Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Batf3"”.
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The novel roles of BCL6 and BATF3 in regulating human CD8⁺ T cell dysfunction
… landscapes. Our analyses revealed that BCL6 and BATF3 are robustly upregulated in dysfunctional CD8⁺ T cells, with ATAC-seq demonstrating enhanced chromatin accessibility at their gene loci. Transcription factor footprinting shows increased BATF3 motif occupancy in chronically stimulated cells …
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Batf3-Deficient Mice: Susceptibility to Toxoplasma gondii and Responses to IL-12 Treatment in vivo
… examined <italic>T. gondii</italic> infection of Batf3<super>-/-</super> mice, which selectively lack only lymphoid-resident CD8α<super>+</super> DCs and related peripheral CD103<super>+</super> DCs. Batf3<super>-/-</super> mice were extremely susceptible to <italic>T. gondii</italic> …
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Functional Education of Monocytes During Infection
… was controlled by systemic IL-12 produced by Batf3-dependent dendritic cells (DC) in the mucosal-associated lymphoid tissue (MALT). This work challenges the paradigm that monocyte function is dominantly imposed by local signals following tissue recruitment, and instead proposes a sequential …
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Elucidating the functional states of tumor-resident dendritic cells that drive productive anti-tumor immunity
… for a subset of dendritic cells (DC) called Batf3-driven conventional DC1, given their superior ability to initiate tumor-reactive cytotoxic CD8+ T cell responses. The exclusion or functional suppression of DC1 in tumors impedes CBT efficacy and enables tumor immune evasion and outgrowth. …
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Processing of Exogenous Hen Egg-White Lysozyme for Presentation on Major Histocompatibility Complex Class I and II Molecules
… of interferon-α/β: IFNα/β) or IFNγ signaling; Batf3-/- mice lacking CD8α+ dendritic cells: DCs) also showed reduced cross-priming. We examined the ability of draining lymph node: dLN) DCs to process and cross-present soluble HEL to CD8+ T cell hydridomas. DCs isolated from immunized, but not …
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The ontogeny and function of intestinal dendritic cells
… cDC depends on the TFs Id2, IRF8 and BatF3, the TF requirements for CD103+CD11b+ were not known. Using a mouse model that selectively depletes the TF IRF4 selectively in CD11c+ cells, we show that, similar to splenic/lymph node CD11b+ cDCs, intestinal CD103+CD11b+ cDCs depend on IRF4 …