Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 130 for “"BCG"”.
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The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination
Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low …
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BCG-specific T cell proliferation and cytotoxic capacity in infants as risk of tuberculosis disease, following newborn BCG vaccination
BCG is the only vaccine against tuberculosis and has been used for over 90 years. BCG efficacy is variable, especially in countries with high TB prevalence, where over a million deaths due to tuberculosis, are still reported annually. New TB vaccines are under development to either replace or boost …
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Cellular immunity of naïve and BCG vaccinated neonates
… Mycobacterium bovis Bacille Calmette-Guérin (BCG), tuberculosis (TB) remains epidemic in South Africa. The dichotomy that successful pregnancy is usually associated with a type 2 (Th2) cytokine profile in the newborn child, whereas immunity to Mycobacterium tuberculosis (Mtb) is associated …
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Searching for Extreme-BCG Clusters at 0.2 < z < 1.3
… my Ph.D. thesis, I show that by finding extreme-BCG clusters we can better understand the processes of cluster formation and evolution. In the first part of my thesis, I conduct an optical survey to discover new extreme-BCG clusters at low redshift. Finding clusters with distinct properties from …
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Novel Mechanisms of Antigen Processing That Enhance Bcg Vaccine Efficacy
… to prevent this disease. The current vaccine, BCG, has a variable efficacy and does not protect adults. It is known that BCG vaccine becomes sequestered in special phagosome compartments of macrophages that do not fuse with lysosomes. Since lysosome fusion is necessary for peptide production …
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Immunological insights into healthy aging: BCG vaccination and other strategies
Contains fulltext : 312649.pdf (Publisher’s version ) (Open Access)
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Local immunopotentiation of the bladder in response to BCG immunotherapy
Although intravesical Bacillus Calmette-Gu??rin (BCG) therapy for superficial bladder cancer is the most successful example of cancer immunotherapy, much remains unknown about its mechanisms of action.Using a standardized protocol for measuring urinary cytokines, we noted that BCG induces a mixed …
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Association between BCG-induced immunity and risk of TB disease
… and profile of specific T cells induced by BCG vaccination at birth is associated with subsequent risk of developing tuberculosis.
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Strategies to improve BCG-mediated protection from <i>Mycobacterium tuberculosis</i>
… antigen 85A (MVA85A), strongly boosted BCG-induced antigen 85A specific- CD4<sup>+</sup> and CD8<sup>+</sup> T cell responses in BALB/c and C57BL/6 mice. A comparison of intranasal and parenteral immunisation of BCG showed that whilst both routes elicited comparable T cell responses in …
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The development of novel HIV-1 vaccines using modified recombinant BCG
… novel HIV-1 vaccine vectors, such as modified BCG, combined with modified vaccinia Ankara in the context of heterologous prime boost regimes. The tuberculosis vaccine Bacillus Calmette–Guérin (BCG) has a wellestablished safety profile as well as notable adjuvant activity with an estimated 3 …
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Untersuchung der lokalen und systemischen Immunantwort nach intravesikaler BCG-Behandlung des oberflächlichen Harnblasenkarzinoms
… systemischen Immunantwort nach intravesikaler BCG-Behandlung des oberflächlichen Harnblasenkarzinoms. <br>Material und Methoden: Insgesamt 37 Patienten mit oberflächlichen Harnblasenkarzinomen der Stadien Ta bis T1b erhielten 6 wöchentliche BCG-Instillationen nach transurethraler Resektion des …
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Effects of delayed BCG vaccination on cellular immune responses in HIV-exposed infants
Includes abstract. Includes bibliographical references.
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Investigation of recombinant BCG as a vector to deliver HPV-11 L1 vaccines
Bibliography: leaves 147-175.
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Recombinant BCG expressing rotavirus VP6 : construction and evaluation as an anti-rotavirus vaccine
Bibliography: leaves 188-207.
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Possible associations between incidence of tuberculosis in Varna region and from the effects of BCG vaccine // Възможни асоциации между заболеваемостта от туберкулоза в регион Варна и ефекта от приложената BCG ваксина
… на туберкулоза и въпреки задължителната BCG имунизация се наблюдава бавно нарастване на заболяемостта от туберкулоза при децата. Разпространението и честотата на заболяването са тясно свързани с инфектираността и имунологичния статус на населението в даден район. Настоящият труд акцентира …
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Correlates of risk of TB disease in infants with differential response to BCG vaccination
… correlates of risk of TB disease following BCG vaccination is an important first step towards determining correlates of protection against TB, which can be identified only in a placebo-controlled randomized controlled trial (RCT) of an effective vaccine. To study correlates of risk of TB …
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Changes in the BCG-Induced T cell response over the first year of life
Bacille Calmette-Guerin (BCG), the only currently available tuberculosis vaccine, is the most widely administered vaccine in the Expanded Programme on Immunisation (EPI). Despite this, many gaps in our knowledge of BCG-induced T cell responses exist. The primary objective of this study was to …
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Evaluation of a reverse tetracycline inducible system in recombinant BCG to improve stability and immunogenicity
… down-regulate recombinant antigen expression in BCG during the expansion of seed stocks and up-regulate expression prior to or post vaccination.
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Optimisation of a flow cytometry antibody panel to detect BCG-induced innate responses in infants
… (HIV) and previous Bacillus Calmette–Guérin (BCG) vaccination. As it stands, other than inborn errors in key mycobacterial susceptibility genes both animal and human studies have not found many genetic polymorphisms that are strongly and reproducibly associated with increased mycobacterial …
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