Integrating inflammatory stimuli with macromolecules for therapy and sensing of vascular diseases

Inflammation is a beneficial component for healing under normal homeostasis. However, excessive inflammation can also aggravate the patient's condition. Biochemical signals elicited under inflammatory conditions are considerably different from those under normal circumstances. Molecules such as pro-inflammatory mediator TNFα and reactive oxygen species are powerful triggers to several signaling mechanisms. In this regard, the overall goal of my research is to integrate inflammatory stimuli TNFα and ROS with macromolecules for therapy and sensing of vascular diseases. To do so, specific features of nanoparticles were studied in Chapter 2 to engineer solutions for the prevailing problems in ischemia and cancer. This thesis presents three approaches in investigating the combination of these potent inflammatory molecules with nanotechnology: (1) TNF-α-releasing liposomes were tethered on the surface of adipose-derived stem cells to enhance their secretory activities (Chapter 3). (2) Thioether-groups were incorporated into micelle-forming polymers to induce a reactive oxygen species-responsive drug release and swelling effect (Chapter 4). (3) Oxidizable chromophores were adsorbed onto support microparticles to form a hydrogen peroxide-sensing patch (Chapter 5). Overall, the results from these studies contribute to a deeper understanding of how to utilize disease biomolecules in the design of novel diagnostics and therapeutics.

Name thesis:degree_name

Ph.D.

Level thesis:degree_level

Dissertation

Discipline thesis:degree_discipline

Chemical Engineering

Grantor

University of Illinois at Urbana-Champaign

Year dc:date

2019

Author dc:creator

• Leong Jiayu, Eunice

Contributors dc:contributor

• Kong, Hyunjoon
• Yang, Yi Yan
• Schroeder, Charles
• Boppart, Marni

• Hydrogen peroxide
• nanoparticles

Statement dc:rights

• Copyright 2018 Eunice Leong Jiayu

Language dc:language

en

Handle dc:identifier

http://hdl.handle.net/2142/102878

OAI identifier oai:identifier

oai:www.ideals.illinois.edu:2142/102878