Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 16 of 16 for “"Apomorphine"”.
-
Disruption of Prepulse Inhibition by Apomorphine Across Modalities
… sensorimotor gating. It is well-established that apomorphine (APO), a dopamine agonist, disrupts PPI of the auditory startle response at low prepulse intensities (5-10 dB above baseline noise) at an interstimulus interval (ISI, time between the prepulse and the startle stimulus) of 100msec. In the …
-
Behavioural assays of the effects of antidepressant drug treatment on the functioning of catecholamine systems
… anorexic effects of low doses of amphetamine and apomorphine as assays of beta-adrenergic function and presynaptic dopamine function respectively. Anorexia was typically examined using a microstructural analysis of feeding, which was validated observationally. Amphetamine anorexia was …
-
Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΚΕΤΑΜΙΝΗΣ ΣΤΟ ΜΕΛΑΙΝΟΡΑΒΔΩΤΟ ΝΤΟΠΑΜΙΝΕΡΓΙΚΟ ΣΥΣΤΗΜΑ ΤΟΥ ΕΓΚΕΦΑΛΟΥ
THE EFFECT OF KETAMIN ON AMPHETAMINE AND APOMORPHINE INDUCED TURNING BEHAVIOURAFTER UNILATERAL STRIATAL LESIONS WERE STUDIED. THE NUCLEUS CAUDATUS OF 11 MALE WISTAR RATS WAS UNILATERALLY LESIONED BY STEREOTAXIC INJECTION OF KAINIC ACID. AFTER OPERATION, THE RATS SHOWED PORTURAL ASYMMETRY, AS WELL …
-
Behavioural microanalysis of dopamine autoreceptor function
… and axon terminals of DA neurons. Low doses of apomorphine reduced food Intake, in a microstructural analysis paradigm, by reducing both the time spent feeding and the rate of food ingestion. The reduction of eating time was shown to result from the stimulation of DA autoreceptors located on the …
-
50-kHz ultrasonic vocalizations in hemiparkinsonian rats repeatedly treated with dopaminomimetic drugs as a possible behavioral marker of the affective properties of dopamine-replacing therapy in Parkinson's disease
… (6-OHDA) in the medial forebrain bundle. Apomorphine (2 or 4 mg/kg, i.p.), L-3,4-dihydroxyphenilalanine (L-DOPA, 6 or 12 mg/kg, i.p.), or pramipexole (2 or 4 mg/kg, i.p.) were administered in a test cage (× 5 administrations) on alternate days. Seven days after treatment discontinuation, …
-
Systemic administration of putrescine induces GABA-like behaviors in rats
… on behavior induced by a dopamine agonist, apomorphine, and were compared to effects produced by a GABA agonist, muscimol. Male adult rats were given either saline, putrescine, or muscimol, and later treated with saline or apomorphine. Locomotor and specific activities were time sampled for …
-
Exercise induced neuroprotection in spontaneuosly running rats
… of the neurotoxin, the rats were injected with apomorphine and the number of ipsilateral and contralateral rotations was counted with contralateral rotations of greater than 150 considered to represent striatal dopamine neuron destruction of 70% or above.
-
Interactions between the cholinergic and dopaminergic system during the production of ultrasonic vocalizations in rats
… system. It was found that injection of apomorphine into the shell of the nucleus accumbens significantly decreased the number of carbachol-induced 22 kHz USVs from both AH-MPO and LS. Injection of carbachol into the LS significantly decreased the number of apomorphine-induced 50 kHz USVs …
-
Interazione dopamina-ossitocina nel controllo centrale della risposta erettile
… 1) the effect of a pro-erectile dose of apomorphine, a mixed dopamine receptor agonist, injected into the PVN on the release of dopamine by mesolimbic dopaminergic neurons in the “shell” of the nucleus accumbens; 2) the effect of oxytocin injected into the VTA on penile erection and on …
-
Interactions of the Striatal Gene Rhes with the Dopaminergic System in Rodents
… motor stereotypy, the mixed D1/D2 agonist apomorphine elicited a significant greater response in male KO and Het compared to WTs (p<0.05). In previous studies of D1/D2 synergism, it has been consistently found in rats and mice that when D2 receptors alone are stimulated, there is an early …
-
Central Alpha-Adrenoceptors and Behaviour
… inhibited motor activity alone, but potentiated apomorphine-induced activity in reserpinised mice. Antagonists with selectivity for α2 receptors, yohimbine and piperoxane, had behaviourally opposite effects to clonidine (although, like clonidine, these drugs again reduced activity) and in general …
-
An analysis of the role of midbrain dopamine systems in the suppression of tonic pain
… induced by a low autoreceptor-specific dose of apomorphine, prevents the analgesic effect of intra-VTA morphine. The findings revealed throughout the present thesis suggest that part of a pain-suppression system that serves to inhibit tonic pain depends, at least in part, upon the activation of …
-
The G protein-coupling specificity of D2-like dopamine receptors
… dopamine D2 receptor with the agonist ligand nor-apomorphine also allowed these conformation selective antibodies to bind the G protein. Such reagents allow the development of label- free assays for G protein-coupled receptor-mediated activation of Gi- family G proteins.
-
Characterization of the Roman lines/strains of rats as a genetic model of psychiatric disorders: a behavioral and brain dialysis study
… counterparts to both, the facilitatory effect of apomorphine and the inhibitory effect of haloperidol on sexual behavior. Finally, in study III we found that the isolation-rearing procedure significantly increased the level of anxiety of RHA-I rats in the EZM, as reflected by a smaller number of …
-
Synthesis and Evaluation of C-10 Nitrogenated Aporphine Alkaloids at Serotonin and Dopamine Receptors
<p>Aporphine alkaloids, belonging to the isoquinoline class of compounds, have been investigated as a potential source of ligands for Central Nervous System (CNS) receptors. Previous research indicates that the aporphine scaffold may be manipulated to synthesize selective ligands for serotonin and …
-
The Addicted Phenotype: Protein Phosphorylation Status and Dopamine Receptor Responsiveness
… experiment, responses to the mixed D1/D2 agonist apomorphine and the NMDA glutamate receptor antagonist MK-801 failed to differ between low and high intake rats. These findings suggest that cocaine addiction is specifically related to differential alterations in functional D1 and D2 receptors that …