Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 157 for “"Antigen presentation"”.
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Structural Mechanism of Orthopoxvirus Sabotage of MHCI Antigen Presentation
… major histocompatibility complex class I: MHCI) antigen presentation can help viruses to evade cytotoxic T-lymphocyte: CTL) detection and clearance. Cowpox virus, like other orthopoxvirus family members, is a large DNA virus, whose genomic termini encode numerous immunomodulatory genes, including …
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VIRAL MODULATION OF MHC CLASS II-MEDIATED ANTIGEN PRESENTATION
… properties. Among these, VV infection of antigen presentation cells (APC) perturbs MHC class II-mediated antigen (Ag) presentation. The goals of this project include: 1) to define mechanisms by which VV disrupts class II presentation; and 2) to examine whether disruption of the class II …
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Developing a novel hepatitis B core – based antigen presentation system
… demonstrated that a tandem fusion of the core antigen (HBcAg) of hepatitis B virus (HBV) could direct the formation of core-like particles (CLPs) in plants. The work presented here demonstrated that the tandem core system is better suited for the plant-based production of CLPs presenting …
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Investigating the molecular mechanisms of chaperones involved in antigen presentation
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2024-08-01
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Antigen presentation: Influence of Cell Type and Route of Antigen Uptake
… and CD8-DCIR2+ conventional DCs. To examine antigen processing and presentation in vivo, antigens were specifically targeted to CD8+ and CD8- DCs using chimeric monoclonal antibodies. We find that CD8- DCs are better than CD8- DCs for presentation of exogenous antigens onto major …
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THE FUNCTIONAL REGULATION OF FCRN EXPRESSION AND FCRN-MEDIATED ANTIGEN PRESENTATION
… (MФ) and dendritic cells (DCs) can mediate antigen presentation in both MHC class II and MHC class I pathways. We tested here the role for FcRn in antigen presentation of IgG-restricted Immune complexes (ICs). It was observed that the expression of FcRn in MФ, but not in DC enhanced the …
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C-Jun N-Terminal Kinases Regulate Adenovirus-Mediated Autophagy and Antigen Presentation
… strategies. Importantly, autophagy promotes the presentation of self and foreign antigens for activation of immune cells. Our data demonstrated for the first time that adenoviral epitopes were presented at the surface of cells through JNK- and autophagy-dependent mechanisms. Rapamycin, a chemical …
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The role of tapasin and its isoforms in antigen presentation and tumor immunity
… (“isoform 1”) plays a critical role in MHC-I antigen presentation by facilitating peptide loading onto MHC-I molecules in the endoplasmic reticulum (ER). This thesis examines the expression, localization and function of two novel, alternatively-spliced isoforms of human tapasin that lack exon …
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Contribution Of Non-Classical Antigen Presentation To Cd4+ T Cells During Orthopoxvirus Infection
… interaction between the T cell receptor and an antigenic peptide in complex with an MHCII molecule on an antigen presenting cell. However, the primary means by which these peptides are generated and loaded onto MHCII molecules is debated. Historically antigen presenting cells have been thought …
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Variations in Antigen Presentation Define Regulatory T Cell formation and Activity in Vivo
… by variations in the amount of a cognate antigen (Ag) that is present, the cell types by which it is expressed and/or presented, and whether Ag recognition occurs in an inflammatory environment. Recognition of a weakly immunostimulatory self-peptide was able to promote both thymic …
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The Effects of Four Consecutive Days of Acute Exercise on Macrophage Antigen Presentation
… exercise on the ability of M&phis;'s to present antigen to T cells. Pathogen-free male Balb/c mice (8 +/- 2 wk) were randomly assigned to either home cage control (HCC), moderate exercise (MOD, 18 m min-1, 5% grade, 0.5 hr day1), exhaustive exercise (EXH, 18--30 m min-1, 3 hr day), or treadmill …
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Influence of the potency of antigen presentation on CD8+ T cell differentiation and memory
… killed targets and proliferated in response to antigen. Furthermore, inflammatory cytokines and T cells curtail antigen-presentation during BCG infection which curbs T cell stimulation and favors the development of functional memory.
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Protective immunity against Nippostrongylus brasiliensis requires antigen presentation by IL-4Rα responsive B cells
Nippostrongylus brasiliensis is a parasitic nematode infection that affects rodents. B-cells have been shown to play an important role in immunity to many different infections by antibody production and T-cell activation. But B-cell function in the protective TH2 response against N. brasiliensis …
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Expression Profiles of Molecules Involved in Antigen Presentation in Gangliosides-stimulated Primary Astrocytes from Rat brain
Astrocytes can function as antigen-presenting cells (APC) by expressing class II major histocompatibility complex (MHC) antigens and co-stimulatory molecules upon activation. In vitro, astrocytes are activated by lipopolysaccharides (LPS), and interferon-gamma (IFN-gamma). We previously reported …
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Employing T Cells For Antigen Presentation: Role of Ny-Eso-1+ T-Apc Vaccine In Multiple Myeloma
… of the NY-ESO-1 gene into T cells to make T cell antigen presenting cells (T-APC). Costimulatory molecules were added to the T-APC to help improve immunization efficacy. <em>In vitro</em> studies were conducted to evaluate the ability of T-APC to expand antigen specific effector cells compared to …
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Peptide Vaccine Formulation Controls The Duration of Antigen Presentation and Magnitude of Tumor‐Specific Cd8+ T Cell Response
… We previously showed that the duration of antigen presentation critically affected the quantity and quality of T cell response and subsequent anti‐tumor efficacy. Here we describe L‐tyrosine amino acid‐based microparticles as a novel peptide vaccine adjuvant for the induction of …
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Creating a New Malaria Vaccine Design that uses a Blood Stage P. falciparum Chassis for Non-Blood Stage Antigen Presentation
… to present infection and transmission stage antigens. Plasmids using the conditional translation repressor system TetR-DOZI were created, and transgenic parasites that express the scaffold protein eTRAMP4 fused to either CSP or P25 were generated. We assessed the transgenic parasites for …
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Studies of Non-Classical Antigen Presentation Molecules: Functional Analysis of Mouse Qa-1 and Characterization of the Porcine CD1 Gene Family
… appear to have a specialized antign (Ag) presentation role in given species. Two MHC class I-b molecules were studied, mouse Qa-1 and porcine CD1. First, Qa-1 expression was examined in pancreatic $\beta$-cells. The demonstration of interferon-$\gamma$-regulated Qa-1$\rm\sp{b}$ expression …
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The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production.
… for CD23 on B2 cells. When IgE is bound to its antigen to form an immune complex, IC, it binds CD23 and is internalized. After CD23 bound to IgE ICs is internalized, it is sorted into bexosomes. These bexosomes are transferred to dendritic cells which are responsible for presenting to T cells …
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