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University of Illinois at Urbana-Champaign
Monoclonal Analysis of Spontaneous and Induced Antibody Responses in Autoimmune New Zealand Mice
Abstract
dc:descriptionNew Zealand BW mice spontaneously develop lymphocytic disorders and express autoantibodies in association with an autoimmune disease similar to human SLE. A comparative monoclonal analysis of spontaneous and experimentally-induced antibody responses in autoimmune BW mice was facilitated by hybridoma technology. Various immunochemical and physicochemical parameters of generated monoclonal antibodies were examined to provide a qualitative functional and structural description of such etiologically distinct antibody repertoires in the context of inherent cellular and humoral abnormalities characteristic of this strain.
Degree
thesis:*- Name thesis:degree_name
- Ph.D.
- Level thesis:degree_level
- Dissertation
- Discipline thesis:degree_discipline
- Microbiology
- Grantor
- University of Illinois at Urbana-Champaign
- Year dc:date
- 2014
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Ballard, Dean Williams
Subjects
dc:subject × 1Identifiers
dc:identifier.*- Identifier
- (UMI)AAI8511577
- OAI identifier oai:identifier
- oai:www.ideals.illinois.edu:2142/71169