Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 28 for “"BECLIN"”.
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Biochemical and Genetic Studies of Beclin 1 Function in Autophagy
<p>Beclin 1 is a mammalian autophagy protein and has important functions in development, tumor suppression and neurodegeneration. Beclin 1 exists in a protein complex with Vps34, which is a class III phosphatidylinositol (PtdIns) 3-kinase and mediates multiple vesicle trafficking pathways including …
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Role of BEC-1/Beclin 1 and Autophagy Genes in <i>C.elegans</i> Germline Cell Proliferation
… the <em>C. elegans</em> ortholog of human BECN1/Beclin 1, an essential autophagy regulator and tumor suppressor protein. We show that basal levels of autophagy are required for germline proliferation and that autophagy genes are necessary for the timely progression of the cell cycle. …
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The Regulation of Autophagy and Its Role in Mitotic Exit
… regulation of a major phosphorylation site of Beclin 1, serine 90. In the first study, we found that the in response to starvation, autophagy-deficient yeasts failed to arrest properly in G1/G0, but arrested in telophase with a quiescent-specific phenotype. In a second study, we found that …
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Doxorubicin Inhibits Cardiomyocyte Autophagic Flux by Suppressing Lysosomal Acidification
… activity due to haploinsufficiency for Beclin 1. Beclin 1+/- mice exposed to doxorubicin manifested restored cardiac autophagic flux, and were protected in terms of structural and functional changes within the myocardium. Conversely, animals over-expressing Beclin 1 manifested an …
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Activation of lipid kinase VPS34 by Rab GTPases
… Complex I consists of VPS34, VPS15, Beclin 1 and ATG14L, whereas complex II contains UVRAG instead of ATG14L. VPS34 complex activity is regulated by membrane properties and by members of the Rab family of small G proteins, which are important for orchestrating intracellular vesicle …
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Expression of Markers for Autophagy and Necroptosis in Colorectal Carcinoma // Експресия на маркери за автофагия и некроптоза при дебелочревен карцином
… ролята на експресията на маркера за автофагия – Beclin-1 и за некроптоза – RIP3 във връзка с клинико-патологичните показатели и общата преживяeмост при пациенти с КРК. В настоящото проучване са включени общо 107 пациенти с диагноза аденокарцином на дебело черво. Диагнозата и стадият на тумора са …
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Investigating alterations in autophagy in Alzheimer’s disease using human brain tissue and skin-derived fibroblasts
… the assessment of cellular distribution of LC3, Beclin-1 (markers of MA) and LAMP2A, Hsp70 (markers of CMA). Neurofibrillary tangles and amyloid plaques were also assessed via immunohistochemistry. Skin-derived fibroblasts from AD patients were also used to test the cells potency to become …
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Autophagy mechanisms in sputum and peripheral blood cells of patients with severe asthma: a new therapeutic target
… (HCQ) were used. Knockdown of ATG5 and Beclin-1 was performed in A549 cells, and the therapeutic effects of dexamethasone were evaluated. Results: Higher autophagy levels were noted in sputum granulocytes, PBCs, and PBEs from patients with severe asthma than from patients with non-severe …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… stimulated the dissociation of Bcl-2/beclin 1 heterodimers, enabling beclin 1 to initiate autophagy. Moreover, phosphorylation of both JNK and Bcl-2 was observed in human glioma xenografts after infection with the oncolytic, tropism-enhanced Delta-24-RGD adenovirus, which is currently …
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Characterisation of phenotypes of inflammation, fibrosis and remodeling in chronic rheumatic heart disease using multiparametric cardiovascular magnetic resonance and autophagy markers
… study, we analysed the immunoexpression of Beclin, LC3, p62, BAX, Bcl-2 and caspase-3 in patients confirmed with RHD and valvular heart disease
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A ROLE OF PRL-3 IN AUTOPHAGY AND ITS REGULATION IN HUMAN CANCERS
… I SHOWED PRL-3 OVEREXPRESSION ENHANCES HVPS34-BECLIN-1-DEPENDENT AUTOPHAGOSOME FORMATION, AND ACCELERATES ATG5 DEPENDENT LC3 CONVERSION. PRL-3 OVEREXPRESSION ALSO ACCELERATES THE DEGRADATION OF SQSTM/P62, WHICH IS A KNOWN AUTOPHAGY SUBSTRATE. SURPRISINGLY, PRL-3 ITSELF IS ALSO DEGRADED BY …
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Repurposing Alzheimer’s disease medications in a drug combination for the study of the crosstalk between cell apoptosis and autophagy in the modulation of cell death in chronic myeloid leukaemia
… K-562 cells, the autophagic proteins, Beclin-1 (p < 0.05) and LC3 (p < 0.001), were also upregulated. With the addition of Chloroquine (10 μM), a known autophagy inhibitor, these autophagic activities were verified as being involved in the induction of cell death in the CML cells. When …
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Investigating systemic effects of chronic stress on hepatic and cardiac tissue in female Wistar rats
… Autophagy-related proteins (p62, LC3B, Beclin-1, SNAP29, SOD1/2) were quantified by Western blotting. CRS induced mild oxidative damage restricted to cardiac tissue, with reduced SOD activity and elevated compartmental malondialdehyde, while hepatic redox parameters remained unaltered. …
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Autophagy in Antiviral Immunity
… interacted with the host autophagy protein Beclin 1, and that this interaction was essential for HSV-1 neurovirulence. This was the first example of a viral virulence protein that targets host autophagy, and provided evidence that autophagy functions in innate immunity to viruses. In the …
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The Role of Mir-34A In Inhibition of Prostate Tumor Growth In The Bone and Induction of Autophagy
… autophagy that is independent of ATG5, ATG7 and Beclin-1 expression.</p> <p>In summary, studies in this dissertation provide evidence for IGF-1/1R induced ligand-independent MET activation, suggesting that cross talk among receptors may be responsible for resistance to targeted therapies. To …
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The Therapeutic Role of LM11A-31 (a p75NTR Modulator) in the Outcome of Ischemic Stroke and HIV-1 Pathogenesis
… LM11A-31 did not alter the protein level of Akt, Beclin-1, and oxidative stress enzymes, including SOD-1 and catalase. Overall, this study provides new insights into the efficacy of LM11A-31 in treating both ischemic stroke and HIV-1 infection. HIV-1-infected individuals are more suspectable to …
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PROGRAMMED DEATH LIGAND 1 (PD-L1) IMMUNE CHECKPOINT-MEDIATED STIMULATION OF MALIGNANT PHENOTYPES IN TUMOUR CELLS
… protein 1A/1B-light chain 3 (LC3)-II, and Beclin-1, as well as increased autophagosome formation. Using autophagy inhibitors, we showed that drug resistance induced by reverse PD-1/PD-L1 signaling is causally linked to increased autophagy. In addition, results of our studies demonstrated a …
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The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
… proteins p-mTOR, Atg5, Atg7, and p-Bcl-2/Beclin-1 were determined by using selective inhibitors and siRNAs. In addition, we determined the role of autophagy in chronic cocaine exposure using MTT assay and western blot analysis. In the second chapter, the effect of methamphetamine on …
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Mechanism of mitochondrial respiratory dysfunction by oncogenic K-Ras
… such as autophagy-related gene5 (Atg5), Beclin 1, microtubule-associated protein 1 light chain 3-II (LC3-II), and vacuolar adenosine tri-phosphatases (VoATPase). The respiratory protein expression and respiratory activity were recovered by blocking autophagy with conventional inhibitors …
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