Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"B(a)P"”.
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Effect of Dietary Factors on Mutagenesis, Metabolism, and Binding to DNA of Benzo [a] pyrene and Benzo [a] pyrene 7, 8-dihydrodiol
<p>Ellagic acid (EA), a naturally occurring plant phenol, at concentrations of 5 to 50 pg/plate, inhibited rat liver S9 protein dependent benzo[a]pyrene (B[a]P)-induced mutagenesis in Salmonella typhimurium TA 100 by 30-81% and B[a]P 7,8-dihydrodiol (DHD)-induced mutagenesis by 29 to 75%. EA (5-40 …
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The metabolic fate of benzo [a] pyrene in vivo
[³H]-B[a]P absorption, distribution, metabolism, excretion and macromolecular binding in male Sprague-Dawley rats were investigated following administration by intratracheal instillation through a cannula. [³H]- radioactivity in various organs was determined at timed intervals between 5 and 360 …
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New insights into the mechanism of dna replication on unmodified and benzo[a]pyrene modified templates using surface plasmon resonance
<p>DNA synthesis is critical to cell survival, and the enzyme DNA polymerase has had a great deal of time to evolve efficient strategies to perform synthesis. A variety of effects are induced by the identity of the incoming dNTP, and its ability to effectively base pair with the templating base. …
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In vivo and in vitro applications of biospectroscopy : potential use as a diagnostic tool which can provide insights into cell cycle dependent proliferation
Biospectroscopy and its applications characterise in vitro and in vivo cells with abnormal proliferation capacities. Proliferation of endometrial tissues in regions other than the uterus lining is known as endometriosis. It affects around 10% of women in the UK and worldwide. This study tests …
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Einfluss der Aufnahmewege auf die Toxikokinetik von Terbutryn und Benzo[a]pyren bei drei benthischen Invertebraten
Im Rahmen dieser Arbeit sollte geprüft werden, welchen Einfluss die Aufnahmewege Wasser und Nahrung auf die Toxikokinetik der 14C-markierten Testsubstanzen Terbutryn und Benzo[a]pyren bei den aquatischen Invertebraten Gammarus fossarum, Asellus aquaticus und Lumbriculus variegatus haben. Es wurden …
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Contrasting Effects of An Mdm2 Functional Polymorphism On Tumor Phenotypes
<p>Cancer predisposition by the cooperation of genetic variants, such as single nucleotide polymorphisms (SNPs), may be of much greater significance to public health than previously appreciated. Functional polymorphisms are genetic variants that alter gene function. Meta-analyses associate many …
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Characterization of P-glycoprotein expression as a multixenobiotic resistance mechanism in fish
Transmembrane P-glycoproteins (P-gps) are responsible for multidrug resistance (MDR) phenotypes in tumor cell lines. P-glycoproteins function as energy dependent efflux flippases that prevent the cellular accumulation of a wide variety of compounds. We characterized P-gp expression in populations …
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The Development and Application of a Hemolytic Plaque Forming Cell Assay (PFC) and a Cytotoxic T-Lymphocyte Assay (CTL) in Tilapia (Oreochromis niloticus) for Immunotoxicity Risk Assessment of Environmental Contaminants
The prospect of utilizing the cichlid teleost tilapia (Oreochromis niloticus) as an alternative experimental model to mammals for immunotoxicity risk assessment is currently being proposed. As such, the National Toxicology Program's (NTP) standard battery of rodent immunotoxicity assays is being …
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Analysis of the aryl hydrocarbon receptor and a truncated form (AHR C[upper case symbol for greek Delta]Δ553) in cancer cells
<p>The aryl hydrocarbon receptor (AhR) is a ligand-activated bHLH-PAS protein that binds its partner, the aryl hydrocarbon receptor nuclear translocator (Arnt), in the nucleus to initiate the expression of proteins involved with detoxification. Published work suggests cross-talk between both …
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Immortalisierung embryonaler Fibroblasten aus Wildtyp und Hupki (Human p53 knock-in) Mäusen durch Veränderungen des p19Arf/p53 Kontrollweges und Erst-Charakterisierung des neuen Prolin 72-kodierenden Hupki-Mausstamms
Aufgrund zunehmenden Wissens um die Regulation des Wachstums maligner Zellen können neue Therapieansätze gefunden werden. Dafür ist es notwendig, mehr über die komplexen Mechanismen der Tumorentstehung und der unbegrenzten Proliferation, der Immortalisierung, von Zellen zu wissen. Immortale Zellen …
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Ricerca, mediante tecniche di proteomica, di biomarcatori proteici utili nella valutazione della qualità degli alimenti di origine animale
In the last decades, the increase of industrial activities and of the request for the world food requirement, the intensification of natural resources exploitation, directly connected to pollution, have aroused an increasing interest of the public opinion towards initiatives linked to the …
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Effects of plant flavonoids on the fate of polynuclear aromatic hydrocarbons in rhizosphere soil
High-molecular-weight polynuclear aromatic hydrocarbons (PAHs) are persistent in the environment although a wide variety of microorganisms can metabolize PAHs. In the past decades, laboratory and filed studies have shown that PAH degradation in soil is often limited by poor bioavailability and …
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Acute Toxicity and Sub-Lethal Effects of Non-Point Source Pollutants on Invertebrates
Non-point source pollution is not generated from any single source, rather can arise from a mixture of agricultural, residential, and industrial activities. As a result of these activities millions of tons of chemicals enter into aquatic environments annually with the potential to disrupt the …
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Anticarcinogenic, Antitumor, and Antifungal Properties of Allium Sativum (Garlic)
<p>In this study the antimutagenic/anticarcinogenic, immune enhancing, antitumor and antifungal effects of a crude extract and organosulfur compounds of garlic were determined. Diallyl sulfide (DAS), and ajoene each at 100 /xg/ml, and garlic extract (GE, 12.5 mg/ml) inhibited rat liver 9000 X g …
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Determination of genotoxic stress in feral populations of bullheads and carp using the alkaline single cell gel assay.
Monitoring genotoxicity of the environment using endemic organisms as sentinels requires the development of sensitive assays. Towards this end, I explored the feasibility of applying the ALKALINE SINGLE CELL GEL (SCG) or "COMET" ASSAY. This approach involves detection, under alkaline conditions, of …
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Resistência de bactérias isoladas em amostras de internos detectadas em um laboratório privado da cidade de João Pessoa
11 S Á , L . S . R e s i s t a n c e o f b a c t e r i a i s o l a t e d f r o m i n t e r n a l s a m p l e s d e t e c t e d i n a p r i v a t e l a b o r a t o r y J o ã o P e s s o a c i t y . 49 f . 2 0 1 5 . M o n o g r a p h ( U n d e r g r a d u a t e ) - P h a r m a c y S c h o o l , F e d …