Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 26 for “"ALCL"”.
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Searching for the missing T Cell Receptor (TCR) in Anaplastic Large Cell Lymphoma (ALCL): Surplus to requirements or a protagonist in lymphomagenesis?
Anaplastic Large Cell Lymphoma (ALCL) is a peripheral T cell lymphoma divided into three distinct entities: ALCL, Anaplastic Lymphoma Kinase (ALK)+, ALCL ALK- and cutaneous ALCL. In the majority of ALCL, ALK+, ALK is expressed as the result of a chromosomal translocation generating Nucleophosmin …
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Effect of maleic acid on the selectivity of glucose and fructose dehydration and degradation
… describe the kinetic analysis of a Lewis acid (AlCl<sub> 3</sub>) alone and in combination with HCl or maleic acid to catalyze the isomerization of glucose to fructose, dehydration of fructose to HMF, hydration of HMF to levulinic and formic acids, and degradation of these compounds to humins. …
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Investigating the genome of Anaplastic Lymphoma Kinase-positive Anaplastic Large Cell Lymphoma
Anaplastic Large Cell Lymphoma (ALCL) is a T cell Non-Hodgkin Lymphoma, mainly presenting in paediatric and young adult patients. The majority of cases express a chimeric fusion protein resulting in hyperactivation of Anaplastic Lymphoma Kinase (ALK) as the consequence of a chromosomal …
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ALK in the pathogenesis of cancer
… cancer including Anaplastic Large Cell Lymphoma (ALCL) and neuroblastoma (NB). ALK is an ideal drug target as its endogenous expression is limited to neuronal cells during neonatal development, although resistance to ALK-targeted therapy has been observed. In this thesis I explore potential …
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Novel treatment strategy for ALK-positive Anaplastic Large Cell Lymphoma
… (ALK)-positive anaplastic large cell lymphoma (ALCL) is a T-cell non-Hodgkin lymphoma characterised by a chromosomal rearrangement [t(2;5) (p23;q25)] involving the ALK and NPM1 genes on chromosomes 2 and 5 respectively. This translocation generates the NPM-ALK fusion protein, a hyperactive …
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Studying the Transcriptional and Epigenetic Perturbations of Haematopathologies Expressing NPM1-ALK
… including anaplastic large cell lymphoma (ALCL), diffuse large B-cell lymphoma (DLBCL), and non-small cell lung cancer (NSCLC). In addition to oncogenic fusion proteins, ALK is activated as a consequence of amplification and mutation in neuroblastoma (NB); a malignancy of the peripheral …
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Molecular to Macroscopic Understanding of Chloroaluminate Anion Intercalation in Rechargeable Aluminum-Graphite Batteries
… chloroaluminate molecular anions (<em>e.g.,</em> AlCl<sub>4</sub><sup>-</sup>) intercalate into graphite. Such aluminum-graphite batteries exhibit discharge voltages of <em>ca.</em> 2 V, high cycle life, and ultra-fast rate capabilities. However, it remains unclear how the electrochemical …
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Solid state nuclear magnetic resonance spectroscopic studies of quadrupolar nuclei in inorganic systems and determination of optical parameters in optical waveguides
… materials, such as group III-V semiconductors, AlCl$\sb3\cdot$THF complexes, graphite intercalated with AlCl$\sb3$ (and related systems), and the copper-free high T$\sb{\rm c}$ superconductor (Ba$\sb{0.6}$K$\sb{0.4}$BiO$\sb3$), and related systems. Overall, I have tried to use solid-state NMR to …
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A MODEL SYSTEM FOR THE CONCENTRATION OF REOVIRUS FROM AQUEOUS ENVIRONMENTS
… was enhanced by 50 mM MgCl(,2). The use of AlCl(,3) as an enhancing salt was contraindicated since reovirus was not recoverable from 0.5 mM AlCl(,3) solutions. Elution of virus was most effective when a 3% beef extract eluent was used. In the model system, reconcentration of eluates was …
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Investigating the Genomics and Heterogeneity of Childhood Non-Hodgkin Lymphoma
… lymphoma (BL), Anaplastic Large Cell Lymphomas (ALCL), and lymphoblastic lymphomas. Most childhood NHL is high-grade and generally responds well to high-intensity chemotherapy. Unfortunately, many patients who relapse have a dismal prognosis, with long-term survival less than 30% for relapsed BL …
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Multilevel Deregulation of Survival Mechanisms In Npm-Alk+ T-Cell Lymphoma
… large-cell lymphoma (NPM-ALK<sup>+ </sup>ALCL). The oncogenic potential of NPM-ALK has been demonstrated by several studies using <em>in vitro</em> assays as well as transgenic mouse models.</p> <p>NPM-ALK<sup>+ </sup>ALCL is an aggressive subset of T-cell lymphoma that predominantly …
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Maligne Lymphome – Molekulare Mechanismen und therapeutische Implikationen deregulierter Signalwege
… (cHL), des anaplastischen großzelligen Lymphoms (ALCL) sowie des Sézary-Syndroms, einer Sonderform kutaner T-Zell-Lymphome, erhoben werden. Insbesondere wurde im cHL und ALCL u.a. die pathogenetisch wichtige aberrante AP-1-Aktivität beschrieben, und es wurden Mechanismen der Apoptoseresistenz oben …
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The ring opening polymerization of ring strained cyclic ethers
… these results. The stereochemistry of [(TPP)AlCl] catalyst was investigated using cyclohexene and cyclopentene oxide monomers, using extensive 1H NMR, 2-D COSY and decoupling NMR techniques it was concluded that [(TPP)AlCl] gave rise to stereoregular polymers.
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Molecular Spectroscopy: A Study of Molecules in Earth and Planetary Atmospheres
… included in the energy level calculations for AlCl. Ro-vibrational energy levels were calculated for the v=0 to v=11 vibrational levels and up to J<sub>max</sub> =200 for the rotational levels. Dipole moment functions (DMFs) covering the range of the PES turning points were calculated for AlCl …
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Corn response to long-term application of CuSO₄, ZnSO₄ and Cu-enriched pig manure
… order for the control and CuSO₄, treatments: AlCl₃ in O.5M HC1 > EDTA > DTPA. A different order of Cu extraction occurred for the Cu-enriched pig manure treatment such that EDTA > DTPA > AlCl₃ in 0.5M HC1. Extractable Cu decreased with time regardless of Cu source.
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Quantification des propriétés thermophysiques des nanofluides
… sont 29 nm pour CuO-eau, 36 et 47 nm pour ALCL-eau. Le principe de l’appareil de mesure de la conductivité thermique utilisé est la méthode du fil chaud (hot-wire method). Le viscosimètre de l’étude est de type piston. Les résultats montrent que la conductivité thermique du nanofluide …
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Electrochemical behavior of a liquid tin electrode in molten ternary salt electrolyte containing sodium chloride, aluminum chloride, and tin chloride
… materials. In this thesis, the molten NaCl-AlCl3-SnCl2 electrolyte and liquid Sn electrode couple at 250 °C is investigated as part of the potential cell Na I NaCl-AlCl 3-SnCl2 I Sn for a lower temperature molten salt battery. An electrochemical study of the kinetics in the molten salt …
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Dielectric and Kerr Effect Studies of Electro-Active Polymer Complexes
… of biphenyl in solution in cyclohexane using AlCl₃/CuCl₂ catalysts gave predominantly para-substituted polyphenylenes and relatively large amounts of the odd-membered oligomers. A reaction scheme has been prepared to account for these observations. The dielectric and electro-optical properties …
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