Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1525 for “"ATP"”.
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Enzymatic regeneration of ATP,
Thesis (Sc. D.)--Massachusetts Institute of Technology, Dept. of Chemical Engineering, 1974.
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MOLECULAR REGULATION OF ATP-CITRATE LYASE
ATP-citrate lyase (ACLY) is the major source of glucose-derived acetyl-CoA outside the mitochondria and is an attractive therapeutic target for metabolic disorders and cancer. In the cytosol, acetyl-CoA is used for lipid synthesis and is also the essential substrate for protein acetylation. In the …
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Erzeugung und Analyse NF-ATp-defizienter Mäuse
… nachgewiesen. Bezüglich des manipulierten NF-ATp-Gens heterozygote F1-Tiere wurden miteinander verpaart, um eine homozygote NF-ATp-defiziente Mäuse zu erhalten. Die Deletion des NF-ATp-Proteins wurde durch in Western-Blotting-Experimenten und EMSAs ("electrophoretic mobility shift assays") …
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Membrane trafficking of ATP-sensitive potassium channels
ATP-sensitive potassium (KATp) channels are known to play a vital role in the regulation of insulin secretion from pancreatic 0-cells. Changes in the ratio of [ATP]/[ADP] within the cell are known to regulate the activity of channels, but very little is known how the number of channels at the cell …
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ATP, TRP channels and airway neuronal sensitisation
… gaining a deeper understanding of the roles of ATP and transient receptor potential (TRP) channels in chronic cough by working with primary bronchial epithelial cells (PBECS) and an in-Vitro human sensory neuronal model differentiated from human dental pulp stem cells termed peripheral neuronal …
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Inhibition of tau kinase activity by ATP
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 1998.
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Development of Non-Atp Competitive, Plk1-Selective Inhibitors
… using REPLACE, we believe we can develop a non-ATP competitive inhibitor that is not only PLK1 specific but is less toxic to normal cells and safer than current chemotherapeutics on the market.</p>
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Mitotic slippage by ATP depletion and its mechanism
… checkpoints monitoring the amount of available ATP during G1 phase and G2 to M transition. However, it is still uncertain the existence of energy checkpoint during mitotic progression. In our hand, ATP depletion by the co-treatment with 2-deoxy glucose (2-DG) and sodium azide (NaN3) during …
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Charakterisierung interagierender Proteine des renalen ATP-abhängigen Kaliumkanals ROMK
ROMK ist ein einwärts-gleichrichtender Kaliumkanal, der hauptsächlich in der Niere exprimiert wird. Er wird dabei vor allem in der apikalen Membran des aufsteigenden Astes der Henleschen Schleife, dem distalen Tubulus und dem Sammelrohr exprimiert. Die Hauptaufgaben von ROMK bestehen in der …
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DYNAMICS OF NUCLEOSOME REMODELING BY ATP-DEPENDENT CHROMATIN REMODELERS
… regulating the dynamic nature of chromatin are ATP-dependent chromatin remodelers- ISWI, SWI/SNF, INO80, and CHD/Mi2. All chromatin remodelers transduce the energy from ATP hydrolysis to translocate on DNA, break histone-DNA contacts, and mobilize nucleosomes. However, the final outcomes of …
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Comparative Studies of Processivity Clamp Loader ATP Site Function
… clamps to ensure polymerase processivity. An ATP-dependent clamp loader topologically links the clamp around DNA in a multi-step mechanism. Clamp loaders are ring-shaped pentamers of AAA+ subunits. The pentamer complex contains 3-4 ATP sites, each located at the interface of two subunits. In …
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Die Wirkung von Antikonvulsiva auf ATP-sensitive Kalium-Kanäle
… Gabapen-tins durch einen Blocker des KATP-Kanals aufheben ließ. In der vorliegenden Arbeit wurde nun außer-dem dargelegt, daß bei hoher Gabapentin-Konzentration der KATP-Kanal-Agonist Pinazidil keinen zusätzlichen hemmenden Effekt auf die [3H]-Noradrenalin Freisetzung aufweisen konnte, …
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Studies of the assembly pathway of human ATP synthase
Human mitochondrial ATP synthase is an enzyme containing 18 unlike subunits located in the inner mitochondrial membrane (IMM), where the catalytic F1 domain extends into the mitochondrial matrix and the FO domain, which contains the c8-ring rotor, the a-subunit and the supernumerary subunits, is …
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The action of selenite on ATP synthesis in rat lens
… opacification was preceded by a 15% decrease in ATP content. Lens ATP did not fully recover to control concentrations by 11 days post-injection. A moderate correlation existed between lens weight and total ATP content in control lenses <r=O.509, n=153), but this relationship disappeared with …
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Inhibition of <em>Escherichia coli</em> ATP Synthase Using Bioflavonoids.
<p>ATP synthase is the fundamental means of the cellular energy production in all organisms. Malfunction of ATP synthase is associated with multiple disease conditions. This enzyme is not only implicated in disease conditions but also likely to contribute in new therapies for multiple diseases by …
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Photosynthetic regeneration of ATP using native and immobilized bacterial chromatophores.
Thesis: Ph. D., Massachusetts Institute of Technology, Department of Nutrition and Food Science, 1976
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