Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 27 for “"AP1"”.
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A single molecule approach to investigate how AP1 transcriptional regulators find their target sites on DNA
… protein family members Activator Protein-1 (AP1) bind to their target site TGAC/GTCA during the normal cell cycle. Their over-expression is linked to the initiation of cancer. Regulating cFos and cJun interactions with AP1 binding sites is a potential cancer therapy strategy. How the proteins …
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A Role for Late Meristem Identity2 in the Reproductive Development of Arabidopsis
… LEAFY (LFY) and the LFY direct target APETALA1 (AP1 ). The molecular mechanisms by which LFY orchestrates a precise and robust switch to flower formation is not well understood. Here we show that the R2R3 MYB transcription factor and direct LFY target LATE MERISTEM IDENTITY2 ( LMI2 ) plays a role …
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Signalbindung und Membraninteraktion von heterotetrameren Adaptorprotein-Komplexen
Die heterotetrameren Adaptorprotein-Komplexe AP1, AP2, AP3 und AP4 sind an der Sortierung von Transmembranproteinen in der Zelle beteiligt. APs interagieren mit den Sortierungssignalen von Transmembranproteinen und vermitteln dadurch ihre Aufnahme in Transportvesikel. Da jeder AP vermutlich an …
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Role of the Sh3 and Cysteine-Rich Domain 3 (STAC3) Gene in Proliferation and Differentiation of Bovine Satellite Cells
… mechanism, we identified and validated AP1?1 as a STAC3-interacting protein by yeast two-hybrid screening and co-immunoprecipitation. In C2C12 cells, STAC3 knockdown decreased the expression level of AP1?1 protein. In bovine satellite cells, STAC3 knockdown increased the membrane …
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Untersuchungen zur Beeinflussung der Interaktion von AP 2 mit cytoplasmatischen Rezeptordomänen durch die Phosphorylierung und Dephosphorylierung von AP 2
… reguliert. Da die beiden Adaptorkomplexe AP1 und AP2 posttranslationell phosphoryliert werden, liegt die Vermutung nahe, daß die Interaktion zwischen den Adaptorkomplexen und den cytoplasmatischen Domänen bestimmter Rezeptorproteine und Transmembranproteine durch Phosphorylierung der …
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THE INTERACTION OF TRANSCRIPTION FACTORS WITH THE LONG CONTROL REGION OF HPV 16
… 7 binding sites for the factor NF1 and 3 for AP1 are involved in enhancer function. The work towards this thesis addressed detailed aspects of the activation through these 2 types of factors, and was aimed towards identification of additional factors involved in enhancer function. It was …
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FUNCTIONAL ANALYSIS OF TRANSCRIPTION FACTORS INVOLVED IN REPRODUCTIVE MERISTEM IDENTITY IN ARABIDOPSIS THALIANA
… LFY, LATE MERISTEM IDENTITY1 (LMI1), APETALA1 (AP1), CAULIFLOWER (CAL), SHORT VEGETATIVE PHASE (SVP) and AGAMOUS-LIKE 24 (AGL24). In fact, after the floral transition, the inflorescence meristem (IM) starts to produce floral meristems from its flanks. These meristems remain undifferentiated …
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Leveraging Single Cell Technologies For The Characterization and Treatment of Refractory Pancreatic Cancer
… I describe a novel HDACi resistance mechanism of AP1 activation, which can be intercepted by using an AP1 inhibitor in combination with an HDAC inhibitor to achieve tumor cell death. Finally, in an effort to explore and characterize the molecular consequences of newly-developed KRAS inhibitors in …
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Über die Beteiligung EGF-Rezeptor-vermittelter Signaltransduktionswege an den tumorpromovierenden Effekten von 2-Acetylaminofluoren, 2-Nitrosofluoren und Phenobarbital in HepG2-Zellen
… Die Bindungsaktivität der Transkriptionsfaktoren AP1 und NFkappa B wurde durch 2-NOF und Phenobarbital erhöht, wohingegen der Effekt von 2-AAF nicht endeutig zu klären war.
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Expanding the molecular tools for the microalgae Chlorella vulgaris and Phaeodactylum tricornutum
… lacks strong, inducible promoters. As such the *AP1* promoter (P<sub>*AP1*</sub>), upregulated under conditions of phosphate stress, and the METE promoter (P<sub>*METE*</sub>), upregulated in the absence of vitamin B<sub>12</sub> (B<sub>12</sub>), were investigated accordingly to bring the …
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Untersuchungen zur Rolle von Wnt5a beim Basalzellkarzinom
… und möglicherweise auch der Wnt/JNK/AP1-Signalweg in den Tumoren aktiv sind. Der Wnt/β-Catenin-Weg dagegen scheint inaktiv zu sein. Aufgrund dieser Daten und unter Berücksichtigung weiterer Ergebnisse der Arbeitsgruppe kann man folgende Hypothese zur Rolle von Wnt5a beim BCC …
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Der Wnt-Signalweg in der Makrophagen-induzierten Invasion von Brustkrebszellen
… Studien offenbarten die JNK sowie den c jun/AP1-Komplex und damit den promigratorischen PCP Signalweg als für die Invasionssteigerung kritischen Wnt 5a Effektor in MCF-7-Zellen. In den Makrophagen konnte MMP 7 als ein wichtiger Wnt abhängiger Faktor identifiziert werden. Wnt5a stellt somit …
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Pathogenetische Bedeutung der induzierbaren Stickstoffmonoxid-Synthase für den akuten hyperoxischen Lungenschaden
… NF-Kappa B und Aktivatorprotein 1 (AP1) vermittelt wurde. Diese Auswirkungen waren auch in den histologischen Schnitten zu beobachten. Als Zeichen vermehrten oxidativen Stresses war eine erhöhte Lipidperoxidation zu verzeichnen. Die genannten Beobachtungen waren bei den …
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Vimentin Overexpression Contributes To the Biological Properties of Metastatic Head and Neck Cancer Cells
… promoter, while TGF-β is likely to act in an AP1-dependent manner. Furthermore, both growth factors appear to synergize by stimulating promoter activation through the ASE site, suggesting involvement of Stat-dependent pathways in regulation of vimentin expression in HN12 cells.
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CHARACTERIZATION OF GENETIC AND EPIGENETIC MODIFICATIONS IN A MODEL OF INFLAMMATION-DRIVEN CANCER
… accompanied by the activation of members of the AP1 transcription factor family. In parallel, by whole exome sequencing, we observed a high frequency of copy number amplifications and a very low number of point mutations in HCC nodules. Copy number variations occurrence was directly correlated to …
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Identification of MEN1 loss-off function as a potential biomarker for immune checkpoint therapy
… genes, specifically BRCA1, RAD51, and RAD51-AP1. Menin appears to regulate genes through transcriptional regulation but in some cases, such as the stabilisation of FANCD2, also via direct protein binding. MEN1 mutation predisposes to multiple endocrine neoplasia 1 syndrome, characterised by …
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Identification of a Minimal Cis-element and Cognate Trans-factors Required for the Regulation of Rac2 Gene Expression during K562 Cell Differentiation
… indicated binding by the transcription factor AP1 to three distinct binding sites within the 135 bp minimal regulatory region. PMA stimulation of K562 cells led to extensive changes in chromatin structure, including increased histone H3 acetylation, within the 135 bp Rac2 cis-element. These …
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Effect of ATF2 transcription factor on DLL4 gene expression in angiogenesis
INTRODUCTION: ATF2 belongs to the AP1 transcription factor family that homodimerize or heterodimerize with other members of the bZIP family and regulates the transcriptional activation of target genes. Previous studies have shown that ATF2 mediates VEGF-induced angiogenic processes but the …
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Evidence and Sustenance in Transnational Indigenous Literatures
… on evidence. I explore the “archival poetics” (AP1) and “ethnographic refusal” (A. Simpson 95) in the works of Hansda Sowvendra Shekhar, Jeanine Leane, Natalie Harkin, and Wendy Rose. Chapter 2 explores the literary manifestation of land-based Indigenous philosophies. I examine Adivasi mythology …
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Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms.
… pyogenes strain (serotype M1 strain AP1) were investigated in 73 patients with acute poststreptococcal glomerulonephritis (AGN). Antibody responses to the serotype M1-related antigens M1, protein H and streptococcal inhibitor of complement were increased in patients compared to …
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