Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling

Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain.

Grantor dc:publisher

Wake Forest University

Year dc:date.issued

2018

Author dc:creator

• Andrews, Rachel Nicole

• ionizing radiation

Language dc:language.iso

en

Handle dc:identifier.uri

http://hdl.handle.net/10339/90713

OAI identifier oai:identifier

oai:wakespace.lib.wfu.edu:10339/90713