Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 77 for “"Antifungal Activity"”.
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The Influence of Biofilm on the Antifungal Activity of Amine Oxide
… DRS are known to the profession. Prescription antifungal creams alone or in combination with tissue conditioning are tried-and-true methods of treating DRS, however, effective <em>preventive</em> interventions are not readily available. If found, preventive therapy initiated before the onset of …
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ANTIFUNGAL ACTIVITY OF NATURAL AND NATURAL-INSPIRED BIOACTIVE COMPOUNDS TO CONTROL THE RICE BLAST FUNGUS
… exhibited the highest inhibitory activity on mycelial growth (60–80%), demonstrating potential as an environmentally friendly antifungal agent. Stilbene derivatives merged with strobilurin pharmacophores showed activity comparable to commercial fungicides, though their low efficacy …
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Synthesis, Characterisation and Antifungal Activity of Copper(II)-Functionalised Silicone Polymers and Silicone-Coated Magnetic Nanoparticles
Two families of amine-functionalised silicone polymers were prepared using monomeric (3-aminopropyl)triethoxysilane (APTES) and (3-trimethoxysilylpropyl)diethylene triamine (TMSPDT). Schiff base derivatives of these polymers were synthesised using salicylaldehyde. The same suite of polymers were …
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Substrate Utilization of the Emerging Fungal Pathogen, Candida auris, and the Antifungal Activity of Select Essential Oils
… resistant, sometimes to all three classes of antifungal drugs used to treat <em>Candida </em>infections. The objectives of this study are three-fold. First, two existing methods, population estimation using absorbance-based standard curves and methylene blue viability staining, were …
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Antimicrobial activity of human seminal plasma and seminal plasma proteins
… were responsible for the major bactericidal activity of seminal plasma. The activity of these peptides was strictly zinc-dependent. We also found potent antifungal activity in seminal unleashed by the acid vaginal pH. The antifungal activity was mediated by beta-microseminoprotein (MSP). The …
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Solution and solid-state NMR studies of amphotericin B
… index of AmB. The leading model for AmB antifungal activity is self assembly of the natural product into discrete, membrane-embedded barrel-stave pores which disrupt cellular ion gradients and cause cell death. A ring of salt bridges and/or hydrogen bonds at the channel periphery are …
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Electronic tuning of site selectivity and semisynthesis of C2'-deoxyamphotericin B
… spectrum of fungi, and resistance to this potent antifungal agent is rare. However, the use of AmB is limited due to its high toxicity. All of the details of the mechanism of AmB have not yet been elucidated, and a molecular understanding of the mechanisms and interactions of AmB would be an asset …
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Developing novel drug combinations for treatment of invasive fungal infections
… infections are restricted to three classes of antifungals: Azoles, polyenes, and echinocandins. The emergence of new fungal species, especially C. auris, marked by high resistance profiles and increased mortality rates (30-60%), has further exacerbated the limitations in its therapeutic …
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Synthesis and function of the conserved motif of mycosamine-containing polyene macrolides
… a large family of natural products with antifungal activity, of which amphotericin B (AmB) is an important member. Several of these clinically vital but toxic agents have been proposed to exert their biological activity through ion channel formation and thus represent small molecules with …
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Modified Farnesyl Diphosphate, Germacrane, and Eremophilane Sesquiterpenes as Probes for Capsidiol *Biosynthesis
… In addition, this library was evaluated for antifungal activity in order to establish preliminary structure-activity relationships.
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Targeting final steps of sugar nucleotide biosynthetic pathway against <i>Aspergillus fumigatus</i>
… azoles, echinocandins) are available for antifungal treatment with multiple issues including drug resistance, toxicity and undesirable drug-drug interactions. In recent decades, pharmaceutical companies have carried out research for novel antifungal agents with modest progression, which is …
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Investigação da atividade antifúngica do alfa-pineno sobre cepas de Rhizopus oryzea.
… aim of this study was to investigate the antifungal activity of promising fitoconstituinte, the α-pinene. For this, we determined the minimum inhibitory concentration (MIC), which was used strains of Rhizopus oryzae, belong to the Mycology Laboratory, Federal University of Paraíba (UFPB). …
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Etude de l'activité antifongique des bactéries lactiques isolées de produits alimentaires fermentés et caractérisation de leurs métabolites inhibiteurs
… aim of this present research was to study the antifungal properties of lactic acid bacteria (LAB) isolated from fermented Mill flour and fermented cassava in order to use them for biopreservation. Antifungal activity of these LAB were assessed in MRS solid medium against food spoilage moulds as …
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Screening and evaluation of bacteria for the biological control of Botrytis cinerea on Vitis vinifera
… This study aimed to test bacterial isolates for antifungal activity against B. cinerea and investigate their modes of action, which can aid in preventing grey mould in grapes. The dual-culture assay was used as a preliminary screening method to test antifungal activity against three B. cinerea …
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Isolation, Structure Elucidation and Biological Evaluation of Natural Products From Plants and Fungi
… with three Colletotrichum species to detect antifungal metabolites. Three crude extracts that shosignificant antifungal activity were selected for further bioassay-guided isolation. Various chromatographic techniques including preparative thin layer chromatography, vacuum liquid …
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Avaliação da atividade antifúngica de fitoconstituintes contra candida albicans
… so that, the necessity to develop new drugs with antifungal potential is also r ising, for example phytochemicals and other products from the environment. Therefore, the goal of this project was to analyse the antifungal activity of the phytochemical components citral and geraniol on strains of …
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Applications of the achmatowicz rearrangement in natural product synthesis
… DNA and RNA synthesis and have potent cytotoxic activity in vivo. The Ajudazols A and B were isolated in 2004 and have antifungal activity against several important food spoilers. The work that follows details the design and development of a novel method for the generation of the isocoumarin core …
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Synthesis and Antifungal Evaluation of Spirostane Saponins
<p> <p>Methods for the preparation of novel antifungal saponins have been investigated in</p> <p>order to further explore their medicinal utility and provide the opportunity to synthesize</p> <p>their derivatives.</p> <p>Through this work, several partially protected stereoisomers of …
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Nanocápsulas furtivas de óleo de copaíba contendo anfotericina B: um sistema promissor no tratamento de infecções fúngicas sistêmicas
… modeling was carried out to verify a possible antifungal activity from copaiba oil compounds and fungal proteins. A strong interaction between the compounds and the Δ-14-sterol protein site indicating antifungal activity through inhibition of ergosterol synthesis. Two systems were developed: …
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Elucidation of the mycosamine dependent sterol binding and antifungal activities of amphotericin B
… B (AmB) is a clinically vital, yet highly toxic antifungal agent that is dependent on the presence of membrane sterols to exert its biological activity. This natural product has been shown to form ion channels in model membrane systems and therefore represents a molecule with the capacity to …
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