NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 37 for “"Autoinducer"”.

  1. The synthesis and biological evaluation of a library of autoinducer-antibiotic conjugates

    Overvoorde, Lois MayUniversity of Cambridge2018

    … using a similar approach, but using bacterial autoinducers instead of siderophores. Autoinducers are required for coordination of bacterial behaviours and are involved in the control of swarming, virulence factor production and biofilm formation. The quorum sensing molecules produced by …

    cambridge Repository record

  2. Autoinducer-2-based quorum sensing of foodborne pathogenic bacteria under food related conditions

    Yoon, Yohan, author, Sofos, John, advisor, Kendall, Patricia, advisor, Ellis, Robert P., committee member, Scanga, John, committee memberColorado State University. Libraries2006

    … studies was to evaluate potential involvement of autoinducer (AI)-2-based quorum sensing (quorum sensing: cell density dependent cell-to-cell signaling) of foodborne pathogenic bacteria in food environments. Under the conditions of these studies, AI-2 activity of Salmonella and Escherichia coli …

    colostate Repository record

  3. The quorum-sensing regulation of Vibrio fischeri : novel components of the autoinducer/LuxR regulatory circuit

    Callahan, Sean M.Massachusetts Institute of Technology and Woods Hole Oceanographic Institution1999

    … low population density by C8-HSL. Probable LuxR/autoinducer binding sites are found in the promoter region of each. QsrP and RibB are encoded monocistronically, whereas AcfA and QsrV appear to be encoded by a two-gene operon. On the basis of sequence similarity to proteins of known function from …

    woods-hole Repository record

  4. Mutant analysis of luminescence and autoinduction in a marine bacterium

    Kuo, Alan J.Massachusetts Institute of Technology and Woods Hole Oceanographic Institution1994

    … is mediated by a signal molecule called the "autoinducer". The mechanistic bases of both luminescence and autoinduction are well known in V. fischeri, but this knowledge is mostly derived from studies of the cloned luminescence and autoinduction genes expressed in Escherichia coli. In this …

    woods-hole Repository record

  5. Role of region 4 of the sigma 70 subunit of RNA polymerase in transcriptional activation of the lux operon during quorum sensing

    Johnson, Deborah CumaraswamyVirginia Tech2002

    … relies on the formation of a complex between the autoinducer molecule, N-(3-oxohexanoyl) homoserine lactone, and the autoinducer-dependent transcriptional activator LuxR. LuxR, a 250 amino acid polypeptide, binds to a site known as the lux box centered at position -42.5 relative to the luxI …

    vt Repository record

  6. Structural and functional elucidation of four putative PQS-binding proteins in Pseudomonas aeruginosa

    Grimm, LarsonUniversity of Cambridge2023

    … *rhl*, and *pqs* systems rely on a receptor-autoinducer relationship: these receptor-autoinducer complexes are LasR-OdDHL, RhlR-BHL, and PqsR-PQS, respectively. When the receptors (LasR, RhlR, PqsR) bind with their cognate autoinducer (OdDHL, BHL, PQS, respectively), they act as transcription …

    cambridge Repository record

  7. Amino Acid Residues in LuxR Critical for its Mechanism of Transcriptional Activation during Quorum Sensing

    Trott, Amy ElizabethVirginia Tech2000

    … an acylated homoserine chemical signal (autoinducer) is synthesized by the bacteria and used to sense their own species in a given environment. As the autoinducer levels rise, complexes form between the autoinducer and the N-terminal domain of a regulatory protein, LuxR. In response to …

    vt Repository record

  8. Mathematical Models of Quorum Sensing

    Ueda, Hana2016

    … communication are mediated by molecules called autoinducers that are both synthesized and collected by quorum sensing bacteria. We employ differential equations to investigate and understand the dynamics of underlying signaling processes. The first two models of this study were constructed with …

    maryland Repository record

  9. Biochemical Assay Optimization and Computational Screening Efforts to Identify Potential LuxS Inhibitors

    Wang, Keeshia Q2015

    … QS is regulated by the small signaling molecule autoinducer-2 (AI-2) and is implicated in the infectious behaviors of various bacterial species. AI-2 is biosynthesized from <em>S-</em>ribosylhomocysteine (SRH) by the enzyme LuxS and induces interspecies cell-to-cell communication. Inhibition of …

    usfca Repository record

  10. The Influence of Changes In theMolecular Structure of N-Acylhomoserine Lactones On the Complexation and Dna-Binding of Luxr Protein

    Cui, Yiling

    … to surrounding chemical signals known as autoinducers. A wide range of Gram-negative Proteobacteria possess LuxR-type transcriptional regulatory proteins which can perceive and bind cognate autoinducer N-acylhomoserine lactones (AHLs), thereby inducing a conformational change and …

    south-carolina Repository record

  11. Role of the C-terminal domain of the <font face = "symbol">a</font> subunit of RNA polymerase in transcriptional activation of the <i>lux</i> operon during quorum sensing

    Finney, Angela H.Virginia Tech2000

    … the presence of an acylated homoserine lactone autoinducer molecule (3-oxo-hexanoyl homoserine lactone). LuxR, which binds to the <i>lux</i> operon promoter at position -42.5, is thought to function as an ambidextrous activator making multiple contacts with RNA polymerase (RNAP). The specific …

    vt Repository record

  12. Intercellular communication in uropathogenic Escherichia coli and the probiotic Lactobacillus reuter

    Elwood, Chelsea NicoleThe University of Western Ontario2006

    … This study sought to characterize the role of autoinducer 2 (AI-2) in the regulation of virulence factors of uropathogenic Escherichia coli J96, determine if the probiotic Lactobacillus reuteri RC-14 produced AI-2, and evaluate if secreted products from the probiotic could affect pathogen …

    uwo Repository record

  13. Survival and recovery of Escherichia coli O157:H7 during starvation at sub-optimal temperatures

    Xavier, Ron NeoUniversity of Waikato2014

    … on agar. The role of quorum sensing (LuxS/autoinducer-2) on starved cell recovery was investigated by supplementing PCA with quorum sensing molecules and using a mutant strain deficient in luxS, a gene encoding the synthase of autoinducer-2. The ability of starved and non-starved cells to …

    waikato-masters Repository record

  14. Synthesis of S-Ribosyl-L-homocysteine and Analogs Modified at the Homocysteine-C3 Position

    Liu, Ruoyi2012

    … (DPD), which is the precursor of autoinducer-2 (AI-2). Thus, inhibitors of LuxS could prevent QS by halting the conversion of SRH to AI-2 rendering the cell “uncommunicative”. This work shows the successful chemical synthesis of SRH and progress towards the synthesis of SRH analogs …

    usfca Repository record

  15. HAEMOPHILUS INFLUENZAE AND MORAXELLA CATARRHALIS INTRA- AND INTERSPECIES QUORUM SIGNALING

    Armbruster, Chelsie ElizabethWake Forest University2011

    … is bacterial communication via quorum signaling. Autoinducer-2 (AI-2) is termed an interspecies signal as the genetic determinant for AI-2 production (<italic>luxS</italic>) is highly conserved and many species possess the machinery to respond to AI-2. <italic>H. influenzae</italic> has a …

    wfu Repository record

  16. Mikrobielle Ökologie N-Acyl-L-Homoserinlacton-produzierender Bakterien in der Rhizosphäre von Tomatenpflanzen

    Gantner, Stephan AreLudwig-Maximilians-Universität

    … work characterised the microbial ecology of the autoinducer (AHL) producing bacteria Serratia liquefaciens MG1 and Pseudomonas putida IsoF in the rhizosphere of tomato plants. Gfp- and rfp-tagged strains of the AHL producing wiltypes S. liquefaciens MG1 and P. putida IsoF were compared with its …

    lmu-germany Repository record

  17. The Functional Characterization of QSEC a Bacterial Adrenergic Receptor and the LuxR Homologue SDIA in EHEC

    Hughes, David T.2010

    … receptor which responds to the bacterial signal autoinducer-3 (AI-3) and the host signals epinephrine and norepinephrine. EHEC senses these signals in the gut in order to coordinate expression of multiple virulence factors. These factors include the locus of enterocyte effacement (LEE) genes …

    utswmed Repository record

  18. Biochemical Evaluation of SRH Analogs as Potential LuxS Inhibitors

    gupta, richa2012

    … facilitated by small molecules called autoinducers. Interspecies quorum sensing is facilitated by the autoinducer AI-2. The enzyme LuxS catalyzes the formation of AI-2 from <em>S</em>-ribosyl homocysteine (SRH) in a wide variety of bacterial species. Inhibition of LuxS would therefore …

    usfca Repository record

  19. New Sensing Modalities for Bacterial and Environmental Phenomena

    Betz, Jordan2013

    … molecules: the universal quorum sensing molecule autoinducer-2 (AI-2), the species-specific Pseudomonas Quinolone Signal (PQS), and the stationary phase indicator molecule indole. SERS substrates were formed by galvanic displacement, a substrate fabrication method that can be adapted to many SERS …

    maryland Repository record

  20. Chemical Processes That Govern the Natural Attenuation of Microbial Signals: Environments That Simulate Photosynthetic Biofilms

    Frey, Rebecca Leeray

    … (DPD) derivatives functionally classified as autoinducer-2 (AI2). Oxidative attenuation of the acylhomoserine lactones (AHLs) by hydroxyl radicals results in the formation of keto- and hydroxo AHLs, some of which are more potent signals (per mole) than the original AHLs. In contrast, parallel …

    south-carolina Repository record

Page 1 of 2