Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"Biohybrid"”.
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Low Reynolds number biohybrid swimming
Biohybrid robotics are a new class of mechanical systems which use biological cells as machine components in microscale to mesoscale actuators and motile structures. Eukaryotic cells come pre-programmed to accomplish a wide range of functionalities, from sensing environmental factors to providing …
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3D biohybrid muscle electronics systems
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Custom-Designed Biohybrid Micromotor for Potential Disease Treatment
Micromotors are recognized as promising candidates for untethered micromanipulation and targeted cargo transport. Their future application is, however, hindered by the low efficiency of drug encapsulation and their poor adaptability in physiological conditions. To address these challenges, one …
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Single molecule studies of molecular electronics and biohybrid materials
A grand challenge in materials chemistry and physics lies in understanding charge transport, chemical reactions, and polymer chain dynamics at the molecular level. In this thesis, I directly address these challenges using single molecule techniques. Recent advances in single molecule techniques …
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Enhancing the Performance of Skeletal Muscle Powered Biohybrid Robots
… jumping, swimming, and flying. The field of biohybrid robotics aims to use biological actuators, such as skeletal muscle, to power adaptable robots that respond to their environment. Previous work in this field has focused on deploying 3D skeletal muscle tissues to power robotic function. In …
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Biohybrid swimmers at low Reynolds number powered by tissue-engineered neuromuscular units
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-04-06 without embargo terms
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Biohybrid Neural Interfaces: Exploring the Role of Regional Astroglia in Neuronal Integration and Functionality
Biohybrid Neural Interfaces (BNIs) offer an innovative approach to neural implantation by incorporating living neurons and traditional neural implants. This creates a dynamic cellular environment that allows for more natural interactions with host neural tissues. Given that BNIs incorporate living …
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Biohybrid Peripheral Neural Interfaces: Combining Cell Transplantation and Flexible Electronics for Functional Neurological Restoration
… existing tissue is of paramount importance, this biohybrid strategy with the incorporation of cells may allow for a ‘controllable’ synaptic integration between implanted cells and existing circuitry. Attributes to such a biohybrid implant are: an ability to host and interact with stem-cell derived …
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Electrochemical wiring of cyanobacteria to anodes using polymers towards biohybrid devices for solar-chemical production
To accelerate the phasing out of fossil fuels, the innovation of sustainable technologies that convert solar energy to chemical energy will be crucial. Bio-photoelectrochemical devices using living microorganisms as catalysts for solar-fuel conversion could fill this gap. As a material, living …
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Photocatalysis in a New Light: A Biohybrid Approach for Improved Reactivity with Tunable, Low-Energy Light Excitation
… Chapter 2 reports the synthesis of a biohybrid photocatalyst inspired by the modular architecture of photosynthetic apparatus which conjugated a photosynthetic light harvesting protein to a transition metal photocatalyst. Spectroscopic investigation found that absorbed photoenergy was …
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A biohybrid bridge between brain and machine: Development and application of a neural implant using iPSC-derived neuronal membranes
Despite the numerous advancements in electronics interfacing with the nervous system over the decades, a long-standing challenge has been to achieve long-term stability *in vivo*. The foreign body reaction (FBR), an internal inflammatory mechanism triggered upon implantation of foreign objects, is …
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Manipulating Stiffness of Biomechanical Systems to Train Muscle
A new design for the skeleton of biohybrid robots, millimeter scale soft robots powered by engineered muscle actuators, was developed to provide a binary change in stiffness. Two variations of the design were created, one using elastic 50A resin and the other PDMS. The elastic 50A resin design was …
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ELLIE - Exteroceptive Light Locomotion in Eukaryote-Fungi
… disciplines, including the emerging field of biohybrid systems. This thesis develops and evaluates a wireless, untethered mobile robot controlled by the action potential-like activity generated by <em>Pleurotus ostreatus </em>sporocarps under red, green, and blue optical stimulation. Light is …
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Light-Harvesting, Redox Control, and Biomimicry of the Photosynthetic Antennas of Green Sulfur Bacteria
… have pioneered methods to build self-assembling biohybrid chlorosome analogs that incorporate natural pigment and synthetic polymers that mimics the natural chlorosome structure. These biohybrid constructs look and act like natural chlorosomes, although their design offers flexibility of pigment …
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DEVELOPMENT OF NANO-CELL VESICLE TECHNOLOGY SYSEM (nCVTs) FOR CANCER THERAPY
… This thesis examines the development of a nano-biohybrid system, termed nano-Cell Vesicle Technology System (nCVTs), as a drug delivery system for cancer therapy. Being a hybrid system of cell-derived and liposomal systems, nCVTs aims to harness the synergism, while overcoming the flaws of the …
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Engineering Collagen Nanostructure to Enable Stiff & Tough Cartilage Biomaterials
… collagen was then investigated as part of a biohybrid composite system where the addition of collagen vastly improved both the mechanical performance and cytocompatability of the material (Chapter 3). Finally, collagen was functinalized with alginate to enable metal-ion complexation in order …
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Tailoring the redox enzyme-material interface for enhanced electro- and photocatalytic fuel synthesis
… In addition, the resulting non-covalent biohybrids are expected to be fragile to external stimuli such as pH and salt concentration. Therefore, in this thesis, an in-depth characterisation of the enzyme-electrode interface is combined with insights into the effect of material surface …
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Single molecule studies of polymers and self-assembling materials: Effects of chain topology and entanglements
… and sol-gel transition of a new class of biohybrid functional materials comprised of synthetic pi-conjugated cores and sequence-defined oligopeptides using combined characterization tools. Over the past two decades, advances in fluorescence imaging and particle manipulation have enabled …
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Rational Engineering of Bacteria and Biohybrids for Enhanced Transport and Colonization in the Tumor Microenvironment
… for the programmed behavior of bacteria-based biohybrid systems, which will leverage the engineered bacteria to deliver therapeutics to the TME. Our work serves as the foundation for the logical and efficient design of the next generation of BBCTs.
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Halloysite for smart nano-structured materials in sustainable applications
Biohybrid nanostructured materials were prepared by the co-assembling of inorganic particles, i.e. nanoclays, with organic moieties such as biopolymers. Among clays, Halloysite Nanotubes (HNTs) were deeply investigated due to their peculiar properties: morphology, different chemistry and charges on …
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