{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/86751"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/86751","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"A Novel Locus of Salmonella Typhimurium Involved in Survival in the Peyer's Patches","abstract":"One of these Salmonella-specific genes, mil-VI , is regulated such that it is only expressed while the bacterium is in the small intestine. Virulence studies using mil-VI mutations further demonstrated that the mil-VI gene product is only required during the early stages of the infection process following oral inoculation. We have localized the function of mil-VI to survival and/or growth of Salmonella in Peyer's patches. Peyer's patches are regions of specialized lymphoid tissue involved in the uptake and processing of luminal antigens. Salmonella are capable of colonizing the Peyer's patch and can survive and multiply within the lymphoid tissue. We have renamed this locus gipA (g&barbelow;rowth i&barbelow;n P&barbelow;eyer's patches). Future analysis of this locus will lead to a better understanding of the process Salmonella uses to infect the small intestine of the host.","abstract_html":"One of these Salmonella-specific genes, mil-VI , is regulated such that it is only expressed while the bacterium is in the small intestine. Virulence studies using mil-VI mutations further demonstrated that the mil-VI gene product is only required during the early stages of the infection process following oral inoculation. We have localized the function of mil-VI to survival and/or growth of Salmonella in Peyer's patches. Peyer's patches are regions of specialized lymphoid tissue involved in the uptake and processing of luminal antigens. Salmonella are capable of colonizing the Peyer's patch and can survive and multiply within the lymphoid tissue. We have renamed this locus gipA (g&barbelow;rowth i&barbelow;n P&barbelow;eyer's patches). Future analysis of this locus will lead to a better understanding of the process Salmonella uses to infect the small intestine of the host.","abstract_has_math":false,"creators":["Stanley, Theresa Luceil"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Microbiology","degree_department":null,"school":null,"contributors":["Slauch, James M."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-28T15:17:49Z","date_published":"2015-09-28T15:17:49Z","updated_at":"2026-07-22T22:26:27Z","subjects":["Biology, Molecular"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI9953146"],"render_values":[{"text":"(MiAaPQ)AAI9953146","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/86751","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Slauch, James M."]},{"key":"dc:creator","label":"Author","values":["Stanley, Theresa Luceil"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-28T15:17:49Z","10000-01-01","1999"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Microbiology"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Biology, Molecular"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/86751","(MiAaPQ)AAI9953146"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["One of these Salmonella-specific genes, mil-VI , is regulated such that it is only expressed while the bacterium is in the small intestine. Virulence studies using mil-VI mutations further demonstrated that the mil-VI gene product is only required during the early stages of the infection process following oral inoculation. We have localized the function of mil-VI to survival and/or growth of Salmonella in Peyer's patches. Peyer's patches are regions of specialized lymphoid tissue involved in the uptake and processing of luminal antigens. Salmonella are capable of colonizing the Peyer's patch and can survive and multiply within the lymphoid tissue. We have renamed this locus gipA (g&barbelow;rowth i&barbelow;n P&barbelow;eyer's patches). Future analysis of this locus will lead to a better understanding of the process Salmonella uses to infect the small intestine of the host.","Made available in DSpace on 2015-09-28T15:17:49Z (GMT). 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Virulence studies using mil-VI mutations further demonstrated that the mil-VI gene product is only required during the early stages of the infection process following oral inoculation. We have localized the function of mil-VI to survival and/or growth of Salmonella in Peyer's patches. Peyer's patches are regions of specialized lymphoid tissue involved in the uptake and processing of luminal antigens. Salmonella are capable of colonizing the Peyer's patch and can survive and multiply within the lymphoid tissue. We have renamed this locus gipA (g&barbelow;rowth i&barbelow;n P&barbelow;eyer's patches). Future analysis of this locus will lead to a better understanding of the process Salmonella uses to infect the small intestine of the host.","Made available in DSpace on 2015-09-28T15:17:49Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 9953146.pdf: 3510419 bytes, checksum: 167be2cf6ed7850ba0262f61bb73b354 (MD5) Previous issue date: 1999","Embargo set by: Seth Robbins for item 88032 Lift date: Forever Reason: Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","Restricted to the U of I community idenfinitely during batch ingest of legacy ETDs","U of I Only","133 p.","Thesis (Ph.D.)--University of Illinois at Urbana-Champaign, 1999."],"dc:identifier":["http://hdl.handle.net/2142/86751","(MiAaPQ)AAI9953146"],"dc:language":["eng"],"dc:subject":["Biology, Molecular"],"dc:title":["A Novel Locus of Salmonella Typhimurium Involved in Survival in the Peyer's Patches"],"dc:type":["text"],"thesis:degree_discipline":["Microbiology"],"thesis:degree_level":["Dissertation"],"thesis:degree_name":["Ph.D."],"thesis:institution_name":["University of Illinois at Urbana-Champaign"]},"updated_at":"2026-07-22T22:26:27Z"}