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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 62 for “"Acridine"”.
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STRUCTURE-ACTIVITY RELATIONSHIPS IN FUNCTIONALIZED PLATINUM-ACRIDINE ANTICANCER AGENTS
Since Rosenberg's serendipitous discovery of the cytotoxic properties of cis-diamminedichlor(id)oplatinum(II), better known as cisplatin, the development of new platinum-based chemotherapies with improved activity and reduced toxicity has become a pressing goal. Many second- and third-generation …
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CHARACTERIZATION OF THE RNA BINDING MODE OF A PLATINUM-ACRIDINE AGENT
… platination and intercalation of the acridine chromophore. The RNA binding of platinum drugs has been studied to a much lesser extent. Recently, the RNA interactions of platinum-containing drugs and drug conjugates have been reported. In the current study, an RNA hairpin has been …
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NOVEL STRATEGIES FOR IMPROVING THE PHARMACOLOGICAL PROPERTIES OF PLATINUM-ACRIDINE ANTICANCER AGENTS
… platinum-based anticancer drugs, platinum-acridine hybrid agents were designed as dual platinating/intercalating DNA-targeted cytotoxics, which are able to cause cancer cell death at low-nanomolar concentrations. Unfortunately, the preclinical development of these agents has been hampered …
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PREPARATION AND EVALUATION OF MESOPOROUS SILICA NANOPARTICLES FOR PLATINUM-ACRIDINE ANTICANCER DRUG DELIVERY
… delivery platform for highly cytotoxic platinum-acridine anticancer agents. The first part of the thesis introduces new methodology for increasing the pore size of MSNs in a controlled manner. It was found that, in the presence of n-decane as a swelling agent and DMF as a co-solvent, large-pore …
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An evaluation of the theory and use of the acridine orange stain in enumerating bacterial populations
… pHs of aqueous solutions of the fluorochrome, acridine orange (AO). Results from this study gave strong supportive evidence for the non-vital staining properties of acridine orange contrary to previous reports in the literature. Green fluorescence of cells is not a reliable indicator of …
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Targeting HIV-1 RNAs with Medium Sized Branched Peptides Featuring Boron and Acridine-Branched Peptide Library Design, Synthesis, High-Throughput Screening and Validation
… unique sequences that featured boronic acid and acridine moieties was designed. We chose acridine as the amino acid side chain due to its potential for π-stacking interaction that provides high binding affinity to RNA target. The library was screened against HIV-1 RRE IIB RNA. Fifteen peptides …
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ADVANCES IN THE DIRECTED ORTHO METALATION, SUZUKI-MIYAURA CROSS COUPLING, AND RING-OPENING REACTIONS OF INDAZOLES. SYNTHESIS OF LUMINESCENT ACRIDINE AND NOVEL INDAZOLE-BASED OXAZABORINES
… advances in the synthesis of highly luminescent acridine and novel indazole-based boron(III) complexes are detailed herein. To the best of our knowledge, these are the first oxazaborines of indazole reported in the scope of the current literature.
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Enediynylacridans: design and synthesis of oxidase triggered diyl progenitors
… products. Oxidation of the acridan (dihydro acridine) to the acridine would induce base catalyzed propargyl-allenyl isomerization. This would serve as the triggering device which leads to Myers cyclization and thus the diradical. The acridine portion of the molecule would also serve as the …
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STRUCTURE–ACTIVITY RELATIONSHIP STUDIES OF HYBRID ANTITUMOR AGENTS FOR THE TREATMENT OF NON-SMALL CELL LUNG CANCER
… (en = ethane-1,2-diamine; ACRAMTU = 1-[2-(acridine-9-ylamino)ethyl]-1,3-dimethylthiourea) (PT-ACRAMTU, 31), is a dual platinating/intercalating DNA binder that, unlike clinical platinum agents, does not induce DNA cross-links. The research in this dissertation was concerned with …
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Single molecule studies of ligand-DNA interactions using atomic force microscopy
… of the binding of ligands that incorporate the acridine chromophore. These changes are distinct from those observed following the binding of other intercalators such as doxorubicin and echinomycin. Direct measurement of the length of linear DNA strands bound to acridine based ligands reveals a …
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RNA recognition: controlling RNA-protein complexes with small molecules
… small molecules containing triaminotriazine-acridine and triaminopyrimidine-acridine conjugates which can specifically inhibit (CUG)12 and (CCUG)6 complexes with MBN1N protein, respectively. Thus the compounds triaminotriazine-acridine and triaminopyrimidine-acridine conjugates are potential …
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Kelvin Probe Force Microscopy on Graphene Thin Films for Solar Cell and Biosensing Applications
… cost-effective, water-soluble, and bio-sensitive acridine orange molecules. We investigated the morphology and work function of acridine orange using Atomic Force Microscopy and KPFM. Acridine orange’s ability to generate sufficient amounts of photo carriers was also demonstrated using KPFM under …
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Exploring the potential of chloroquine and quinacrine derivatives as new antiprotozoal and tumour drug resistance reversal agents
Compounds containing the quinoline and acridine moieties have been utilized extensively in the search for new antiprotozoal and multidrug resistance reversal agents. Hence, these moieties formed the basis for the synthesis of new compounds. New sulfonamides, ureas and amine analogues were …
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Molecular tweezers: Synthetic receptors for the DNA base adenine
… efficient. A new methodology for 9-substituted acridines was developed to facilitate the syntheses of molecular tweezers containing acridine chromophores. A novel rearrangement in 9-arylacridines is described. An aryl-aryl coupling reaction was applied to form the molecular tweezers containing …
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Chemically bonded stationary phases using molecular tweezer hosts: A quantitative HPLC binding assay for nitro-aromatic guests
… prepared from the following synthetic hosts: bis-acridine, bis-phenanthrene, and bis-trimethoxyphenanthrene molecular tweezers 74, 89, and 92. The retention times of several $\pi$-electron deficient guests were measured as a function of temperature on HPLC columns made from each of these CBSPs. …
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A Study of the Coccoid Bodies of Prolinoboborus fasciculus (Aquaspirillum fasciculus)
… Although the coccoid form fluoresced with acridine orange, agarose gel electrophoresis revealed extensive ribosomal RNA degradation. Poly-Ã -hydroxybutyrate, abundant in the vegetative rods, was not detectable in the coccoid cells. The results suggest that the coccoid form of A. fasciculus …
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