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University of Illinois at Urbana-Champaign
The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs
Abstract
dc:descriptionExperiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. Using fluorescent dyes sensitive to ROS it was established that dykellic acid is not capable of directly quenching ROS. Dykellic acid was also found to not directly inhibit caspase enzymes, an important family of enzymes in cellular death. While the mechanism of action of dykellic acid has yet to be elucidated, dykellic acid's potency and apparently nonstandard mechanism of action make it an interesting candidate for evaluation in models of cytoprotection.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Chemistry
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2015
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Thompson, Christina
- Contributors dc:contributor
-
- Hergenrother, Paul J.
Subjects
dc:subject × 1Rights
- Language dc:language
- eng
Identifiers
dc:identifier.*- Identifier
- (MiAaPQ)AAI3347578
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/84331