed to daily …
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REPSA Directed Assessment of Native Cleavage Resistance of DNA to Type IIS Restriction Endonucleases and Modification of REPSA for High Temperature Application
… parallel sequencing of the selected DNAs and bioinformatics analysis yielded a consensus binding sequence of 5'-GA(t/c)TGACC(c/a)GC(t/g)GGTCA(g/a)TC, a 20base pair palindromic site comparable to that described in the literature. Taken together, our data provide a proof-of-concept that HT-REPSA …
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Analogue enrichment of aromatic degradation through application of lignin-derived phenols
… with Illumina sequencing of labelled DNA, and bioinformatics analysis (Kaiju, Hmmer and Krona). Naturally occurring lignin-derived phenols (vanillin) are found to have influence on the phylogenetic and functional genes of the diverse bacterial population responsible for degradation of …
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The role of cellular micro-RNAs in Epstein-Barr virus induced cellular transformation and oncogenesis
… genes down-regulated by EBV. In addition, bioinformatics analysis indicated that EBV modulates the expression of multiple miRNAs predicted to target the same cellular genes.
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Insights on the Regulation of the PERIOD 2 Gene in the Cellular Response to DNA Damage
… In a separate project, we also performed bioinformatics analysis on the iron related genes to discuss the circadian regulation of iron genes in the liver. These findings shed light on the regulation of PER2 under genotoxic stress, genetic variations of Per2 in normal human population, and …
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Characterization of a Mitochondrial Localizing Molluscum Contagiosum Virus Protein: MC163R
… and produce a chemokine homolog (MC148). Bioinformatics analysis identified MC163, as another potential host-interacting protein. Further analysis of MC163 resulted in the identification of a mitochondrial localization sequence, putative superoxide dismutase (SOD)-like …
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Proteomics Study of Pre-Harvest Sprouting in Wheat
… cutting-edge technology called iTRAQ. Proteomic analysis revealed that 190 differentially expressed proteins might be involved in various cellular functions, such as carbohydrate metabolism, nitrogen metabolism, stress response, redox regulation, ATP synthesis, and protein translation, during …
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Understanding the roles for CELF2 in post-transcriptional regulation for the fate of neural stem cells.
… what transcripts are targeted by CELF2 using bioinformatics analysis. With this data, the targeted genes can be categorized into groups based on their functionality. Using this data, I aim to determine what genes and what cellular functions are most impacted by CELF2. Furthermore, as the CELF …
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