{"id":{"repo_id":"wfu","oai_identifier":"oai:wakespace.lib.wfu.edu:10339/90713"},"canonical_url":"https://search.dev.ndltd.org/etd/wfu/oai:wakespace.lib.wfu.edu:10339/90713","repository":{"repo_id":"wfu","name":"Wake Forest University","base_url":"https://wakespace.lib.wfu.edu/oai/request"},"display":{"title":"Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling","abstract":"Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain.","abstract_html":"Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain.","abstract_has_math":false,"creators":["Andrews, Rachel Nicole"],"institution":"Wake Forest University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2018,"date_issued":"2018","date_published":"2018","updated_at":"2026-07-27T22:02:17Z","subjects":["ionizing radiation"],"languages":["en"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/10339/90713","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Andrews, Rachel Nicole"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-05-24T08:36:04Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2020-05-23T08:30:16Z"]},{"key":"dc:date.issued","label":"Date","values":["2018"]},{"key":"dc:publisher","label":"Institution","values":["Wake Forest University"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ionizing radiation"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/10339/90713"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain."]},{"key":"dc:title","label":"Title","values":["Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling"]}]}],"canonical_facts":{"dc:creator":["Andrews, Rachel Nicole"],"dc:date.accessioned":["2018-05-24T08:36:04Z"],"dc:date.available":["2020-05-23T08:30:16Z"],"dc:date.issued":["2018"],"dc:description.abstract":["Fractionated whole brain irradiation (fWBI), as used for the treatment of intracranial neoplasia, results in progressive cognitive impairment, and cerebrovascular and white matter injury. Although the clinical progression and morphology of late-delayed radiation-induced brain injury (RIBI) are well characterized, the pathogenesis is unclear. The long-term consequences of single high dose irradiation of the adult brain, as may occur following a nuclear accident or malicious exposure, are uncertain."],"dc:identifier.uri":["http://hdl.handle.net/10339/90713"],"dc:language.iso":["en"],"dc:publisher":["Wake Forest University"],"dc:subject":["ionizing radiation"],"dc:title":["Mechanisms of Late-Delayed Radiation-Induced Brain Injury: Insights from Extracellular Matrix and Transcriptional Profiling"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T22:02:17Z"}