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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

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Showing 1 to 20 of 172 for “"BCR"”.

  1. B cell regulation by BCR signaling

    Rui, Lixin2003

    aus-cath Repository record

  2. B cell regulation by BCR signaling

    Rui, Lixin2003

    anu Repository record

  3. The analysis of B cell antigen receptor (BCR) mutants deficient in antigen-independent signaling reveals novel BCR-associated proteins

    Pracht, Catrin

    The B cell antigen receptor (BCR) is composed of the membrane-bound immunoglobulin (mIg) <br>and the Ig-alpha/Ig-beta heterodimer and plays a central role in development, survival, and activation <br>of B lymphocytes. During B cell development, the BCR seems to be able to generate signals in <br>an …

    freiburg-diss Repository record

  4. Src-Kinasen als Mediatoren Bcr-Abl-induzierter Leukämien

    Warmuth, MarkusLudwig-Maximilians-Universität

    Bcr-Abl, eine onkogene Tyrosinkinase, ist maßgeblich an der Entstehung der chronischen myeloischen Leukämie (CML) sowie einem Teil der Fälle von akuter B-lymphoblastischer Leukämie (B-ALL) beteiligt. Die essentielle Rolle der Kinase-Aktivität von Bcr-Abl für dessen leukämogenes Potential konnte in …

    lmu-germany Repository record

  5. Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia

    Miller, Christopher B.2016

    … translocations including the t(9,22)[<em>BCR-ABL1</em>], t(1,19)[<em>TCF3-PBX1</em>], t(12,21)[<em>ETV6-RUNX1</em>], <em>MLL</em>rearranged leukemia’s, hyperdiploid and hypodiploid karyotypes, and T-lineage leukemia. Each translocation confers a characteristic transforming phenotype within …

    tenn-hsc Repository record

  6. The analysis of Bcr-Abl—Nox signalling in chronic myeloid leukaemia

    Landry, William D.University College Cork2013

    … following generation of the chimeric protein Bcr-Abl, a constitutively active tyrosine kinase which induces oncogenesis in part by promoting increased cell survival and proliferation. Since the development of Bcr-Abl-specific tyrosine kinase inhibitors (TKIs) there has been a substantial …

    cork Repository record

  7. Multilineäre Beteiligung der Leukämogenese in der BCR::ABL1-like Akuten Lymphoblastischen Leukämie

    Amelunxen, Eric LeanderChristian-Albrechts-Universität zu Kiel

    … in der Leukämogenese ist für die BCR::ABL1-positive ALL gut beschrieben und stellt einen potenziellen Resistenzmechanismus gegenüber B-Zell-spezifischen Therapien dar. Die biologisch verwandte BCR::ABL1-like ALL ist eine Subgruppe mit bislang unzureichend erklärter Leukämogenese. …

    cau-kiel Repository record

  8. Capacidade proliferativa de células progenitoras BCR/ABL - positivas durante o cultivo in vitro

    Cordero, Elvira Alicia Aparicio2003

    Resumo não disponível.

    brazil-ufrgs Repository record

  9. DNA als diagnostiek bij CML : kwantificering van het BCR-ABL mRNA in CML

    Kuypers, A.W.H.M.1993

    eindhoven Repository record

  10. Pre-BCR signaling amplifies antibody diversity by activating secondary immunoglobulin heavy chain gene rearrangement

    Khadour, AhmadUniversität Ulm

    ulm-diss Repository record

  11. Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia

    Singh, Harpreet2016

    … signaling by the Philadelphia chromosome-encoded BCR-ABL fusion kinase initiates and drives both Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myelogenous leukemia (CML). Food and Drug Administration (FDA)- approved BCR-ABL-specific kinase inhibitors …

    tenn-hsc Repository record

  12. Quantification of Major BCR-ABL1 Fusion Gene Transcripts for Monitoring Therapeutic Response to Tyrosine Kinase Inhibitors in Chronic Myelogenous Leukemia; Comparison of LightCycler t(9;22) Quantification Kit and BCR-ABL1 Mbcr IS-MMR Dx Kit.

    안, 선현2013

    … (Ph) and the corresponding fusion gene, BCR-ABL1. For disease monitoring, standardize BCR-ABL1 quantification and International Scale (IS) has been suggested, and this study is to compare IS-based IS-kit with non-IS-based LightCycler-t(9;22) Quantification kit (LC kit; Roche, Germany) for …

    ajou Repository record

  13. Bedeutung der Rezeptor-Tyrosinkinase c-Kit in der Pathogenese der, Philadelphiatranslokation Bcr-Abl positiven, chronischen myeloischen Leukämie

    Konieczny, AndreasLudwig-Maximilians-Universität

    … Rezeptor-Tyrosinkinase c-Kit mit dem Onkoprotein Bcr-Abl. Es wird in der zeitlichen Abfolge der chronisch myeloischen Leukämie (CML) besonders für die chronische Phase eine Beteiligung des Stammzellfaktors (SCF), dem natürlichen Liganden von c-Kit, an der Proliferation des malignen Zellklons …

    lmu-germany Repository record

  14. Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia

    Zhang, Hui2013

    … constitutively active protein-tyrosine kinase BCR-ABL, which is encoded by <em>BCR-ABL</em> fusion gene as the result of chromosome 9/22 translocation (Philadelphia chromosome). Previous studies have demonstrated that oxidative stress-associated genetic, metabolic and biological alterations …

    uthsc Repository record

  15. Functional interaction between CD180 Toll-like receptor (TLR) and B cell receptor (BCR) in the biology of Chronic Lymphocytic Leukaemia (CLL)

    Rajakaruna, A.University of Westminster2017

    … unknown (auto)antigens via the B cell receptor (BCR) and growth, survival and expansion signals it receives from the microenvironment through a range of cytokines and receptors, including Toll-like receptors (TLR). The role of the microenvironment in the development and progression of CLL is …

    westminster Repository record

  16. Vitamin D Levels Affect Survival in a BCR-ABL Acute Lymphoblastic Leukemia Mouse Model but Do Not Cause Vitamin-Drug Interactions

    Annu, Kavya2021

    … on survival outcome from pre-B cell Arf -/- BCR-ABL acute lymphoblastic leukemia in a murine model. Vitamin D sufficient mice died earlier (p</p> <p>To investigate the mechanism by which vitamin D affected the survival and disease growth in VD3 sufficient mice, we performed in vitro studies …

    tenn-hsc Repository record

  17. Étude de l'influence de l'entraînement de l'air sur la maniabilité et la résistance à la compression des bétons compactés au rouleau

    Houehanou, Ernesto CUniversité de Sherbrooke2004

    … Amérique du Nord, le béton compacté au rouleau (BCR) contient habituellement de l'air entraîné pour la protection contre les dommages provoqués par les cycles de gel-dégel. L'air entraîné améliore la durabilité au gel du BCR, mais il affecte également les propriétés du BCR à l'état frais et à …

    sherbrooke Repository record

  18. B Cell Receptor Signalng in Germinal Centers

    Chen, Spencer T

    … antigen capture function of the B cell receptor (BCR). However, the BCR can also function as a signaling entity, and it is not well understood how signaling by the B cell receptor contributes to selection. The critical barriers to addressing this question have been a lack of specific BCR signaling …

    rockefeller Repository record

  19. Targeting the B-Cell Receptor in Diffuse Large B-Cell Lymphoma

    Corcoran, SeanUniversity of Cambridge2023

    … all DLBCL tumours express a B-cell receptor (BCR), which is a cell surface antigen receptor of immunoglobulin in tandem with the signalling adapters CD79A and CD79B. Over the last 2 decades, the importance of signals emanating from the BCR have gained prominence in how we understand oncogenic …

    cambridge Repository record

  20. The proteomic analysis of B-cell receptor signaling in chronic lymphocytic leukaemia

    Eagle, Gina L.University of Hull2009

    … mutated IgVH genes on the B-cell receptor (BCR) have a good prognosis, whereas patients who express unmutated IgVH genes have a poor prognosis. However IgVH gene mutational status is an expensive and time consuming test and would not be practical for routine clinical practice. If the B-cell …

    hull Repository record

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