Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"BMP2"”.
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Therapeutic Targeting Of Bmp2 In Nf1-Deficient Malignant Peripheral Nerve Sheath Tumors (mpnsts)
… gene expression profiling, our lab identified BMP2-SMAD1/5/8 signaling pathway as a therapeutic target in MPNSTs, independent of the NRAS and MEK1/2 regulation. The overall goal of my research was to validate the significance of BMP2 in MPNSTs in novel cellular models, study the combinatorial …
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Characterization of a Novel Nuclear Variant of Bmp2 and Coordinate Regulation of Col11a2 and Col27a1 by the Transcription Factor Lc-Maf
… I CHARACTERIZATION OF A NOVEL NUCLEAR VARIANT OF BMP2<br /><br />Bone morphogenetic protein 2 (Bmp2) is a signaling protein that was first detected by its ability to induce cartilage and bone formation. It has since been implicated in broad variety of developmental, patterning, and disease …
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Stimulations and modulations of chondrogenic differentiation of human embryonic stem cells
… process could be regulated by growth factors BMP2 and/or TGFI?1 in a controlled context both in vitro and in vivo. By culturing hESCs in 2-D EB monolayer and 3-D high-density micromass systems, BMP2 was shown to induce chondrogenic differentiation and maturation/hypertrophy, of which distinct …
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Identification of transcriptional mechanisms downstream of nf1 gene defeciency in malignant peripheral nerve sheath tumors
… with a focus on bone morphogenetic protein 2 (Bmp2). Experimental evidence indicated that the BMP2-SMAD1/5 pathway was activated in NF1-associated MPNST cells and inhibition of BMP2 signaling by LDN-193189 or shRNA to BMP2 decreased the motility and invasion of NF1-associated MPNST cells in …
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Signal transduction via multiple BMP receptor complexes
… of that superfamily. In the present work the BMP2 mediated signal transduction should be examined, depending on the receptor oligomerization pattern. Using kinase-deficient mutants, it could be demonstrated, that signalling via preformed BMP receptor complexes is mediated by the well …
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Defining the potential of HDAC5 and HDAC9 as therapeutic targets for Parkinson’s disease
… as being regulated by HDAC5 and HDAC9. Both BMP2 and GDF5 have been identified as promising NTFs involved in DA neuronal development and capable of protecting against α-syn-induced degeneration. Therefore, we hypothesised that mechanistically, the inhibition of HDAC5 and HDAC9 might offer …
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Advances in Bone Tissue Engineering
… were transduced with adenoviruses to express BMP2 and VEGF. An interesting interaction was discovered, where VEGF was shown to inhibit simultaneous BMP2 expression. In study IV, a periosteum-like graft was engineered, using the dermal matrix AlloDerm and seeded MSCs. When the seeded cells were …
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Topographie molekularer Faktoren der Keimzellentwicklung während der frühembryonalen Entwicklung des Kaninchens
… die Expressionsmuster der Schlüssel-Gene Blimp1, BMP2 und BMP4 untersucht und mit aus dem Mausmodell bekannten Daten verglichen. Für die Untersuchungen wurde das Kaninchen als Modellorganismus ausgewählt, weil es mit seiner flachen Keimscheibe für den Säugerembryo besonders repräsentativ ist und …
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Role of Msx homeobox genes in uterus during embryo implantation
… reported that Bone morphogenetic protein 2 (BMP2) regulates uterine stromal cell differentiation in the mouse and the human. Subsequent studies revealed that the expressions of Msx1 and Msx2 were markedly altered in response to exogenous BMP2. Functional studies performed using Msx1d/dMsx2d/d …
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BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… endoderm during pancreatic bud development. Bmp2, Bmp4, BmpR1a and BmpRII are expressed in the dorsal aorta which transiently flanks the pancreatic bud. Bmp4, Bmp7, BmpR1a, BmpR1b, and BmpRII are expressed in the pre-pancreatic mesenchyme. Interestingly, Bmp4 is expressed asymmetrically along …
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Analysis of the biochemical mechanisms of heterotopic ossification following musculoskeletal trauma
… effects the musculoskeletal injury has on BMP2-induced ectopic bone formation at the genetic level. METHODS: Prx1/Ail2/Rag and Pax7/Ail2/Rag strains of mice were used in this study. Mice received two tamoxifen injections 48 hours apart, and surgery was performed following a one-month …
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Isolierung, Charakterisierung und Funktionsanalyse von TGF-Beta-Signaltransduktionskomponenten des Fuchsbandwurms Echinococcus multilocularis
… Parasiten, EmRSK1, mit einem Zytokin des Wirts (BMP2) in vitro funktionell interagiert. Da BMP2 in Zellkultursystemen, die das Wachstum des Parasiten am befallenen Wirtsorgan nachstellen, einen deutlichen Effekt auf E. multilocularis ausübt, könnte die hier beschriebene EmRSK1/BMP2 – Interaktion …
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Nmp4 restricts bone marrow osteoprogenitors and parathyroid hormone induced bone formation in healthy and estrogen depleted female mice
… processes and suggested the IGF1/Akt and BMP2/Smad biochemical pathways which are likely targets for Nmp4 regulation. We have experimentally verified these pathways in immortalized bone marrow mesenchymal cells from wild type and Nmp4-KO mice. Disabling Nmp4 in estrogen replete or depleted …
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Characterization of skeletal stem cells derived from different musculoskeletal locations
… Prx1+ cells. Bone Morphogenetic Protein 2 (BMP2) was used to demonstrate the ability of Prx1+ cells to form bone. Our data revealed the muscle environment was not permissive for bone formation under homeostasis, while the periosteum created a supportive niche for skeletal stem cells to …
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Src Kinase Regulates TGFβ And Hyaluronan Induced Epicardial Cell Invasion, Differentiation And Migration
… migration. Tgfbr3-/- cells lack expression of BMP2 mRNA, we found that exogenous BMP2 is sufficient to drive Tgfbr3-/- (but not Tgfbr3+/+) cell migration to levels comparable to unstimulated Tgfbr3+/+ epicardial cells, without enhancing cell proliferation. We demonstrate that Src is required …
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The regulation of the hepcidin by modulators of the bone morphogenetic protein (BMP) pathway
… HepG2 and Huh7, cells abolishing the effects of BMP2 and attenuating the effects of BMP6. These effects correlated with reduced cellular pSMAD levels. Addition of recombinant BMPER peptide to primary human hepatocytes strongly downregulated hepcidin mRNA levels and abolished the effects of BMP2. …
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The roles of Rb, p107, and E2f4 in bone formation and embryonic development
… of pro-osteoblastic genes, including Bmp2, Msx2, Runx2 and Osterix. By using the same strategy to conditionally delete Rb in p107/- embryos, we observe lethality at approximately e14.5 during development.
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Bmp-Signaling Regulates A Common Transcriptional Program to Control Facial Form and Skeletal Morphogenesis
… experiment, CNC inactivation of <em>Bmp2</em>, <em>Bmp4</em>, and <em>Bmp7</em>, resulted in complete or partial loss of multiple CNC derived skeletal elements revealing a critical requirement for Bmp-signaling in membranous bone and cartilage development. Importantly, the BIG …
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Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
… blocked serum induction of Id1. Further, BMP2 is sufficient to induce Id1 expression. Given reports that SRC inhibitors can block Id1 expression, we tested the SRC inhibitor, AZD0530, and found that it inhibits the serum activation of Id1. Surprisingly, this inhibition is independent of …
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Interactions between BMP and Canonical Wnt Signaling Regulate Critical Stages of the Osteoblast Lifecycle
… of canonical Wnt signaling, synergizes with BMP2 to stimulate osteoblast differentiation and bone formation. My work was designed to conduct a full evaluation of how BMP and Wnt signals interact at discrete stages of the osteoblast lifecycle to regulate cell fate, establish a …
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