Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 350 for “"BMP"”.
-
Serum Regulation of Inhibitor of DNA Binding/Differentiation 1 Expression by a BMP Pathway and BMP Responsive El
… Id1 promoter and find that it is identical to a BMP Responsive Element (BRE). The Id1 BRE is necessary and sufficient for the serum regulation of Id1. Inhibition of the BMP pathway by siRNA depletion of Smad4, treatment with the BMP antagonist noggin, or the BMP receptor inhibitor dorsomorphin …
-
Signal transduction via multiple BMP receptor complexes
BMPs influence a variety of cellular processes. They have been shown to regulate proliferation, differentiation, migration and apoptosis and thus play central roles during developmental processes and tissue homeostasis. Ligand mediated signal transduction is transmitted via BMP type I and BMP type …
-
Expression und Isolierung des BMP-bindenden Proteins Ep45
Die BMPs (Bone morphogenetic proteins) sind Zytokine, die in fast allen Tieren exprimiert werden und zur TGF-β Superfamilie gehören. Sie spielen eine wichtige Rolle in der Knochenentwicklung, unter anderem auf Grund ihrer Fähigkeit, die Neubildung von Knochen auszulösen. Eine weitere Aufgabe der …
-
Struktur- und Funktionsanalysen an BMP Ligand-Rezeptor-Komplexen
Für BMPs wie auch die anderen Mitglieder der TGF-beta-Superfamilie beginnt der Signalweg mit der Bindung des Liganden an zwei Typen transmembranärer Rezeptoren. Die Ligand-Rezeptor Interaktionen sind dabei durch unterschiedliche Affinität und Spezifität gekennzeichnet und bilden wahrscheinlich die …
-
Characterisation of BMP Processing and Signalling in Adipocytes
… diseases. Bone morphogenic protein (BMP) 8B, part of the Transforming Growth Factor-β (TGF-β) superfamily, is key in regulating energy balance via activating brown adipose tissue (BAT) thermogenesis, presenting a potential target for obesity treatment. However, the molecular …
-
The regulation of TGFβ/BMP signalling by deubiquitylating enzymes
… including the bone morphogenetic protein (BMP), plays critical roles during embryogenesis and in adult tissue homeostasis. Hence, malfunctions in TGFß/BMP signalling result in several diseases. Signalling is initiated by ligand binding to cell surface receptor kinases, which phosphorylate …
-
Optimization of BMP Selection for Distributed Stormwater Treatment Networks
… stormwater best management practices (BMPs), necessary to meet regulatory objectives for nutrient removal and groundwater recharge. Selection of the appropriate BMPs for a particular site requires consideration of contributing drainage area characteristics, such as soil type, area, and …
-
Development of BMP type I receptor kinase inhibitors for the treatment of fibrodysplasia ossificans progressiva and the study of the BMP signaling pathway
The BMP signaling pathway is essential for embryonic development and the maintenance of tissue homeostasis. Dysregulated BMP signaling, both loss and gain-of-function, has been demonstrated in the pathogenesis of diseases including cancer, atherosclerosis, anemia and particularly hereditary …
-
The effect of EGFL7 on the TGF-β/BMP family
Meðgöngueitrun er sjúkdómur sem u.þ.b. 2-8% kvenna fá meðan a meðgöngu stendur og getur sjúkdómurinn verið lífshættulegur bæði móður og barni. Talið er að sjúkdómurinn stafi af afbrygðilegri fylgjumyndun, en í eðlilegri fylgjumyndun undirgangast næriþekjufrumur (e. Trophoblast cells) …
-
Probing early human embryonic development to characterize BMP signaling stimulators
Bone morphogenetic proteins (BMPs) sind sowohl in der Embryonalentwicklung als auch im adulten Organismus von entscheidender Bedeutung. Da ein fehlregulierter Signalweg mit zahlreichen chronischen und schwerwiegenden Krankheiten assoziiert ist, stellt dessen Modulierung einen vielversprechenden …
-
Evaluation of stormwater BMP alternatives in the Malden River Watershed
… green infrastructure Best Management Practices (BMPs) in the Malden River watershed. The WERF BMP SELECT model was used to generate performance and cost data for bioretention systems, swales, permeable pavement, and constructed wetlands in a portion of the Malden River watershed. Due to space …
-
SOSTDC1: A BMP/Wnt Dual Antagonist in Breast and Renal Cancers
ABSTRACT Blish, Kimberly Rose SOSTDC1: A BMP/WNT DUAL ANTAGONIST IN BREAST AND RENAL CANCERS Dissertation under the direction of Suzy V. Torti, Ph.D., Associate Professor of Biochemistry The bone morphogenetic protein (BMP) pathway and the Wnt pathway are signaling networks associated with …
-
Spatio-temporal investigation and quantitative analysis of the BMP signaling pathway
Bone Morphogenetic Proteins (BMPs) are key regulators for a lot of diverse cellular processes. During embryonic development these proteins act as morphogens and play a crucial role particularly in organogenesis. BMPs have a direct impact on distinct cellular fates by means of …
-
BMP Signaling through BMPR1A is Required for Establishment of Pancreatic Laterality
… Various bone morphogenetic proteins (Bmps) and Bmp receptors (Bmprs) are expressed in the pancreas and in the tissues that flank the pancreatic bud during pancreatic development. Bmp7, BmpR1a, and BmpRII are expressed in the pancreatic endoderm during pancreatic bud development. Bmp2, …
-
BMP Signaling Regulates Germ Cell Pluripotency, Sexual Differentiation, and Cancer Susceptibility
… recent GWAS study [3] identified association of BMP7 with testicular dysgenesis syndrome; however the molecular mechanisms behind this association remain unknown. Previously, we described the development of testicular germ cell tumors in zebrafish carrying a mutation in bmpr1bb, a BMP family …
-
THE ROLE OF BMP SIGNALING AND ENDOGLIN IN REGULATION OF HEMATOPOIESIS
… candidates, Bone Morphogenetic Proteins (BMP) and Endoglin in adult hematopoiesis. Several publications have described the importance of BMP signaling in specification of hematopoietic tissue in developing embryos. In Article I and II, we investigate the full role of BMP signaling in adult …
-
Body Size Regulation via BMP Signaling in <i>Caenorhabditis elegans</i>
… a homolog of Bone Morphogenetic Proteins (BMP) is a major regulator of body size; functional loss of DBL-1 leads to a small body size. Due to a drastic change in body size in dbl-1 mutants, we have the advantage of studying body size as a monogenic trait and we are able to investigate the …
-
Bmp proteins in urodele myotube cell cycle re-entry and in regeneration
… prior incubation with thrombin. We identified Bmp proteins as the first pure molecules that were found in fractions across the purification of the activity and that could also induce cell cycle re-entry in a dose-dependent manner when recombinantly added to the A1 myotubes. Furthermore, this …
-
Agricultural BMP Placement for Cost-effective Pollution Control at the Watershed Level
… procedure for best management practice (BMP) placement at the watershed level. The procedure combines an optimization component, written in the C++ language, with spatially variable nonpoint source (NPS) prediction and economic analysis components, written in the ArcView geographic …
-
Bone morphogenetic protein (BMP-7) και μοριακά δίκτυα δυνητικών stem κυττάρων στον νεφρό
Η BMP-7 αποτελεί μόριο κλειδί κατά την εμβρυογένεση στον νεφρό, ενώ μετέπειτα, θεωρείται νεφροπροστατευτικός παράγων. Ο νεφρός χαρακτηρίζεται από μία μοναδική πλαστικότητα μεταξύ επιθηλιακών και μεσεγχυματικών κυττάρων. Κατά την ανάπτυξη του Νεφρού, το επιθήλιο του νεφρώνα δημιουργείται μέσω της …
Page 1 of 18