Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"AT2"”.
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Kardiovaskuläre Phänotypisierung von Angiotensin II AT2-Rezeptor- und adrenergen Rezeptor-"Knockout"-Mäusen
Die Deletion des AT2-Rezeptors (AT2-KO) führt zu erhöhter Blutdruckempfindlichkeit und vaskulärer Hypertrophie durch Aktivitätszunahhme der P70S6-Kinase. Die Vasodilatation von Blutgefäßen wird maßgeblich durch beta1-adrenerge Rezeptoren vermittelt. Die Deletion von alpha2-adrenergen Rezeptoren …
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Angiotensin Type-2 (At2) Receptor Modulation of Nmda-Mediated Current, Signaling and Apoptosis
… revealed that Ang II, acting primarily through AT2 receptor activation of the protein phosphatase 2A (PP2A), attenuated NMDA-mediated increases in extracellular regulated kinase-2 (ERK-2) activity. We have identified that AT2 receptor activation inhibits cleavage of the DNA repair enzyme …
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Effets centraux d'antagonistes non-peptidiques sélectifs pour les récepteurs AT1 ou AT2 de l'angiotensine II chez le rat hypertendu spontanément
… un composé sélectif pour les récepteurs AT2 de l'Ang, administré par voie intracérébroventriculaire (icv), n'affecte pas la pression artérielle (PA) du SHR. Deux antagonistes non-peptidiques sélectifs pour les récepteurs AT, Losartan et L158809, induisent une réduction significative …
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The Role of the Transcription Factor CEBPA in Regulating Lung Alveolar Type 2 Cell Fate In Vivo
… (TF) CEBPA, specific to lung alveolar type 2 (AT2) cells, in modulating AT2 cell plasticity within the mouse lung. We demonstrate that CEBPA constrains AT2 cell plasticity by promoting the AT2 differentiation program and recruiting the lineage-specific TF NKX2-1. Without CEBPA, AT2 cells, in …
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Alveolar stem cell dynamics and regulatory mechanisms in homeostasis and early oncogenesis
… remain elusive. Although alveolar type II (AT2) cells, which act as stem cells in the alveolar epithelium, have been identified as key cells of origin of LUAD, little progress has been made in understanding the precise sequence of events that transform single AT2 cells into complex malignant …
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Role of Angiotensin II Type 2 Receptors in Oxidative Stress and Inflammation
… AT1 receptors. We have recently shown that renal AT2 receptors are upreguated in obese animal and contribute to natriuresis. However, the role of AT2 receptors in oxidative stress and inflammation is not well studied. On the other hand, oxidative stress can positively influence sodium retention …
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Rôles et mécanismes d'action du récepteur AT[indice inférieur 2] de l'angiotensine II d'un modèle cellulaire neuronal au tissu prostatique humain l'importance du contexte
Le récepteur AT2 de l'Ang II est un récepteur dont les rôles et les mécanismes d'action font l'objet de nombreux débats. Les raisons de cette controverse sont d'une part que les effets liés à son activation dépendent du modèle utilisé, et d'autre part à l'absence de ligand sélectif non-peptidique, …
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Role of Phosphorylated Dicer1 In Tumor Progression
… DICER1 is unique to transformed Alveolar Type 2 (AT2) cells and is not observed in wild-type lung alveolar cells. Furthermore, I find that the expression of phosphorylated DICER1 is much higher in the nucleus of AT2 tumor cells that harbor oncogenic <em>Kras</em> and phosphomimetic <em>Dicer1</em> …
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The effects of angiotensin-converting enzyme inhibitors as a pharmacological treatment for Dupuytren’s disease
… the presence of ANGT II receptors 1 (AT1) and 2 (AT2) in myofibroblasts derived from primary tissue of 11 patients who had the disease. My hypothesis is that myofibroblasts will express angiotensin receptors and that these will primarily be of the AT1 receptor subtype. Initially, the tissues were …
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The Genome-Wide Roles of The Lung Lineage Transcription Factor Nkx2-1 In The Regulation of Opposing Cell Fates In Vivo
… and scRNA-seq, our study shows that AT1 and AT2 cells both express and require Nkx2-1 for their development and maintenance through NKX2-1 mediated regulation of cell type-specific genes. Furthermore, NKX2-1 is guided by cell type-specific transcription factors, binding to regulatory elements …
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A Structural and Functional Analysis of the Human Angiotensin II Type-2 Receptor
… map the G-protein coupling regions of the human AT2 receptor and develop a wider understanding of AT2 receptor/G-protein interactions.
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Expression of myofibroblasts and identification of angiotensin receptors in capsular contracture disease around mammary implants
… of myofibroblasts and Ang-II receptors (AT1 and AT2) within breast capsule tissue were also investigated using immunohistochemistry. The results show that myofibroblasts were present in all capsules (n=12). Ang-II receptors were present in 50% (n=6) of capsules (paraffin and cryostat sections). …
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Sine Oculis Homeobox Homolog 1 (Six1) Plays A Critical Role In The Progression of Pulmonary Fibrosis.
… injury to the type II alveolar epithelial cells (AT2) specifically being a key player in the pathogenesis of IPF. Recent studies have shown that recapitulation of developmental genes in AT2 cells is associated with the abnormal epithelial phenotype seen in IPF, however the specific genes and<em> …
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Angiotensin's Role in Hypoxic Injury
In order to determine the mechanism in which the AT2 receptor protected cortical neuronal cultures from sodium azide-induced apoptosis. We show that K+ channels are required for AT2 receptor neuroprotection and more specifically the actions of the delayed rectifier K+ channel. We suggest that the …
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The Study of Nitric Oxide Synthase Expression, Function, and Regulation in the Renal Vasculature During Postnatal Renal Development
… patterns of NOS isoforms, renin, and AT1 and AT2 receptors in immature preglomerular resistance microvessels utilizing novel microdissection techniques; and (4) determine AII regulation of NOS expression and function in the immature renal vasculature using AT1 and AT2 receptor inhibitors.</p> …
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Identification and characterisation of novel interactors of surfactant protein C
… the plasma membrane and causes alveolar type 2 (AT2) dysfunction via a poorly understood toxic gain-of-function. Understanding the mechanisms of SFTPC trafficking and their interactors in health and disease is crucial to defining how pathogenic variants induce cellular dysfunction. To investigate …
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Investigating The Role of The P63 Isoform Δnp63 In Lung Stem Cell Populations and Lung Cancer
… lung progenitor populations of basal cells and AT2 cells. Analysis of ΔNp63-regulated pathways uncovered that ΔNp63 regulates cell-type-specific genes as well as common genes for basal cells and AT2 cells. Our experiments using a deactivated cas9 system showed that co-targeting of ΔNp63 and the …
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Cellular Ensembles in Alveolar Homeostasis and Repair
… alveolar stem cell, alveolar type-2 cells (AT2s) are sparsely distributed and make up only 5% of the surface area. Despite this organization, AT2s are still able to maintain tissue homeostasis and achieve efficient repair after injury. However, the underlying mechanisms of stem cell …
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Neuronale Effekte von lokal gebildetem Angiotensin II im menschlichen Vorhof
… einer der beiden Rezeptorsubtypen AT1 und AT2 inhibiert. Es wird anhand der erhobenen Daten eine Interaktion zwischen beiden Rezeptorsubtypen vermutet.
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Development of novel in vitro platforms to model the lung
… the culture of primary human alveolar type 2 (AT2) cells and iPSC-derived AT2 cells. One of the limitations of in vitro systems is the inability to culture primary cells, including AT2 cells, for a long time without loss in their phenotype and identity. Until recently, a feeder layer of …
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