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Showing 1 to 20 of 183 for “"AMPK"”.
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Roles of AMPK in Drosophila circadian clock
… 10 H. 면역침강법 (ImmunoPrecipitation; IP) 12 1. AMPKγ 와 dCLK 또는 dCLKΔ657-707 간의 상호작용 확인 12 2. dCLK과 AMPK α, β, γ subuit 간의 상호작용 확인 13 I. Tandem affinity purification (TAP) 15 J. 면역조직화학 (Immunohistochemistry) 16 Ⅲ. 결과 18 A. S2 세포에서 dCLK은 AMPK와 결합한다. 18 B. tim 발현 세포에서 …
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Regulation and role of the LKB1-AMPK pathway
The AMP-activated protein kinase (AMPK) is a sensor of cellular energy that is activated by increases in the intracellular AMP:ATP or ADP:ATP ratios. Once active, AMPK activates catabolic pathways and inhibits anabolic pathways to restore cellular energy homeostasis. AMPK activity can be increased …
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The Bca2 And Ampk Paradigm: Unraveling The Cancer Connection
<p> <strong>THE BCA2 & AMPK PARADIGM: UNRAVELING THE CANCER CONNECTION</strong> </p> <p>By</p> <p> <strong>DANIELA (BUAC) VENTRO</strong> </p> <p>December 2013</p> <p>Advisor: Dr. Q Ping Dou and Angelika M. Burger (deceased)</p> <p>Major: Cancer Biology</p> <p>Degree: Doctor of Philosophy</p> …
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The AMPK signalling pathway in cancer and DNA damage
AMP-activated protein kinase (AMPK) is a master regulator of energy homeostasis and metabolism, both at the cellular and at the whole body level. It acts as a cellular fuel gauge, sensing changes in AMP: ATP or ADP: ATP ratios. Once activated by energy deficit, AMPK switches on catabolic processes, …
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The Role of Amp-Activated Protein Kinase (Ampk) In Tumorigenesis
<p>AMPK plays a central role in controlling cellular and whole body energy level. Increasing studies have also discovered the diverse function of AMPK in cancer, such as autophagy and mitochondria biogenesis. However, how AMPK promotes cancer progression is still not clear. Here, we show that AMPK …
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Exploring the molecular mechanisms of AMPK-dependent regulation of neuroexcitability
The AMP-activated protein kinase (AMPK) is an energy sensor that maintains cellular metabolic homeostasis in a cell-autonomous manner during energy stress conditions, such as hypoxia and glucose deprivation. Emerging evidence suggests that AMPK activation during metabolic stress conditions may have …
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PALMITATE INDUCED ENDOTHELIAL DYSFUNCTION: THE ROLE OF CALPAIN, AMPK AND ENOS
… exposure dose dependently reduced endothelial AMPK thr172 and eNOS ser1177 phosphorylation by western blot. Moreover, our study demonstrated that endothelial calpain, a calcium dependent protease associated with endothelial dysfunction, was activated by palmitate, specifically its μ-calpain …
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AMPK Regulation of Myeloid Inflammatory Responses During Acute and Chronic Disease
AMPK is a heterotrimeric kinase that shifts cellular metabolism to favour catabolism once activated by changes in glucose, adenine nucleotide, fatty acid, or calcium levels. Innate immune cells such as macrophages must rewire metabolic signaling to efficiently respond to inflammatory insults. In …
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AMPK-MEDIATED LONG-TERM REGULATION OF HCN4CONTRIBUTES TO AGE-RELATED SINUS BRADYCARDIA
… of this condition. Among protein kinases, AMPK activation has been shown to induce a cardiac remodeling that leads to sinus bradycardia. In this context, this work highlights a possible mechanism through which AMPK regulates HCN4 channels and explores how this mechanism may be linked to the …
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AMP- Activated Protein Kinase (AMPK) Activation for the Treatment of Mitochondrial Disease
… ETC activity. 5' AMP-activated protein kinase (AMPK) is a kinase that can initiate mitochondrial biogenesis and mitophagy. We hypothesized that treating cells harbouring low numbers of mtDNA with an AMPK activator (5-Aminoimidazole-4-carboxamide ribonucleoside; AICAR) would ameliorate the …
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Exploring The Impact of Decreased Ampk Pathway Activity On Brain Injury Outcome
… cellular metabolism. AMP-activated kinase (AMPK) is a kinase that senses low ATP levels, and promotes efficient cell energy usage. AMPK promotes energy production through increasing glucose uptake via glucose transporter 4 (GLUT4). When AMPK is activated, it phosphorylates Akt Substrate of …
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LKB1 signaling pathways in adipocytes - Focus on the AMPK-related kinase SIK2
… processes. AMP-activated protein kinase (AMPK) is known for its various roles in the regulation of metabolism and is activated when cellular energy levels are low, which is reflected in increased levels of AMP. In addition to AMPK, some of its related kinases, including the salt-inducible …
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Mechanotransduction of subcellular AMPK and its role in breast cancer cell migration
… Src and FAK) in AMP-activated protein kinase (AMPK) activation in breast cancer cells in response to interstitial fluid flow. Additionally, we explored the involvement of AMPK in breast cancer cell migration. An in-vitro three-dimensional (3D) cell culture model utilizing collagen-Matrigel …
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Investigation of plant derived compounds mediating cell signalling effectson FOXO1a and AMPK
… cell signalling effects on FOXO1a and AMPK. The pilot data established that one extract (grape seed, GSE) induces regulation of AMPK and FOXO1a much more readily than another (pine bark, PBE). GSE and PBE were subjected to multiple fractionation methods and mass spectrometry to learn …
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Inhibition of AMPK via phosphorylation at Ser485/491: multiple mechanisms of regulation
AMP-activated protein kinase (AMPK) is an energy-sensing enzyme that is activated when cellular energy is low and causes muscle and other cells to increase glucose uptake and fat oxidation, diminish lipid synthesis, and alter expression of various genes. AMPK activity is diminished in animals with …
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How cellular ATP/ADP ratios and reactive oxygen species affect AMPK signalling
… the activity of AMP-activated protein kinase (AMPK), a key metabolic sensor and regulator of cell metabolism, which is activated when cellular ATP levels decrease during energy demand. Mitochondria can signal to AMPK via the magnitude of the cellular ATP/AMP and ATP/ADP ratios, which alter in …
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Molecular cloning of three genes encoding SNF1/AMPK protein kinases from Drosophila melanogaster.
… the mammalian AMP-activated protein kinases (AMPKs), known to regulate fatty acid and sterol metabolism in response to stress, represent the mammalian homologues of SNF1. Three novel Drosophila protein kinases were cloned and found to represent homologues of previously reported protein …
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Phosphorylation of Skeletal Muscle Acetyl-CoA Carboxylase by AMPK Enhances Palmitoyl-CoA Inhibition
… been well documented that AMP activated kinase (AMPK) when activated phosphorylates and inactivates ACC. ACC is controlled allosterically by citrate, which activates, and by palmitoyl-COA, which inhibits. In this study, we asked the question, "Does phosphorylation by AMPK effect the inhibition of …
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Control metabólico de la sensibilidad a TRAIL en células epiteliales de mama : papel de AMPK
… por TRAIL. La quinasa dependiente de AMP, AMPK, es el sensor del estado energético celular, que cuando se activa es capaz de inhibir el metabolismo anabólico e inducir al mismo tiempo el catabólico, con el fin de restablecer los niveles de AMP/ATP intracelulares antes de que el ciclo …
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