{"id":{"repo_id":"uiuc","oai_identifier":"oai:www.ideals.illinois.edu:2142/84331"},"canonical_url":"https://search.dev.ndltd.org/etd/uiuc/oai:www.ideals.illinois.edu:2142/84331","repository":{"repo_id":"uiuc","name":"University of Illinois - Urbana-Champaign","base_url":"https://www.ideals.illinois.edu/oai-pmh"},"display":{"title":"The Total Synthesis and Cytoprotective Abilities of Dykellic Acid and Its Structural Analogs","abstract":"Experiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. Using fluorescent dyes sensitive to ROS it was established that dykellic acid is not capable of directly quenching ROS. Dykellic acid was also found to not directly inhibit caspase enzymes, an important family of enzymes in cellular death. While the mechanism of action of dykellic acid has yet to be elucidated, dykellic acid's potency and apparently nonstandard mechanism of action make it an interesting candidate for evaluation in models of cytoprotection.","abstract_html":"Experiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. Using fluorescent dyes sensitive to ROS it was established that dykellic acid is not capable of directly quenching ROS. Dykellic acid was also found to not directly inhibit caspase enzymes, an important family of enzymes in cellular death. While the mechanism of action of dykellic acid has yet to be elucidated, dykellic acid's potency and apparently nonstandard mechanism of action make it an interesting candidate for evaluation in models of cytoprotection.","abstract_has_math":false,"creators":["Thompson, Christina"],"institution":"University of Illinois at Urbana-Champaign","degree_name":"Ph.D.","degree_level":"Dissertation","degree_discipline":"Chemistry","degree_department":null,"school":null,"contributors":["Hergenrother, Paul J."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-09-25T22:13:59Z","date_published":"2015-09-25T22:13:59Z","updated_at":"2026-07-22T22:26:23Z","subjects":["Chemistry, Pharmaceutical"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["(MiAaPQ)AAI3347578"],"render_values":[{"text":"(MiAaPQ)AAI3347578","href":null,"code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/2142/84331","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Hergenrother, Paul J."]},{"key":"dc:creator","label":"Author","values":["Thompson, Christina"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2015-09-25T22:13:59Z","10000-01-01","2008"]},{"key":"dc:type","label":"Dc Type","values":["text"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Chemistry"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Dissertation"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Ph.D."]},{"key":"thesis:institution_name","label":"Thesis Institution Name","values":["University of Illinois at Urbana-Champaign"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Chemistry, Pharmaceutical"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/2142/84331","(MiAaPQ)AAI3347578"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Experiments were also carried out to establish if dykellic acid's biological activity can be attributed to either of two well-established mechanisms, ROS quenching or caspase inhibition. 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