Global ETD Search
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Showing 1 to 14 of 14 for “"ADAM17"”.
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Chemoresistenz-Übertragung durch extrazelluläre Vesikel im Ovarialkarzinom
… Vesikel, als auch für die Protease ADAM17 gibt es deutliche Hinweise für eine Beteiligung an der Entstehung und Vermittlung von Therapie-Resistenzen. Ziel dieser Arbeit war die Untersuchung einer Resistenzentstehung und -vermittlung durch ADAM17-haltige EV aus Ovarialkarzinomzellen. …
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Validierung eines 3D Ovarialkarzinommodells für die translationale Testung einer Kombinationstherapie aus Chemotherapeutikum und Rezeptor-Tyrosinkinase Inhibitoren
… das im Ovarialkarzinom stark exprimierte Enzym ADAM17 durch Cisplatin verstärkt aktiviert wird und über die Freisetzung von Wachstumsfaktoren pro-proliferative und anti-apoptotische Signalwege stimuliert. Ziel dieser Arbeit war es, die Bedeutung von ADAM17 und nachgeschalteten Signalwegen als …
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Characterisation of the molecular mechanisms of EGFR signal transactivation in human cancer
… of cannabinoids. Moreover, this study reveals ADAM17 and HB-EGF as the main effectors of this mechanism in most of the cancer cell lines investigated. However, depending on the cellular context and GPCR agonist, various different members of the ADAM family are selectively recruited for specific …
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Determining The Mechanisms Generating Soluble Il-15 Complexes
… test my hypothesis that Type I IFN signaling and ADAM17 are necessary for generating sIL-15 complexes. In Bone marrow dendritic cells, Type I Interferon (IFN) directly regulates the cleavage of sIL-15 complexes using the metalloprotease ADAM17. Mice with the conditional deletion of ADAM17 or a …
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Avaliação de genes auto inflamatórios em crianças com Síndrome Inflamatória Multissistêmica Pediátrica (SIM-P) associada à infecção pelo SARS-CoV-2
… (SNVs) were identified in five different genes (ADAM17, CARD14, IKBKG, PSTPIP1, and SH3BP12). All these variants were found in children/adolescents with the severe form of MIS-C. Notably, two variants (rs1200631089 and rs144458353) in the ADAM17 gene were selected. This gene encodes a protease …
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Identification of novel determinants of primary and acquired resistance to EGFR-targeted therapies in colorectal cancer
… can mediate activation of the metalloproteinase ADAM17, which has also been shown to mediated shedding of TGFα, we investigated if ADAM17 played a role in acute cetuximab resistance in this context. As such, we demonstrated that inhibition of ADAM17 either through siRNA silencing or with the use …
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Molecular Players in Lupus: Leads from Proteomic Screens
… leukocytes by proteases ADAM10 and TACE (ADAM17) to abrogate macrophage anti-inflammatory signaling through Twist. I further find that β-catenin is dysregulated in SLE but the deletion of β-catenin in lupus-prone macrophages does not appreciably change disease course. Lastly, I find that …
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The role of the P2Y2 nucleotide receptor in salivary gland regeneration
… via a disintegrin and metalloproteinases (ADAM10/ADAM17) and the [alpha-5 beta-1] integrin/Cdc42 Rho GTPase signaling pathway. This study sheds light on the P2Y2R as a target in salivary gl and reconstitution strategies and introduces [alpha-5 beta-1] integrin and Cdc42 as novel downstream …
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Genome-wide association study of muscle traits in Icelandic sheep
… í íslensku sauðfé. Þessi gen eru CSF3R, ADAM17, GADD45B, GRID2, SPG11, DAB2, FREM3, GAB1, KLF13, AKAP6, PNN, DOCK1 og TRRAP. GADD45B hefur virkni sem tengist stjórnun á vexti og frumudauða. Það var raðgreint í 11 sýnum, sýnin voru borin saman og borin við genið í viðmiðunarerfðamengi …
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Cellular regulation of platelet glycoprotein VI : in vivo and in vitro studies in mice
… GPV is cleaved in vitro by the metalloproteinase ADAM17. In previous studies it was shown that injection of mice with the anti-GPVI mAb, JAQ1, induces GPVI down-regulation, which is associated with a strong, but transient, thrombocytopenia. Using new anti-GPVI mAbs, which bind different epitopes …
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Augmenting Natural Killer cell antibody binding to enhance ovarian and prostate tumor cell killing via ADCC
… IgG with low affinity and is rapidly cleaved by ADAM17 upon activation, limiting therapeutic mAb efficacy. NK adoptive cell transfer has been shown to be effective for treating many cancer types, but strategies that enhance NK cell cytolytic activity have not been thoroughly investigated for the …
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Platelet phenotype distinguishes ITP from isolated thrombocytopenia
… TLT-1 shedding involved both ADAM10 and ADAM17. Results showed that TLT-1 release during coagulation was FXa-dependent, suggesting a coordinated FXa-driven shedding for GPVI and TLT-1 to modulate platelet activation. Elevated sTLT-1 levels were associated with trauma-induced coagulopathy, …
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Neutrophil Regulation of Colitis
The delicate intestinal homeostasis is regulated by interactions between microbiota, intestinal epithelial cells (IECs), and the intestinal immune system. As a crucial component of the innate immune system, neutrophils are the first responders to sites of inflammation when the intestinal epithelial …
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Contribution of Interleukin 6 Trans Signaling In Pulmonary Fibrosis
<p>Idiopathic Pulmonary Fibrosis (IPF) is a lethal lung disease with progressive fibrosis and death within 2-3 years of diagnosis. IPF incidence and prevalence rates are increasing annually, and because the pathogenesis is unknown, there are no effective treatments available. Inhibition of …