Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Antibacterials"”.
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Investigation into the antimicrobial activity of cationic antibacterials.
The topic addressed by the 2011 WHOs World Health Day was antibacterial resistance. This action served to highlight the serious problem bacterial resistance now presents to healthcare professionals globally. This investigation focussed on the action of four cationic antimicrobial agents against E. …
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Physicochemical trends of compound efflux in gram-negative bacteria and characterization of novel antibacterials
Submission published under a 24 month embargo labeled 'Closed Access', the embargo will last until 2026-08-01
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PART I: SYNTHESIS OF PHENOLIC ANTIBACTERIALS AND NATURAL PRODUCTS PART II: RAPID ASSESSMENT OF HYDROGEN BONDING CAPACITY
… less environmentally durable than biaryl ether antibacterials such as the broadly used triclosan were found to be active. MRSA mutants could be generated against some, but not all, of the highly active compounds. Gene sequencing results, membrane permeability, intracellular sodium, and …
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Investigation of ciprofloxacin antibacterial combinations.
… future success of the fluoroquinolone class of antibacterials. Therefore, the present study was undertaken to determine whether combining ciprofloxacin with trimethoprim and or a sulphonamide could prove clinically beneficial. The microbiological activity of the antibacterials used either alone …
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Expanding Access to Novel Antibacterial Therapeutics in Low- and Middle-Income Countries: Leveraging Donor-Funded Pooled Procurement
… bacteria continue to evolve faster than new antibacterials are being developed. In 2019, 1.27 million deaths were directly attributable to bacterial antimicrobial resistance (AMR) globally—more than either HIV or malaria that year—with the highest death rates occurring in low- and …
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Regulation of the Tubulin Homolog FtsZ in <i>Escherichia coli</i>
… may be potential targets for development of antibacterials or bacteriostatics, which are much needed for fighting the current global antibacterial deficit. My thesis work focuses on understanding how <em>E. coli</em> cell division is regulated.</p>
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Investigating pathogen 4Fe-4S protein targets and cancer chemotherapies with bisphosphonate/diphosphate inhibitors
… in human cancers. For the development of antibacterials and antiparasitics, this research investigates the structure, function, and inhibition of the essential penultimate and ultimate enzymes of the MEP pathway, IspG (iron sulfur protein G; also known as GcpE and …
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Investigation of phosphonate biosynthesis: I. Structure of dehydrophos II. Mechanism of hydroxyethylphosphonate dioxygenase
… are used extensively in the clinic as antibacterials and in commercial agriculture as herbicides. In an effort to efficiently discover new natural product phosphonates, a multidisciplinary, collaborative program has been established at the Institute for Genomic Biology at the University …
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Topical pharmacokinetics for a rational and effective topical drug development process
… vitamin D3 derivatives, antifungals, antibacterials for acne and immunomodulators. For seven out of the eight classes, the validation of the model is good. For the last class, the antibacterials for acne, the model underpredicts efficacy and it is suggested that the route of entry of …
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PTEN-5-HT2CR Complex: An Ideal Target for Developing Treatment to Restore the Functioning of 5-HT2CR; An Attempt to Minimize the Development of Antimicrobial Resistance
… of aminoacylation reaction are ideal targets for antibacterials. AN2690, a benzoxaborole derivative, shows great antibiotic activity by trapping tRNALeu in the editing domain. Inspired by AN2690 and other benzoxaborole derivatives, we designed …
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Discovery and Characterization of an Antibacterial Metabolite, Produced by a Death Valley Soil Microbe, Active Against Gram-Negative Bacteria
… antibacterial compounds, with 55% of approved antibacterials from 1981 to 2019 derived or inspired by NPs. NPs continue to serve as major sources of novel bioactive compounds and scaffolds with substantial unexplored biosynthetic diversity remaining in nature. Soil samples collected from …
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A systematic review of treatments for atopic dermatitis
… antibiotics on clinically uninfected AD, topical antibacterials, topical antifungals, aromatherapy essential oils, borage oil, fish oil, evening primrose oil, enzyme-free clothes detergent, cotton clothing, house dust mite hyposensitisation, salt baths, topical coal tar, topical cyclosporin and …
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Actividad antibacteriana de extractos vegetales en cepas hospitalarias de "Staphylococcus aureus" con resistencia múltiple
… compounds have a potential application as antibacterials for what is suggested to measure their pharmaceutical properties to establish their use as a therapeutic agents.
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Analysis of Small Molecule Inhibitors Aimed at Bacterial Virulence
… have motivated the development of novel antibacterials. One recently proposed strategy is to target pathogenic bacteria specifically by inhibiting virulence mechanisms as opposed to killing bacteria indiscriminately, which includes commensal strains. Due to the increased appreciation for …
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Pathway engineering for the discovery and optimized production of phosphonic acids
… century, a period known as the Golden Age of Antibacterials, the natural product field experienced a wave of discovery that has yet to be replicated. Even with the increased focus on using synthetic chemistry to discover potential pharmaceuticals, there has been a steady decline in discovery …
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Studies on the stability and activity of polymyxin B solutions.
… The effect of preservatives and of second antibacterials contained in the eye drops were tested individually and combined with polymyxin B. Thiomersal 0.001 %w/v, trimethoprim 0.02 %w/v and thiomersal 0.001 %w/v plus trimethoprim 0.02 %w/v did not have an effect on the activity of polymyxin …
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Synthesis and translation of novel gram-negative antibacterial agents
Pathogenic bacteria have been, and always will be, a scourge to mankind. Efforts to develop new drugs have been traditionally stymied by a lack of understanding about what properties are correlated with enhanced permeation into bacteria, with gram-negatives especially being a problem due to their …
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The relevance of bacteriophage therapy in the era of antibiotic resistant bacteria
… at developing and administering these powerful antibacterials. However, it is now obvious that the old paradigm of depending on a constant stream of novel antibiotics is no longer valid and alternative technologies such as this must be fully explored.
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Investigation of the effects of antifolates on Escherichia coli 1810.
… approaching the respective MICs of the antibacterials, then this effect on cell structure was concluded to be a normal component of their antibacterial action. OM-PG associated protein bands separated from both E.coli strains by SDS-PAGE after exposure to either 1/2 MICs of SD or TMP …
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Novel small molecules for modulation of bacterial signaling pathways
Conventional treatments for bacterial infections target bacterial viability, an approach that exerts a strong selective survival pressure on bacteria, leading to the development of multidrug resistant mutants. The number of multidrug resistant strains is increasing exponentially, far outpacing the …
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