Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 102 for “"ATR-FTIR"”.
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The use of ATR-FTIR to probe the release mechanism from hydrophilic matrices.
Hydrophilic matrices are widely used in the pharmaceutical industry as control release agents in solid oral dosage formulations. One of the key parameters that controls release in such systems is the distribution of exipients within the formulation, which in turn is governed by the processing and …
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ATR-FTIR Measurements of Cationic Surfactant Exchange Rates at the Solid-Liquid Interface
In many experiments, surfactant adsorption and desorption at solid-liquid interfaces is found to be quite slow, considering that surfactants are small molecules. Attenuated total reflectance Fourier transform infrared spectroscopy was used to study the adsorption, desorption, and exchange of …
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Investigation of membrane permeation using ATR-FTIR spectroscopic imaging and multivariate target factor analysis
Attenuated total reflectance Fourier transform (ATR-FTIR) spectroscopy and ATR-FTIR spectroscopic imaging was used for the in vitro monitoring of the mechanisms of drug permeation and the effects of penetration enhancers on silicone membrane and human stratum corneum (SC). Simulated spectroscopic …
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ATR-FTIR spectroscopy and Raman microscopy studies of organosilane diffusion and hydrolysis in PVC films.
… Fourier transform infrared spectroscopy (ATR-FTIR) and Raman confocal microscopy have been used to study the diffusion, hydrolysis and condensation of three organosilanes in silicon / PVC / silane laminates. These processes are thought to contribute to the formation of the IPN, and hence …
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Application of attenuated total reflection Fourier transform infrared (ATR-FTIR) spectroscopy to measure sub-lethal effects of potential mutagens
… total reflection Fourier transform infrared (ATR-FTIR) spectroscopy, was able to detect changes in various tissue samples exposed to varying levels of polycyclic aromatic hydrocarbons (PAHs). This technique discriminated between spatial and temporal variations in the interrogated tissues. …
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Analysis of Blue Fountain Pen Ink by UV-Vis Spectroscopy, ATR-FTIR Spectroscopy, and Thin Layer Chromatography Enhanced with RGB Spot Evaluation to Construct a Database for Comparison and Identification.
… RGB spot evaluation, UV-Vis spectroscopy, and ATR-FTIR spectroscopy. All three methods were used to analyze 89 fountain pen ink samples. All three methods were able to discriminate between the majority of the ink samples. However, some samples were still similar and difficult to differentiate …
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Exploring the Structure-Function Relationships and Dynamics of the Heme/copper Oxidase Superfamily Using Cytochrome Bo(3) From Escherichia Coli as a Model System
… oxidases by attenuated total reflectance (ATR) FTIR is presented, and preliminary results are shown, which demonstrate that cytochrome bo3 can be constituted into stable thin films, suitable for ATR-FTIR work.
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Investigating the effects of organic pollutants on amphibian populations in the UK
… total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy in conjunction with multivariate analysis was implemented in order to distinguish between embryos, whole tadpoles at an early stage of development and individual tissues of late-stage tadpoles of the common frog collected from …
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Rapid Screening Methods to Identify Substandard and Falsified Medicines
… Total Reflectance Fourier Transform Infrared (ATR FTIR). The mass spectrometer was the least reliable instrument, but provided the greatest sensitivity. Successful identification of the API was obtained from ATR FTIR and Raman analysis and from Direct Insertion Probe (DIP) Mass Spectrometry. …
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FORENSIC PHARMACEUTICAL ANALYSIS OF COUNTERFEIT MEDICINES
… Total Reflection-Fourier Transform Infrared (ATR-FTIR) spectroscopy, Raman spectroscopy and two probe Mass Spectrometry (MS) methods were assessed for the rapid screening of tablet dosage forms. These systems were chosen because NO solvent extraction of the sample was required. Comparison with …
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Vibrational spectroscopy as a tool to investigate the effects of environmental contaminants in predatory birds
… total reflection Fourier-transform infrared (ATR-FTIR) and Raman spectroscopy techniques with multivariate analysis. By analysing untreated predatory bird tissues, vibrational spectroscopy was shown to reveal fundamental, underlying biochemistry. The ability to generate tissue-specific …
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The physico-chemical and biological analysis of microbial biosurfactants (BSs) for applications towards cancer therapies, wound healing dressings and drug delivery
… (BS3) were investigated through LC-MS, ATR-FTIR and surface tension analysis. This was followed by examination of cytotoxic activities determined via MTT assay following cell line-specific optimisation at intervals of 24, 48 and 72 h treatment on non-cancerous human embryo kidney (HEK …
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Optimal Control of Antisolvent and Cooling Crystallization
… The first part of this thesis collected ATR-FTIR spectra and built a calibration model, whose regression coefficients were used along with ATR-FTIR spectra to measure the solubility of paracetamol in isopropanol-water solution at various temperatures and solvent ratios, also for further …
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Detection and quantification of sub-micromolar concentrations of aqueous anions using infrared spectroscopy and mass spectrometry
… total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy, were used for the detection and quantification of low concentrations of aqueous anions. Some of these anions, including perfluoroalkanesulfonates (PFAS–), perchlorate, phosphonates, and cyanide, are of interest given that …
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Diagnostic Neuropathology of Brain Tumours using Biophotonics and Spectrometry
… total reflection-fourier transform infrared (ATR-FTIR) looking at brain tumour cell lines. This study investigated the potential application of vibrational spectroscopy in the segregation of different types of brain tumours using two tumour cell lines, U87MG, 1321N1 and a control, SVGP12. …
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The use of hair detect (and monitor) chronic hyperglycaemia
… transform infrared- attenuated total reflection (ATR-FTIR) spectroscopy. Spectra were analysed using statistical software (SIMCA, Umetrics) to determine whether the hair of diabetics was distinguishable from hair of healthy controls as well as whether spectra correlated with HbA1c levels of …
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Analysis of the composition of latent fingermarks by spectroscopic imaging techniques.
… to investigate latent fingermarks, with SERS and ATR-FTIR used as complementary techniques.One of the major issues of using analytical techniques to investigate latent fingermarks is their inadequate application to real crime scene scenarios. Presented within this thesis is a new method of matrix …
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The rational design of dermatological formulations
… experiments were conducted using an established ATR-FTIR approach but the data interpreted using sophisticated chemometric approaches which allowed the deconvolution of the IR signals of all permeating species and the membrane. Using this approach it was possible to examine the individual …
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Design and development of an electrochemical and infrared spectroscopic medical device for serum-based cancer diagnostics
… 11 tested clinical patient samples.Additionally, ATR-FTIR discriminated between Hodgkin’s lymphoma and healthycontrols in 200 patient samples with sensitivity of 83.2 ± 6.6% and specificity of 85.3± 8.1% with Random Forest classification, highlighting differences in proteinsecondary structures …
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