A Novel Locus of Salmonella Typhimurium Involved in Survival in the Peyer's Patches

One of these Salmonella-specific genes, mil-VI , is regulated such that it is only expressed while the bacterium is in the small intestine. Virulence studies using mil-VI mutations further demonstrated that the mil-VI gene product is only required during the early stages of the infection process following oral inoculation. We have localized the function of mil-VI to survival and/or growth of Salmonella in Peyer's patches. Peyer's patches are regions of specialized lymphoid tissue involved in the uptake and processing of luminal antigens. Salmonella are capable of colonizing the Peyer's patch and can survive and multiply within the lymphoid tissue. We have renamed this locus gipA (g&barbelow;rowth i&barbelow;n P&barbelow;eyer's patches). Future analysis of this locus will lead to a better understanding of the process Salmonella uses to infect the small intestine of the host.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Microbiology

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Stanley, Theresa Luceil

Contributors dc:contributor

• Slauch, James M.

• Biology, Molecular

Language dc:language

eng

Identifier

(MiAaPQ)AAI9953146

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/86751