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Showing 1 to 20 of 22 for “"ASCL1"”.
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Analysis of ASCL1 in Neuroendocrine Lung Cancer
… transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many pulmonary neuroendocrine (NE) cancer cells, which include both SCLC and some non-small cell lung cancer (NSCLC). To understand how ASCL1 initiates tumorigenesis in pulmonary neuroendocrine …
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Role of ASCL1 and Its Interactors in Neuroblastoma
… differentiation. Achaete-scute complex-like 1 (ASCL1) is a transcription factor required for both progenitor maintenance and neuronal differentiation in normal sympathoadrenal development. In NB, ASCL1 also has a dual role - as a component of the adrenergic CRC, ASCL1 supports cell …
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Characterizing ASCL1-Dependent Neuroendocrine Non-Small Cell Lung Cancers
… that a particular transcription factor, ASCL1, required during development for the formation of pulmonary neuroendocrine cells, is dramatically upregulated in the subgroup of non-small cell lung cancer with neuroendocrine features (NE-NSCLC). Other cancer models have demonstrated …
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Regulation of cell cycle and differentiation by ASCL1 in Glioblastoma
… I investigated if the transcription factor ASCL1 could drive neuronal differentiation in GSCs. ASCL1 is a key regulator of neurogenesis in the developing CNS and is sufficient to reprogramme fibroblasts, astrocytes and induced pluripotent cells into neurons. However, ASCL1 also promotes …
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Posttranskriptionelle Einflüsse auf die Expression des Transkriptionsfaktors Achaete-Scute Homolog-1 (ASCL1)
… Achaete-Scute Homolog-1 (ASCL1, hASH1) hat eine wichtige Funktion während der neuronalen Entwicklung. Er ist von Bedeutung für die Differenzierung bzw. die Subtypspezifizierung von neuronalen Zellen. Jedoch ist über seine direkte Regulation wenig bekannt. In silico-Analysen …
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Identification and characterization of Ascl1-expressing cells in maternal liver during pregnancy
… analysis revealed a most upregulated gene named Ascl1, a transcription factor essential for neural development, in the maternal liver at mid-gestation. The aims of the study were to (1) validate the activation of Ascl1 gene; (2) identify Ascl1-expressing cells; and (3) determine the fate of …
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Lineage tracing of Ascl1-expressing cells in the maternal liver during pregnancy
… up-regulation in the mRNA expression of Ascl1, a transcription factor responsible for the differentiation of neural progenitor cells into various neuronal types, during the second half of pregnancy. Our investigation aimed at (1) characterizing the identity of maternal hepatic …
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Context-dependent activity of a pioneer transcription factor, ASCL1, in early development
… these unanswered questions, using the proneural ASCL1 as a model pioneer TF. Using a mouse embryonic stem cell line with inducible ASCL1 activity, I showed that cells undergo ASCL1-directed neuronal differentiation after priming towards a neuroectoderm identity. However, pluripotent cells do not …
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Genome-Wide Analysis of Transcription Factors Ascl1 and Ptf1a in Development and Cancer
… The basic helix-loop-helix (bHLH) factors Ascl1 and Ptf1a are examples of factors that give rise to and function in multiple tissues. Ascl1 and Ptf1a are essential for generating the correct number and sub-type of neurons in multiple regions of the nervous system. In addition, Ptf1a is …
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Neurogenesis and Gliogenesis from Ascl1 (Mash1) Expressing Progenitors in the Central Nervous System
… to form the mature nervous system structures. Ascl1 (previously Mash1) is a bHLH transcription factor essential for neuronal differentiation and neural sub-type specification. Ascl1 is present in proliferating progenitor cells but these cells are actively differentiating as evidenced by their …
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The Role of the Proneural Transcription Factor ASCL1 in Neuroblastoma Cell Division and Differentiation
… and tumour clearance in neuroblastoma. ASCL1 is a master transcriptional regulator which modulates both proliferation and differentiation of sympathetic neuroblast precursor cells. During development, ASCL1 is transiently expressed and is downregulated as cells differentiate into mature …
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Proneural Genes in Neocortical Development
… by both intrinsic proneural genes Neurog2 and Ascl1, and extrinsic signals. However, how these intrinsic factors and extrinsic signals coordinatedly control neural cell fate decisions was not well understood at the start of my studies. Neurog2 and Ascl1 were known to be expressed by dorsal and …
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Molecular Regulation of Maternal Hepatic Adaptations to Pregnancy
… We found that achaete-scute homolog 1 (Ascl1), a basic helix-loop-helix transcription factor essential for neuronal development, is highly activated in maternal hepatocytes during the second half of gestation in mice. Our aim is to investigate whether and how Ascl1 plays a …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… dorsal spinal cord development, the bHLH factor Ascl1 is expressed in progenitors to dI3, dI4, and dI5 (dorsal interneurons 3-5) and is required for the glutamatergic neuronal fate. In contrast, another bHLH factor Ptf1a, is restricted in progenitors to dI4 and is required to specify the …
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Transcriptional Regulation of Neuronal Fate Specification by Proneural Genes in the Developing Neocortex
… factors encoded by Neurog1, Neurog2, and Ascl1. The activities of these proneural genes are tightly regulated, ensuring that neocortical neurons are born at their correct times and with their proper identities. I began my PhD project by investigating the connection between Neurog2 and …
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Intrinsic Specificity of Binding and Regulatory Function of Class II bHLH Transcription Factors
… of gene expression from the shared genome. ASCL1, ASCL2, and MYOD are class II basic Helix-Loop-Helix (bHLH) transcription factors which play crucial roles in lineage specification in the developing embryo. In vivo, these factors bind to distinct genomic sites, and regulate distinct …
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Defining oncogenic determinants in prostate cancer initiation and progression
… delineated critical roles of the pioneer factors ASCL1 and NEUROD1 in neuroendocrine transdifferentitation and uncovered their abilities to silence AR expression and signaling by remodeling chromatin at the somatically acquired AR enhancer and global AR binding sites with enhancer activity. We …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
… specific lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The expression of various MYC family members leads to further inter-tumor heterogeneity. Despite this heterogeneity in SCLC, the current treatment for SCLC is lineage-transcription-factor-subtype agnostic. Although …
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Dissecting combinatorial microenvironmental regulation of cell fate and function using a multi-modal arraying platform
… the presence or absence of the lineage oncogene ASCL1. Thus, this dissertation presents an advanced array platform which not only improves our understanding of biochemical and biophysical regulation of liver progenitor fate specification and lung tumor cell drug responses but also enables similar …
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Neural Stem Cells in Brain Tumor Development
… targeting transit amplifying cells using the Ascl1-creERT2 transgenic mouse, we show that tumor suppressor inactivation in the progenitor compartment alone induces malignant astrocytoma formation. Defects in proliferation, differentiation, and migration are likewise found several months prior …
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