Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 79 for “"Antipsychotics"”.
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Mechanism of Action of Antipsychotics, Haloperidol and Olanzapine in vitro
Schizophrenia affects 1-1.5% of people in the United States alone. Haloperidol (HP), a butyrophenone and a typical antipsychotic, has been used as an antipsychotic drug in human. Unfortunately, the therapeutic effects of HP also come with severe extrapyramidal side effects, resulting in movement …
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Non-Neuroleptic Antitubercular and Anticancer Therapeutics through Rational Drug Remodelling of Phenothiazines and Related Antipsychotics
… properties, phenothiazines and related antipsychotics elicit adverse side effects at clinically relevant doses thus precluding their extensive clinical application. Herein, it was postulated that the selectivity of phenothiazines and related drugs for nonneuroleptic indications could be …
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Investigation of the Effects of Antipsychotics on CNS Insulin-mediated Brain Glucose Uptake using 2DG Autoradiography
Antipsychotics (APs) drugs are associated with adverse metabolic side effect. Recent studies have shifted focus onto the central nervous system (CNS) suggesting that APs can induce central insulin resistance and disrupt glucose regulation. Attenuated central insulin action has also been shown to be …
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The Effect of Typical and Atypical Antipsychotics on the MK-801 Induced Deficit in Behavioural Inhibition
… sought to explore if typical and/or atypical antipsychotics have the ability to reverse deficits in behavioral inhibition (lack of extinction) seen following MK-801 administration. In addition, immunohistochemical labeling of pERK1/2 in the infralimbic cortex (IL) was examined after extinction …
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Identifying Barriers To Implementing Guidelines For Monitoring Metabolic Syndrome In Patients Prescribed Second-Generation Antipsychotics In Incarcerated Populations
… the evidence indicates that second-generation antipsychotics (SGAs, a conventional treatment) increase the risk of metabolic syndrome (MetS) often leading to weight gain, cardiovascular disease (CVD) and type 2 diabetes (DM 2). U. S. correctional institutions, faced with increased rates of …
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Identifying Barriers To Implementing Guidelines For Monitoring Metabolic Syndrome In Patients Prescribed Second-Generation Antipsychotics In Incarcerated Populations
… the evidence indicates that second-generation antipsychotics (SGAs, a conventional treatment) increase the risk of metabolic syndrome (MetS) often leading to weight gain, cardiovascular disease (CVD) and type 2 diabetes (DM 2). U. S. correctional institutions, faced with increased rates of …
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Prevalence of Anti-diabetic and Antilipidemic Medications in Children and Adolescents treated with Atypical Antipsychotics in a Virginia Medicaid Population
… use among children treated with atypical antipsychotics is higher than those not treated with antipsychotics. Methods: Virginia Medicaid beneficiaries (2-17 years) continuously enrolled from August 1, 2010 to July 31, 2011 with at least two prescription claims for atypical antipsychotics …
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The Discriminative Stimulus Properties of the Atypical Antipsychotic Clozapine in C57BL/6 Mice
… drugs. Previous data show that the atypical antipsychotics olanzapine, risperidone, ziprasidone but not the typical antipsychotic haloperidol fully substitutes for clozapine. The present study demonstrated that the atypical antipsychotics quetiapine, sertindole, zotepine, iloperidone, …
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Enhanced striatal glutamatergic function upon chronic antipsychotic action
… impaired executive function. Currently available antipsychotics mitigate some symptoms of schizophrenia, particularly the positive symptoms, but there is no preventive treatment nor cure after schizophrenia develops. Efforts to generate more effective antipsychotics are made particularly …
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Antipsychotic prescribing as a treatment of dementia in British Columbia: physician-level characteristics associated with receiving potentially inappropriate prescriptions
… attribute of this is off-label prescribing of antipsychotics to people with dementia to treat behavioural and psychological symptoms, which is not supported by evidence-informed guidelines. This manuscript investigated physician-level factors associated with prescribing antipsychotics to …
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Management of Treatment-Resistant Schizophrenia
… can be subdivided into typical and atypical antipsychotics, or first and second-generation antipsychotics respectively. In the case of treatment resistance to the initial antipsychotic trial, there a several approaches to treat patients with treatment-resistant schizophrenia. Some of these …
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A State-Level Analysis of Deinstitutionalization and the Impact of Chlorpromazine
… of major proportion. The introduction of antipsychotics in 1954 has often been considered instrumental in this population movement. To date, studies of the role of antipsychotics in deinstitutionalization have been state specific, methodologically weak, inconsistent in their findings and …
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Optimizing Antipsychotic Use across Nursing Homes: Implications for Dementia Care
… contextual factors associated with initiation of antipsychotics among short-stay nursing home residents with dementia; (2) evaluate the relationship of nursing home level initiation of antipsychotics with all-cause hospitalization and mortality; and (3) examine individual and contextual factors …
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The gut microbiota as a contributing factor to antipsychotic-induced weight gain and metabolic dysfunction
… their therapeutic value. Newer, atypical, antipsychotics are associated with a compilation of serious metabolic side effects including weight gain, insulin resistance, fat deposition, glucose dysregulation and ensuing co-morbidities such as type II diabetes mellitus. The mechanisms …
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Psichikos sutrikimų tyrimas ir jų gydymo įvertinimas klausos sukelto potencialo P300 metodu /
… work was to evaluate the influence of atypical antipsychotics risperidone and quetiapine and such nonpharmacological methods as electroconvulsive therapy and metaglossotherapy on the changes of information processing in the auditory system using event-related potential P300 recording and …
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Testing the efficacy of LSN2463359, a metabotropic glutamate 5 receptor positive allosteric modulator, in animal models of schizophrenia
… in a tonic manner. Therefore, while traditional antipsychotics directly block dopamine receptors, some of the newly generated compounds are designed to modulate glutamate to normal levels.</p> <p><strong></strong>I propose testing the efficacy of the metabotropic glutamate 5 receptor modulator …
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Estudo comparativo entre antipsicóticos atípicos no tratamento da esquizofrenia e sua influência na qualidade de vida dos pacientes
… treatment is done with typical and atypical antipsychotics. Atypical have the advantage of reduced extrapyramidal effects, which make them promising for the treatment of schizophrenia, furthermore, they have shown significant metabolic and hormonal changes. The objective of this study was to …
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Investigation of potential biomarkers of treatment-resistant schizophrenia
… treatment for people with TRS where other antipsychotics have failed. Yet its use is limited by potentially fatal side effects and there is still a subset, approximately 50- 70% of patients treated with clozapine, who do not experience clinically significant improvements in their symptoms, …
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