Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 11 of 11 for “"BMP9"”.
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BMP9 Signalling in Ovarian Cancer
… work by the Inman lab identifying autocrine BMP9 as a promoter of ovarian cancer cell proliferation. The findings of Chapters 3-5 provide strong evidence indicating BMP9 as a context specific modulator of ovarian cancer cell proliferation. This significantly builds upon on the sole …
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The Role of BMP9-Induced SEMA3G in Pulmonary Vascular Stability
… also found in sporadic idiopathic PAH patients. BMP9 therapy is being investigated in PAH, as it increases *BMPR2* expression, inhibits endothelial cell permeability, and reverses vessel remodeling in PAH preclinical models. The exact mechanism by which BMP9 regulates vessel stability is unknown, …
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Bone morphogenetic proteins 9 & 10 in pulmonary arterial hypertension
… cells which maintains vascular quiescence. BMP9 and BMP10 are the high affinity ligands for this signalling complex. Administering exogenous BMP9 has been shown to reverse disease in animal models of PAH, so the Morrell group is investigating the use of BMP9 as a therapy for PAH. …
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Investigating the impact of endothelial BMPR2 loss on the proliferative response to bone morphogenetic protein 9 in pulmonary arterial hypertension
… The endothelial-selective BMPR-II ligand, BMP9, has been shown to reverse disease in animal models of PAH and suppress the proliferation of healthy endothelial cells. However, the impact of BMPR2 loss on the antiproliferative actions of BMP9 has yet to be assessed in endothelial cells from …
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Characterisation of BMP Processing and Signalling in Adipocytes
… final year, my thesis expanded to compare BMP4, BMP9, and BMP10 signalling in adipocytes. BMP4 has a well-documented function in adipocytes, whereas roles for BMP9 and BMP10 are less known. Despite BMP9 and BMP10 having almost identical signalling activities in vascular endothelial cells, my …
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Role of plasma membrane ATPase4 in the pathophysiology of pulmonary arterial hypertension
… staining and caspase-3 cleavage. In contrast, BMP9-induced Smad1/5 and TGF-β–induced Smad2 phosphorylation remained unaltered, indicating that PMCA4’s anti-apoptotic role is independent of canonical Smad signaling. A luciferase reporter construct harboring the PMCA4 3′UTR was engineered to …
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Portal hypertension in cirrhosis and its associated pulmonary vascular disorders
… those with decompensated disease. This loss of BMP9/10 suggests these ligands have a significant role in maintaining endothelial homeostasis in PH, and treatment with BMP9/10 could be a new therapeutic strategy for PH. In cirrhotic compared to control portal veins, ~3,500 genes were …
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N-linked glycosylation at position ASN98 of the ALK1 receptor protein: relevance for ALK1 function and HHT pathogenesis
… are activated by binding to the circulating BMP9 ligand. The ALK1-endoglin-BMP9 complex will then regulate endothelial proliferation by activating the SMAD pathway by phosphorylation. Mutations in the ACVRL1 gene can form a modified ALK1 protein that has a high potential to inhibit this …
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Investigation of the therapeutic potential of recombinant BMP10 in an adult mouse model of HHT1 and the crosstalk between BMP and VEGF signalling
… endoglin protein which is a coreceptor for BMP9 and BMP10. Endothelial-specific, homozygous deletion of Eng in adult mice (Eng-iKOe) has been shown to model the HHT phenotype, with the development of arteriovenous malformations (AVMs) in the pubic symphysis, associated high-output heart …
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Andstæð hlutverk TGF-ß fjölskyldunnar í fylgjumyndun og meðgöngueitrun
… Niðurstöðurnar sýndu að í næriþekjufrumum ýtti BMP9/ALK2/SMAD1/5 boðleiðin undir tjáningu ANGPTL4 sem jók frumuskrið. ANGPTL4 hafði neikvæð áhrif á viðloðun æðaþels HUVEC frumna. Í meðgöngueitrun dró úr tjáningu ANGPTL4 í fylgju miðað við í eðlilegri meðgöngu. TGF- ß/ALK5/SMAD2/3 boðleiðin ýtti …