Metabolic Responses During Recovery From Prolonged Exercise: Role of Nutrition and Hormones

The second specific aim of this research was to investigate the regulation of insulin-like growth factor binding protein-1 production following exercise. Prolonged exercise increased plasma and hepatic levels of IGFBP-1. Neither plasma insulin and glucose levels, nor meal composition altered IGFBP-1 production following exercise. Conversely, adaptation to treadmill running markedly suppressed IGFBP-1 production, suggesting a connection between exercise stress and IGFBP-1. Further, plasma corticosterone correlated to plasma IGFBP-1 in untrained and treadmill-adapted animals following exercise. However, pre-treatment with drugs that block corticosterone synthesis and bioactivity did not prevent IGFBP-1 from rising following exercise. These results demonstrate that upregulation of IGFBP-1 following exercise is corticosteroid-independent. Further research is needed to determine the chemical factor(s) inducing IGFBP-1 production following exercise.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Nutritional Sciences

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2015

Author dc:creator

• Gautsch, Tracy Anne

Contributors dc:contributor

• Layman, Donald K.

• Health Sciences, Rehabilitation and Therapy

Language dc:language

eng

Identifier

(MiAaPQ)AAI9904462

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/84979