Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"BNIP3"”.
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Investigating the Role of msBDNF – TrkB Signaling in the Maintenance of Mitochondrial Populations Through the BNIP3 Mitophagy Pathway
… Bcl-2 nineteen-kD interacting protein (BNIP3) mitophagy pathway, although the relationship is not well-defined. BNIP3 localizes to the mitochondria and triggers a loss of membrane potential leading to mitochondrial destruction. Using a murine model, functional and dysfunctional …
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IGF-1 signalling controls mitochondrial morphology and basal mitophagy in cancer
… E1B 19 kDa protein-interacting protein 3 (BNIP3) is induced by IGF-1 to support mitochondrial turnover and protection. Here, we analysed a publicly available gene expression dataset of breast cancer cells stimulated by IGF-1. Gene ontology classification revealed a signature of genes …
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Role of Pro-Apoptotic Bcl2-Homology-3 Domain (BH3)-Only Proteins in the Mutant SOD1 Mouse Model of ALS
… staining for the BH3-only proteins, Bik, Bad, BNip3, Bid, Noxa, Puma, and Hrk/Dp5, demonstrated selective staining of Hrk/Dp5, Bnip3, and Bid in astrocytes of lumbar spinal cord from end stage mutant SOD1 mice. Hrk/Dp5, Bnip3, and Bid were not observed in astrocytes of wild type mouse spinal …
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Insulin-like growth factor 1 effects on mitochondrial dynamics and mitophagy in cancer
… E1B 19 kDa Protein-Interacting Protein 3 (BNIP3). IGF-1 also activated the transcriptional regulator Nuclear Factor, Erythroid 2 Like 2 (NFE2L2/Nrf2), likely through inactivation of Glycogen Synthase 3β (GSK-3β). Both Nrf2 and Hypoxia-Inducible Factor 1α (HIF-1α) were required for …
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Neuroprotective Functions of Docosahexaenoic Acid and Epidermal Fatty Acid Binding Protein
… expression of stress response genes HIF-1α and BNIP3, increases the accumulation of reactive oxygen species, and decreases cell viability by apoptosis. Inhibition of cathepsins does not rescue neurons from PA-LTx but inhibition of necroptosis and promotion of autophagy do. DHA decreases the …
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The role of the chromatin remodeller ISWI in the cellular response to hypoxia
… target genes, increasing expression of CA9 and BNIP3, whilst reducing expression of Glut3, and leaving many others unaltered. Loss of ISWI also causes impairment in the transcription of FIH, a crucial regulator of the hypoxia response, and Rb a protein involved in cell cycle regulation. …
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Repression Of Autophagy During Erythroid Development By Gfi1b
… autophagy genes including <em>FOXO3, ATG5, BNIP3L,</em> <em>BNIP3 </em>and <em>ATG10</em>. Finally, to establish transcriptional regulation of select genes by GFI1B, I performed luciferase reporter assays on genomic elements following transient co-transfections into a non-erythroid cell …
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Effet de l’hypoxie sur la résistance des cellules cancéreuses à l’étoposide : Etude de l’apoptose et de l’autophagie
… induite par un mécanisme impliquant la protéine BNIP3. Nous avons montré que, dans les cellules HepG2, l’autophagie était induite par l’étoposide mais pas par l’hypoxie. Cependant, l’autophagie induite par l’étoposide a des conséquences différentes en fonction de la tension en oxygène puisque les …
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Transcriptional Regulation of Cardio-Pulmonary Development
… molecules that were identified in this screen. Bnip3, a hypoxia inducible, pro-apoptotic molecule that can induce mitochondrial damage, was upregulated in the dHAND-/- pharyngeal arches and heart, suggesting a role for mitochondrial damage in the observed apoptosis. I have shown that while …
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Novel Protective Agents against Cerebral Ischemia/Reperfusion Injury.
… treatment. More importantly, Nec-1 inhibited BNIP3-mediated caspase-independent cell death. Cerebral ischemia/reperfusion injury involves the activation of different pathways that lead to neuronal cell death. Given this multifactorial pathnogenesis, it is possible that a cocktail of …
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A Novel Click Chemistry-Based Method to Detect Hypoxic Tumour Cells and Characterise Their Gene Expression
… by protein expression of one of the genes (BNIP3). The expression of 10 oxidoreductases involved in the activation of hypoxia-activated anticancer prodrugs was assessed in the same fractions. In FaDu xenografts, TXNRD1 was the only oxidoreductase gene with upregulated transcription (P<0.05) …
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ROLES OF LIPOGENESIS IN BREAST CANCER PROGRESSION
… up-regulation of pro-apoptotic genes, DAPK2 and BNIP3. The activation of apoptotic pathway in the cancer stem-like cells was suppressed by FAS overexpression suggesting that resveratrol-induced apoptosis is indeed through the modulation of FAS-mediated cell survival signaling. Importantly, …
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The impact of hypoxia on out-of-field signalling responses following exposure to modulated irradiation
… hypoxia signatures such as ADM, NDRG1, and BNIP3 were observed. Although trends in the microarray analysis mimicked that predicted by TAC, the magnitude of the genetic alterations in KCNMA1, KDM1A, PNISR, RBM6, and KMT2A out-of-field could not be replicated by RT-qPCR on this occasion. …
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Hypoxia regulated pathways in urological malignancies
… together with seven primary<br/>target genes (BNIP3, CAIX, CyclinD1, GLUT1, LDH5, Oct-4 and VEGF) was assessed.<br/>Comparison was made with tumour angiogenesis (CD31), tumour stage, Fuhrman grade,<br/>maximum tumour diameter and patient survival. Further work in this thesis analysed a series …