Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 10 of 10 for “"Aggregation and Deposition"”.
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Insights into asphaltene stability, aggregation, deposition and molecular structure
Asphaltenes are the heaviest, most polar, and most surface-active species of crude oils which are fairly stable in the oil; however, a small variation in the pressure, composition, and temperature can cause asphaltene phase instability and alteration in their solubility parameter and can …
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Endocytic Trafficking of The Amyloid Precursor Protein In Rat Cortical Neurons
<p>Amyloid-beta (Aβ) aggregation and deposition into extracellular plaques is a hallmark of the most common forms of dementia, including Alzheimer’s disease. The Aβ-containing plaques result from pathogenic cleavage of amyloid precursor protein (APP) by secretases resulting in intracellular …
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The effects of perinatal choline supplementation on neuroinflammation in the plaque niche of APP-NL-G-F mice
… disease commonly characterized by the aggregation and deposition of insoluble amyloid beta plaques throughout the brain, and by an associated neuroinflammatory response to these plaques involving astrocytes and microglia. Choline is an essential nutrient with diverse functional roles …
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Molecular Modeling of the Amyloid β-Peptide: Understanding the Mechanism of Alzheimer's Disease and the Potential for Therapeutic Intervention
… leading cause of senile dementia in the elderly, and as life expectancy increases across the globe, incidence of the disease is continually increasing. Current estimates place the number of cases at 25-30 million worldwide, with more than 5.4 million of these occurring in the United States. While …
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The Role of Metal Ions and Reactive Oxygen Species in beta-Amyloid Aggregation and Toxicity and Their Relevance to Alzheimer's Disease.
The aggregation and deposition of beta-amyloid (AB) in the brain has long been implicated in the neurotoxic pathways causing Alzheimer's disease (AD). Recent data suggests that early, soluble oligomers of Ap are the toxic species. Oxidative stress may be partly responsible for the toxicity of the …
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New Insights Regarding the Intracellular Effects, Trafficking, and Quality Control of the Amyloid Precursor Protein: Implications for Alzheimer’s Disease Pathogenesis
… form of age-related dementia. Our current understanding of AD pathogenesis is largely based on data from cases of relatively rare early-onset forms of the disease, collectively known as familial AD (FAD). FAD is associated with discrete mutations in three genes: PSEN1 and PSEN2, which encode the …
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Structural Elucidation of the Interaction Between Neurodegenerative Disease-Related Tau Protein with Model Lipid Membranes
… folded structure is linked to protein function, and misfolding to dysfunction. Protein misfolding and aggregation into β-sheet rich fibrillar aggregates is connected with over 20 neurodegenerative diseases, including Alzheimer's disease (AD). AD is characterized in part by misfolding, aggregation …
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An investigation into the effects of inorganic element status on the accumulation and deposition of amyloid in various diseases.
… to be associated with amyloidogenic peptides and proteins, for example, β amyloid (Αβ) in senile plaques of Alzheimer's disease and β2 microglobulin (β2M) deposition in dialysis related amyloidosis. The major factor for amyloidosis appears to be an increase in the production of amyloidogenic …
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Carbon Nanotube Behavior in Represntative Old Leachate
<p>Escalating production and subsequent incorporation of engineered nanomaterials in consumer products increases the likelihood of nanomaterials being discarded in municipal solid waste (MSW) landfills. Many commonly discarded products have been reported to contain nanomaterials, including …
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Engineering Superparamagnetic Iron Oxide Nanoparticles for Environmental Applications
… range of applications based on tunable size and shape, surface chemistries, and magnetic properties. For successful aqueous-based, environmental applications, it is necessary to overcome two, fundamental, yet interconnected challenges: 1) Design and synthesize material which provides …