Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 633 for “"Akt"”.
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Gsk3 Mediates Signaling Upstream of Akt
The phosphatidylinositide 3 kinase (PI3K)/Akt signaling network plays a pivotal role in multiple cellular functions. PI3K links the extracellular growth factor receptors to the serine-threonine kinase Akt which, through phosphorylation of numerous intracellular proteins, mediates increased cell …
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Integrin α2 and Akt in early hematopoiesis
… we demonstrated that hyperactivation of Akt, which is a key intrinsic factor regulating the homeostasis of HSCs, was incompatible with the survival and growth promoting ability of FMS-like tyrosine kinase 3-internal tandem duplication (FLT3-ITD) signaling in murine stem and progenitor …
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Modulation of Pi3K-Akt Pathway In Colorectal Cancer
… (<em>PIK3CA</em><sup>mut</sup>). Allosteric AKT inhibition with MK2206 monotherapy has been ineffective in CRC patients. We investigated the impact of MK2206 on pharmacodynamic (PD) markers and signaling pathways using reverse phase protein array (RPPA) on (1) paired tumor biopsies from a …
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Regulation of Akt ignal transduction by glucose metabolism
… relies on activation of the Ser/Thr kinase Akt, I examined the effects of 3PO on Akt signaling and found that insulin-dependent phosphorylation of Akt, an index of its activation, was inhibited by 3PO in 3T3-L1 adipocytes. I next examined the consequences of heterologous overexpression of …
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Genetic Analysis of the PI3K/AKT/mTOR Signaling Pathway
… to dysfunctional cell signaling. The PI3K/AKT/mTOR pathway is an important pro-growth intracellular signaling cascade that is often inappropriately activated in a wide array of cancers. Efforts to develop anticancer drugs have therefore focused, in part, on identifying PI3K/AKT/mTOR pathway …
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Συστηματική ανασκόπηση: Ο ρόλος των AKT αναστολέων στον μεταστατικό καρκίνο του μαστού / Role of AKT inhibitors in metastatic breast cancer: A systematic review
… Η απορρύθμιση του μονοπατιού σηματοδότησης PI3K/AKT/mTOR αποτελεί συχνό μοριακό γεγονός στον καρκίνο του μαστού και έχει συσχετιστεί με την εξέλιξη της νόσου και την ανάπτυξη θεραπευτικής αντίστασης. Σκοπός της παρούσας συστηματικής ανασκόπησης ήταν η αξιολόγηση της αποτελεσματικότητας και της …
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PKB/Akt : a critical regulator of lymphocyte, development and function
Protein kinase B (PKB), a serine threonine kinase, is highly involved in the regulation of cellular proliferation and survival. To characterize PKB’s function in lymphocyte development and activation, transgenic (tg) mice that express a membrane targeted constitutively active form of PKBa (myr PKB) …
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Glycogen Synthase Kinase 3 Is Required For Optimal Akt Activation
… (PI3K) pathway, through its major effector node AKT, is critical for the promotion of cell growth, division, motility and apoptosis evasion. This signaling axis is therefore commonly targeted in the form of mutations and amplifications in a myriad of malignancies. Glycogen synthase kinase 3 …
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Redox Regulation of Akt Phosphorylation in PTEN-/- Mouse Embryonic Fibroblasts
… role of O2.- in regulating the survival kinase Akt via an oxidative inhibition of PTEN by S-nitrosylation. During the course of this study, it was noticed that in mouse embryonic fibroblasts that do not express the tumour suppressor PTEN (MEFPTEN-/- cells), a decrease in the intracellular level …
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Evaluation of the PI3K/Akt/mTOR pathway in Multiple Sclerosis
Background The PI3K/AKT/mTOR pathway is an intracellular signaling pathway that regulates cell activation. proliferation, metabolism and apoptosis. Increasing body of data suggests that alterations in the PI3K/AKT/mTOR pathway may result in an enhanced susceptibility to autoimmunity. Aim of our …
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The Role of K63-Linked Ubiquitination Cycles In Akt Kinase Activation
<p>Akt (also known as protein kinase B) serves a central regulator in PI3K/Akt signaling pathways to regulate numerous physiological functions including cell proliferation, survival and metabolism. Akt activation requires the binding of Akt to phospholipid PIP3 on the plasma membrane and subsequent …
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Nephrin und CD2AP aktivieren den PI3-Kinase/AKT-Signalweg im Podozyten
… der PI3-Kinase, interagieren. <br>Die Interaktion von Nephrin und p85 ist Phospho-Tyrosin-abhängig und kann durch Genistein, das die Phosphorylierung des intrazellulären Nephrin-Abschnittes hemmt, aufgehoben werden. <br>Nephrin und CD2AP induzieren Phosphorylierung und Aktivierung der …
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DNA Damage-dependent Regulation and Function of akt-1 in Caenorhabditis elegans
… This pathway ultimately controls the action of Akt homologues on the forkhead transcription factor DAF-16. The C. elegans Akt orthologue akt-1 also negatively regulates the DNA damage-dependent apoptosis of worm germ cells by indirectly interfering with activation of the key transcription factor …
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The Role of CDCA7 in Akt-mediated Myc-Dependent Apoptosis and Proliferation
… by the prosurvival serine/threonine kinase Akt. Phosphorylation by Akt at threonine 163 disrupts CDCA7 association with Myc, promotes binding to 14-3-3 and sequestration in the cytoplasm. Coexpression of CDCA7 and Myc in fibroblasts potentiates Myc-dependent apoptosis upon serum withdrawal. …
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PREPARATION AND EVALUATION OF DECONSTRUCTION ANALOGS OF 7-DEOXYKALAFUNGIN AS AKT INHIBITORS
… inhibitors of the serine-threonine kinase AKT/PKB. AKT/PKB plays a major role in tumorigenesis, hence these compounds have a great potential to act as anti-cancer agents. They act by a novel bioreductive alkylation mechanism of inhibition of AKT/PKB. In this work, 7-deoxykalafungin, a …
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PI3K/Akt activation is critical for early hepatic regeneration after partial hepatectomy
… accumulation. My data demonstrate that PI3K/Akt pathway activation plays a critical role in the early regenerative response of the liver after resection; inhibition of this pathway markedly abrogates the normal hepatic regenerative response, perhaps by inhibiting macrophage infiltration and …
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Small Molecule Regulator of ENTPD5, and ER Enzyme in the PTEN/AKT Pathway
… effector of PI3K is the serine-threonine kinase Akt, which in response to PI3K activation, phosphorylates and regulates the activity of a number of cellular targets, through which it modulates a variety of cellular functions, including glucose metabolism, protein synthesis, cell proliferation and …
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Gastrin-releasing peptide-mediated neuroblastoma growth: A role for the PI3K/Akt pathway
… of the phosphatidylinositol-3-kinase (PI3K)/Akt pathway, a crucial regulator of cell survival, is associated with poor outcome in neuroblastomas and our lab¡¦s previous work has shown that GRPR regulates the expression of PI3K/Akt pathway components. However, the signaling mechanisms involved …
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