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Showing 1 to 20 of 33 for “"Aurora A"”.
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Differential Regulation of Iress In The Aurora A Mrna By Bfgf Through The Mtor Complex to rc2 Modulates Aurora A Kinase Expression
… and proliferation. One of those proteins is the Aurora A kinase. Aurora A kinase is a member of a small family of kinases that contribute to mitotic events such as centrosome duplication, separation, and maturation. Aurora A overexpression leads to genomic instability, which can contribute to …
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Molecular Mechanism of Aurora-A Kinase in Human Oncogenesis
Aurora-A is a mitotic kinase, which regulates cell cycle progression through modulating centrosome function. Aurora-A expression is frequently altered in human malignancies. The discrepancy between overexpression and amplification suggests that elevated Aurora-A level is likely to be regulated also …
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Biochemical Context Drives Inhibitor Selectivity in Aurora A Kinase
The Aurora family of mitotic kinases control events necessary for proper separation of chromosomes throughout mitosis. The family is highly conserved and structurally similar but differs in their activation pathways and interacting partners. For example, Aurora A kinase can be activated by …
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Regulation der humanen Aurora-A Kinase und Identifikation potentieller Interaktionspartner
… is the serine/threonine-specific protein kinase Aurora-A. However, only a few interaction partners and physiological substrates of Aurora-A are know to date and the function of this important kinase is only beginning to emerge. To gain further insight in the cellular function of Aurora-A I set …
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Áhrif sértæks Aurora-A kínasahindra á brjóstaþekjufrumulínur með stökkbreytingu í BRCA2 geninu
… í eggjastokkana. Sýnt hefur verið fram á að Aurora-A kínasinn er magnaður upp í BRCA2 krabbameinum og oft þýðir það verri horfir fyrir sjúklinginn. Því eru núna miklar vonir bundnar við sértæka Aurora-A kínasahindra og tilvonandi meðferðarmöguleika þeirra í framtíðinni.
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Aurora A nuclear expression and telomere length in BRCA2 related breast cancer
… Í þessari rannsókn voru skoðuð annars vegar Aurora A yfirtjáning í brjóstaæxlissýnum og hins vegar telomere lengd í blóðsýnum frá brjóstakrabbameinssjúklingum með og án BRCA2 999del5 stökkbreytingar. Aurora A kjarnatjáning var metin með mótefnalitun á vefjaörflögum í alls 396 brjóstaæxlum, …
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Disrupting the inhibitory Kappa B kinase (IKK) - Aurora A axis in cancer
… have been proposed including the mitotic kinase Aurora A, one of three serine/threonine kinases of the Aurora kinase family that mediate mitotic progression in cells. Aurora A kinase specifically has several roles in the cell cycle, regulating spindle formation/attachment, centrosome maturation …
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A novel route to oncogenic activation of cell cycle kinase Aurora A
Aurora kinase A (AURKA) is a major positive regulator of the cell cycle, required for the onset of mitosis and the completion of cell division. Recent research has uncovered roles of AURKA that are independent of the kinase activity and that regulate multiple cellular processes, including motility, …
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Functional Regulation of Yap By Aurora A Kinase In Triple-Negative Breast Cancer
… development. In this study, we determined that Aurora A kinase acts as a positive regulator for YAP-mediated transcriptional machinery. Specifically, YAP associates with Aurora A predominantly in the nucleus. Activation of Aurora A can impinge on YAP activity through direct phosphorylation. …
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Targeting Transcription Factors in Neuroblastoma: Development of Aurora Kinase A/N-Myc Degraders and ID2 Chemical Probes
… degradation in neuroblastoma through binding to Aurora kinase A (Aurora-A). Chapters 2 – 3 will discuss the discovery of first-in-class Aurora-A/N-Myc degraders and the first proof-of-concept for targeting N-Myc with Aurora-A degraders. A highly selective and potent Aurora-A ligand 2.1 …
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Modulation of the aquaporin-2 localization in renal principal cells
… the discovery of a hitherto unknown role of aurora kinase A (AURKA) in the control of the AQP2 localization. Two AURKA-selective inhibitors, aurora-A inhibitor I and alisertib, inhibited the cAMP-dependent AQP2 redistribution in two cell models by effects on the actin cytoskeleton. Novel …
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Understanding the effect of allosteric regulation of Aurora kinases on inhibitor binding
Aurora kinase A and B regulate various signaling processes during mitosis, and their overexpression is associated with mitotic dysregulation and tumorigenesis. Many ATP-competitive inhibitors of Aurora kinases have been developed and are in various phases of clinical trials. However, the lack of …
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Characterisation of ALADIN’s function during cell division
… the spatial regulation of the mitotic regulator Aurora A kinase. Without ALADIN, active Aurora A spreads from centrosomes onto spindle microtubules, which affects the distribution of a subset of microtubule regulators and slows spindle assembly and chromosome alignment. Interestingly, mutations …
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FANCD2 in relation to BRCA2 mutated breast cancer
… inhibition treatment tolerance with alisertib Aurora-A inhibition that could work against FANCD2 activation in cells lacking BRCA2 expression. Statistical significance was found for high FANCD2 nuclear expression and low age at diagnosis, larger tumor sizes, tumor grade and increased Ki-67 …
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Funktionelle Charakterisierung der humanen Proteinkinase Aurora-C in Krebszellen
Aurora-Kinasen sind eine konservierte Familie von Serin/Threonin-Kinasen, die an der Regulation der Mitose und Meiose in eukaryotischen Organismen beteiligt sind. Die Aurora-Subfamilie in Säugern besteht aus drei Kinasen, die Aurora-A, -B und -C bezeichnet werden. Im Gegensatz zu Aurora-A und -B …
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Construction and Biological Characterisation of Custom Engineered Protein Degradation Tools.
… to conventional inhibition approaches is Aurora A (AurA). Degradation rather than inhibition of AurA should be able to block non-catalytic functions that cannot be inhibited. Event-driven pharmacology can be effected using bifunctional constructs to recruit the cell’s degradation machinery …
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Synthesis and evaluation of novel kinase inhibitors as anti-cancer agents
… tobe strongly inhibiting other kinases, namely aurora A (AURKA), p38 (MAPK14) and Hgk(MAP4K4). These compounds represent exciting potential new anti-cancer compounds dueto the fact that they inhibit cancer-associated kinases whilst displaying low cytotoxicity.
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Pulsating aurora: Source region & morphology
<p>Pulsating aurora, a common phenomenon in the polar night sky, offers a unique opportunity to study the precipitating particle populations responsible for this subtle yet fascinating display of lights. The conjecture that the source of these electrons originates near the equator, made decades …
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Investigation of mass spectrometry approaches for aiding fragment-based drug discovery
… to study the protein-protein interaction between Aurora A, an anticancer target, and TPX-2, and its inhibition using chemical compounds. In Chapter 6, the overall conclusions and outlook of this project are presented. Overall, these studies demonstrate the utility of native MS approaches in …
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Untersuchungen zur Funktion des RanGAP1 Proteins
… mitotischen Extrakten zur Identifizierung von Aurora-A als eine in vitro Kinase für Eferin. Aufgrund dieser Ergebnisse wird vorgeschlagen, dass Phosphorylierung Abbau und / oder Lokalisation von Eferin regulieren könnte.Ein zweites Projekt betraf die Regulation von RanGAP1 durch …
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