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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 179 for “"AAA"”.
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Mechanistic studies of a AAA+ protease
AAA+ proteases are present in all branches of life and responsible for the energy-dependent degradation of most cytosolic proteins. Substrates for AAA+ proteases are unfolded and translocated into a compartmental peptidase. The requirement for protein unfolding raises several questions. How easily …
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Functional and structural studies of AAA+ proteases
AAA+ proteases are found in all domains of life. They degrade misfolded proteins as well as specific regulatory factors and thus play critical roles in protein quality control and numerous cellular processes. These enzymes share a conserved architecture in which a hexameric AAA+ ATPase recognizes, …
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Mechanistic studies of the AAA+ molecular motor ClpXP
ClpX is an archetypical representative of the AAA+ superfamily of enzymes that serves as the regulatory domain and motor for the ClpXP protease system. ClpX binds protein substrates via an amino acid sequence known as a tag, denatures them, and translocates them into the associated peptidase, ClpP. …
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Analyzing Resistance to Design Chemical Inhibitors of AAA Proteins
… design of chemical probes for proteins from the AAA (ATPase Associated with diverse cellular Activities) superfamily, for which only a few inhibitors are available. As the number of inhibitor-bound models of AAA proteins is also limited, the key protein-inhibitor interactions needed for design of …
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Mechanisms of substrate recognition by the AAA+ protease HslUV
… not a property of the accessory domains of other AAA+ protein unfolding machines.
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Mechanisms of CipS reprogramming of the AAA+ protease CipAP
… occur. These peptidase chambers can partner with AAA+ (ATPases Associated with various cellular Activities) unfoldases, protein machines that control substrate access to this chamber. An additional level of control is provided by adaptor proteins, which modulate substrate selection by the AAA+ …
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Specificity and regulation of substrate degradation for a AAA+ protease
… cellular regulation for all forms of life. The AAA+ proteases ClpXP and ClpAP in E. coli function in this capacity by facilitating the denaturation and degradation of target substrates. These proteolytic enzymes degrade hundreds of different proteins. Determining how the activities of these …
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Interaction between the AAA+ protease CIpXP and the adaptor protein SspB
… protease complexes, each consisting of a AAA+ ATPase and a peptidase component. Substrate selection by the proteases is a highly regulated process to ensure minimal errant protein degradation. Substrates are usually recognized by proteases through degradation tags or degrons. Accessory …
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Mechanism of active substrate delivery by the AAA+ protease adaptor CIpS
AAA+ molecular machines power myriad cellular processes including protein degradation, microtubule severing, membrane fusion, and initiation of DNA replication. Protein quality control in all organisms involves deployment of ATP-dependent proteases, consisting of hexameric AAA+ rings that unfold …
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Insights into the role and mechanism of the AAA+ adaptor Clps
Protein degradation is a vital process in cells for quality control and participation in regulatory pathways. Intracellular ATP-dependent proteases are responsible for regulated degradation and are highly controlled in their function, especially with respect to substrate selectivity. Adaptor …
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Micropropagación in vitro del clon de banano (Musa sp.) enano ecuatoriano (AAA)
Se establecieron in vitro yemas apicales de banano (Musa sp.) para su micro propagación durante tres sub-cultivos en un medio nutritivo artificial conteniendo sales minerales (MS), tiamina HCI, sacarosa y mio-inositol; variando con fines de estudio, la consistencia física del medio de cultivo …
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Untersuchungen zur Struktur und Substratspezifität des AAA+-Chaperons ClpB in Escherichia coli
… und der Substratspezifität des AAA+ Chaperons ClpB aus dem gram-negativen Modellorganismus Escherichia coli. <br>Zur Untersuchung der Struktur von ClpB wurde die Methode der limitierten Proteolyse verwendet. Daran schloß sich eine massenspektrometrischer Analyse der Fragmente an …
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Epidemiology of Banana streak virus (BSV) in East African highland bananas (AAA-EA)
The study achieved a better understanding of the epidemiology and ecology of Banana streak virus (BSV) in Uganda, generating information useful in designing management strategies to limit the spread of BSV. An identification key for the mealybugs on Musa in Africa was constructed. Screenhouse …
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Noncanonical recognition and degradation of a stable soluble protein by AAA protease FtsH
AAA+ (ATPases associated with various cellular activities) proteolytic machines help maintain and adjust the cellular proteome in response to stress or changes in nutrients. AAA+ proteases bind degradation targets and utilize ATP-powered conformational changes in the AAA+ unfoldase ring to denature …
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Nucleotide binding and conformational switching in the hexameric ring of a AAA+ machine
… and regulation in all domains of life. ClpX, a AAA+ ring homohexamer, uses the energy of ATP binding and hydrolysis to power conformational changes that unfold and translocate target proteins into the ClpP peptidase for degradation. X-ray crystal structures show that some ClpX subunits occupy …
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Comparing Hunter's ITIP With Selected Elementary Vocal Music Methods in Southwest Missouri Aaa Schools
… being used in elementary vocal music classes in AAA schools in Southwest Missouri. It also investigated the usage of other lesson designs used alone, or in combination with the Madeline Hunter design. Data was obtained from a survey instrument developed by the researcher, who analyzed the …
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Structural Principles of Substrate Recognition and Unfolding by the ClpAP and ClpXP AAA+ Proteases
… Found in all domains of life, proteases of the AAA+ (ATPases associated with diverse cellular activities) superfamily perform targeted protein degradation of specific substrates. All AAA+ proteases consist of a hexameric AAA+ unfoldase and a compartmentalized peptidase. AAA+ proteases harness …
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Chemical Biology, Biochemical and Structural Studies of MDN1, an AAA Protein Required for Ribosome Biogenesis
… time scales. Mdn1 is an essential dynein-like AAA protein (ATPases Associated with various Activities) that releases specific assembly factors from the precursors of 60S subunit of ribosomes. However, Mdn1's unusually large size (~5000 amino acids in a single polypeptide) and the transient …
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Mobility, AAA, security, privacy : a unified architecture to enable real-world host and network mobility
… Authentication, Authorization and Accounting (AAA) for mobile devices, whilst avoiding compromising their security policies. On the other hand mobile devices have privacy concerns and they may not want to reveal their identity to the Access Network they get connectivity from. Roaming Mobile …
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