Global ETD Search
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Showing 1 to 20 of 24 for “"ADAM10"”.
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Characterization of ADAM10 in cervical and oesophageal cancers
A Disintegrin And Metalloproteinase 10 (ADAM10) is a cell surface molecule that activates proteins such as: adhesion molecules, cytokines, and growth factors. ADAM10 has been associated with the proliferation and metastasis of cancers including, breast, lung, and colon. While ADAM10 has been …
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ADAM10: a Novel Regulator of Mast Cell Function and Activation
… our knowledge, the first description of the role ADAM10 plays on mast cells. ADAM10 is abundantly expressed on mast cells both in vitro and in vivo. Its expression is inhibited by IL-10, a suppressive cytokine. siRNA depletion of ADAM10 on bone marrow-derived mast cells (BMMC) caused decreased …
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The effect of glucagon-like peptide-1 (GLP-1) receptor agonists on cell viability, ADAM10 maturation and the proteolysis of ADAM10 substrates in SH-SY5Y cells
… can enhance the amount of membrane-associated ADAM10. The current study, therefore, aims to determine firstly; whether GLP-1 analogues can protect neuroblastoma, SH-SY5Y cells, against chemical stressors of relevance to AD and, secondly, whether these compounds alter ADAM10 maturation/activity …
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Modulating ADAM-10 activity and expression in cervical and oesophageal cancer cells
… have linked a range of ADAMs, which include ADAM10 to cancer development and progression. Research in our laboratory found endogenous ADAM10 levels to be higher in both oesophageal and cervical cancer cell lines. Reports in the literature have highlighted a correlation between high levels of …
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B cell ADAM10 Activity is Increased by Kainate Receptor Activation: Potential Role of this Pathway in Th2 Immunity and Cancer
… in CD23 shedding, however we did find a role for ADAM10. Using ADAM10 KO MEFs and ADAM10 specific inhibitors, we discovered that ADAM10 is indeed the CD23 cleaving enzyme or “sheddase”. Thus, developing strategies that would target ADAM10 could have an effect on sCD23 release and IgE production. …
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The role of Fyn and B-cell expressed ADAM10 in early B cell development, germinal center formation and terminal B cell differentiation
… sought to determine the role of Fyn kinase and ADAM10 in B cell biology. A disintegrin and metalloproteinase 10 (ADAM10) is a zinc dependent proteinase related to matrix metalloproteinases. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains …
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Mechanisms Regulating Amyloid Processing Enzymes in HIV-Associated Neurotoxicity
… of APP by the non-amyloidogenic secretase ADAM10. BACE1 is increased in HAND as well as in our cell culture model of HIV neurotoxicity. Additionally, ADAM10 is decreased in response to excitotoxicity, a process crucial to HAND pathology, suggesting that there might be a shift in APP …
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The Role of ADAM10 in the Immune System: Maintenance of Lymphoid Architecture, MDSC Development and Function, B cell Derived Exosomal Antigen Presentation, and B1 cell IgE Production.
ADAM10 is a zinc-dependent metalloprotease. ADAM10 has emerged as a key regulator of cellular processes by cleaving and shedding extracellular domains of multiple transmembrane receptors and ligands. In this study, we examined the role of ADAM10 in the immune system. Here, we show that knocking out …
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MOLECULAR MECHANISMS REGULATING SPINE REMODELLING
… can be cleaved by the metalloproteinase ADAM10. Here we demonstrate that modulating ADAM10 localization and activity at synaptic sites regulates its processing of N-Cadherin. This indices modification of dendritic spines morphology and of composition and function of AMPA receptors. In …
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APP Processing: A Biochemical Competition Influenced by Exercise-Induced Signalling Mediators
… There were no statistical differences in ADAM10 and BACE1 mRNA or protein expression with post-exercise serum treatment at either time point. However, there was an increase in the ratio of sAPPα to sAPPβ protein content (p=0.05) after 30 minutes of post-exercise serum treatment. …
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The role of human CD23 in lgE homeostasis & allergic disease
… (mCD23) by the<br/>endogenous metalloprotease, ADAM10. It has been suggested that trimeric sCD23 fragments can co-ligate membrane IgE (mIgE) and membrane CD21 (mCD21) on the surface of human B cells, in a similar way to C3d-antigen complexes and mIgM, to upregulate IgE synthesis and provoke …
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CD23's Role as a Negative Regulator of Allergic Disease: in vivo Effects of Murine CD23 Destabilization and Allelic Mutations
… candidate CD23 sheddases. Through the use of an ADAM10 inhibitor, we blocked CD23 shedding from murine B cells while increasing CD23 surface levels, and thus we identified ADAM10 as the CD23 sheddase. During the course of the ADAM investigation, we discovered that the 129/SvJ inbred mouse strain …
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A Family-Based Association Study of Conduct Disorder.
… them are located in known genes. Two genes, <em>ADAM10</em> and <em>CAMK2A</em>, which had been reported associated with Alzheimer's disease (AD), bipolar disorder, and depression, were of more concern. Using IMAGE sample, our results were well replicated.</p><p>This study identified several CD …
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Molecular Players in Lupus: Leads from Proteomic Screens
… CD19+ and CD11b+/CD14+ leukocytes by proteases ADAM10 and TACE (ADAM17) to abrogate macrophage anti-inflammatory signaling through Twist. I further find that β-catenin is dysregulated in SLE but the deletion of β-catenin in lupus-prone macrophages does not appreciably change disease course. …
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Determining the mechanism of dichloroacetate-regulated processing of the Alzheimer’s disease-related amyloid precursor protein
… non-amyloidogenic pathway, α-secretase (ADAM10) cleaves APP within the A-domain thereby precluding the formation of intact toxic peptides. We have recently shown that orphan drug dichloroacetate (DCA) can inhibit the detrimental amyloidogenic APP processing pathway whilst boosting the …
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Identification of the TPC2 interactome reveals TSPAN10 and OCA7 as key players in the biogenesis of melanosomes
… the pigmentation associated metalloproteinase, ADAM10, and is required for ADAM10 expression and localization to endosomal compartments. On the other hand, OCA7 was found to work with the melanosome localized Rab proteins, Rab32 and Rab38, and regulates the pH of melanosomes. Thus, the newly …
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Hedgehog - like Proteins are Involved in a Novel Glia - Neuron Signalling Pathway in C. elegans
… the amphid neurons. SUP-17 is a homolog of the ADAM10 metalloprotease, and TSP-14 is a homolog of TspanC8 tetraspanin family, which are known to modulate the maturation, localisation, and function of ADAM10. FIG-1 does not have a clear homolog in mammals, but its structure loosely resembles a …
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Serotonergic Signaling Pathways that Suppress Amyloid Beta in Mouse Models of AD
… Finally, we show that selective inhibition of ADAM10, the primary alpha-secretase, is unable to block the beneficial effects of SSRI antidepressants in transgenic mice. These discoveries explain the mechanisms regulating amyloid beta reduction by serotonin activity and also offer a more …
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Crosstalk between CX3CL1 and the Cytoskeleton during Vascular Inflammation
… CX3CL1 and the membrane-associated protease ADAM10, thereby controlling the proteolytic release of soluble chemokine. Moreover, I discuss the implications of this mechanism in the recruitment of leukocytes during atherosclerosis, as well as the implications for membrane protease-substrate …
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EVALUATING SOLUBLE AXL AS A BIOMARKER FOR GLIOBLASTOMA
… sAXL, is the product of enzymatic cleavage by ADAM10/17. Here we used ELISA, BCA and BCG assays to characterize blood serum from 23 newly diagnosed GBM patients which was collected roughly 24 hours before and after surgery as well as every three months post-surgery, corresponding to follow-up …
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